Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition

(2020) Simone F. Glaser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-specific mutation of GATA3 disrupts the transcriptional regulatory network governed by Estrogen Receptor alpha, FOXA1 and GATA3

(2020) Motoki Takaku et al.   NUCLEIC ACIDS RESEARCH

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

(2020) Nemanja Despot Marjanovic et al.   CANCER CELL

Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness

(2020) Haiquan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer

(2020) Amaia Arruabarrena-Aristorena et al.   CANCER CELL

Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding

(2019) Sofia Gkountela et al.   CELL

Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter

(2019) Yueming Zhu et al.   Nature Communications

Differential Contributions of Pre- and Post-EMT Tumor Cells in Breast Cancer Metastasis

(2019) Ana Rita Lourenco et al.   CANCER RESEARCH

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

(2019) Chenxia He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Stem Cell Phenotypes in ER+Breast Cancer Models Are Promoted by PELP1/AIB1 Complexes

(2018) Thu H. Truong et al.   MOLECULAR CANCER RESEARCH

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity

(2018) Christopher Dravis et al.   CANCER CELL

Interactome mapping defines BRG1, a component of the SWI/SNF chromatin remodeling complex, as a new partner of the transcriptional regulator CTCF

(2018) Maria Michela Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

(2018) Brittany C. Michel et al.   NATURE CELL BIOLOGY

Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance

(2018) Sara Zemanovic et al.   Cell Reports

Iron incorporation into MnSOD A (bacterial Mn-dependent superoxide dismutase) leads to the formation of a peroxidase/catalase implicated in oxidative damage to bacteria

(2015) Douglas Ganini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma

(2015) L. P. M. P. Hemachandra et al.   CANCER RESEARCH

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer

(2015) Peter C. Hart et al.   Nature Communications

Embryonic Stem Cell Specific “Master” Replication Origins at the Heart of the Loss of Pluripotency

(2015) Hanna Julienne et al.   PLoS Computational Biology

A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells

(2015) Binwu Tang et al.   Stem Cell Reports

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology

(2015) Hanna Witwicka et al.   PLoS One

Dedifferentiation and reprogramming: origins of cancer stem cells

(2014) D. Friedmann-Morvinski et al.   EMBO REPORTS

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

The peroxidase activity of mitochondrial superoxide dismutase

(2012) Kristine Ansenberger-Fricano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH