Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

A Shearing-Stretching Device That Can Apply Physiological Fluid Shear Stress and Cyclic Stretch Concurrently to Endothelial Cells

(2016) Daphne Meza et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Elastomeric free-form blood vessels for interconnecting organs on chip systems

(2016) Weijia Zhang et al.   LAB ON A CHIP

An Early-Stage Atherosclerosis Research Model Based on Microfluidics

(2016) Wenfu Zheng et al.   Small

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation

(2016) S Blondel et al.   Cell Death & Disease

Progeria, rapamycin and normal aging: recent breakthrough

(2016) Mikhail V. Blagosklonny   Aging-US

Accelerated aging syndromes, are they relevant to normal human aging?

(2016) Oliver Dreesen et al.   Aging-US

Hutchinson–Gilford progeria syndrome as a model for vascular aging

(2015) Jonathan A. Brassard et al.   BIOGERONTOLOGY

On-chip assessment of human primary cardiac fibroblasts proliferative responses to uniaxial cyclic mechanical strain

(2015) Giovanni Stefano Ugolini et al.   BIOTECHNOLOGY AND BIOENGINEERING

Vascular biology of ageing—Implications in hypertension

(2015) Adam Harvey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells

(2015) R. Sinha et al.   LAB ON A CHIP

Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei

(2015) Helal Endisha et al.   PATHOBIOLOGY

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Investigating human disease using stem cell models

(2014) Jared L. Sterneckert et al.   NATURE REVIEWS GENETICS

Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective

(2014) Pierre Cau et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

N6-isopentenyladenosine improves nuclear shape in fibroblasts from humans with progeroid syndromes by inhibiting the farnesylation of prelamin A

(2013) Maurizio Bifulco et al.   FEBS Journal

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

A novel system for studying mechanical strain waveform-dependent responses in vascular smooth muscle cells

(2013) Jason Lee et al.   LAB ON A CHIP

Cyclic Tensile Strain Controls Cell Shape and Directs Actin Stress Fiber Formation and Focal Adhesion Alignment in Spreading Cells

(2013) Alexandra M. Greiner et al.   PLoS One

Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions

(2013) Yue Shao et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Precise determination of the Poisson ratio in soft materials with 2D digital image correlation

(2013) Robyn H. Pritchard et al.   Soft Matter

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension

(2012) Eric D. Austin et al.   Circulation-Cardiovascular Genetics

Nuclear lamina defects cause ATM-dependent NF- B activation and link accelerated aging to a systemic inflammatory response

(2012) F. G. Osorio et al.   GENES & DEVELOPMENT

Microfluidic artificial “vessels” for dynamic mechanical stimulation of mesenchymal stem cells

(2012) Jing Zhou et al.   Integrative Biology

The Effect of Pressure-Induced Mechanical Stretch on Vascular Wall Differential Gene Expression

(2012) M.A. Anwar et al.   JOURNAL OF VASCULAR RESEARCH

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

(2012) L. B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

(2012) Xavier Nissan et al.   Cell Reports

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of shear stress and stretch in vascular mechanobiology

(2011) D. Lu et al.   Journal of the Royal Society Interface

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

The Farnesyltransferase Inhibitors Tipifarnib and Lonafarnib Inhibit Cytokines Secretion in a Cellular Model of Mevalonate Kinase Deficiency

(2011) Annalisa Marcuzzi et al.   PEDIATRIC RESEARCH

Towards the Maturation and Characterization of Smooth Muscle Cells Derived from Human Embryonic Stem Cells

(2011) Helena Vazão et al.   PLoS One

Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

(2010) Michelle Olive et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Reactive Oxygen Species, NADPH Oxidases, and Hypertension

(2010) Srinivasa Raju Datla et al.   HYPERTENSION

Inflammation, Immunity, and Hypertension

(2010) David G. Harrison et al.   HYPERTENSION

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors

(2008) Valerie L. R. M. Verstraeten et al.   AGING CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

NADPH Oxidases, Reactive Oxygen Species, and Hypertension: Clinical implications and therapeutic possibilities

(2008) T. M. Paravicini et al.   DIABETES CARE

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Phenotype and Course of Hutchinson–Gilford Progeria Syndrome

(2008) Melissa A. Merideth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Cyclic Strain Frequency in Regulating the Alignment of Vascular Smooth Muscle Cells In Vitro

(2007) Bo Liu et al.   BIOPHYSICAL JOURNAL