期刊
SMALL
卷 12, 期 15, 页码 2022-2034出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201503241
关键词
atherosclerosis; microfluidic chips; drug screening; mechanics; blood vessels
类别
资金
- Ministry of Science and Technology of China [2011CB933201]
- National Science Foundation of China [31170905, 81361140345, 31470911, 51373043]
- Chinese Academy of Sciences [XDA09030305, XDA09030307]
- CAS/SAFEA International Partnership Program for Creative Research Teams
The arterial microenvironment plays a vital role in the pathology of atherosclerosis (AS). However, the interplay between the arterial microenvironment and atherogenesis remains unclear, partially due to the gap between cell culture and animal experiments. Addressing this problem, the present study reports a microfluidic AS model reconstituting early-stage AS. Physiological or AS-prone hemodynamic conditions are recapitulated on the model. The on-chip model recaptures the atherogenic responses of endothelial cells (ECs) in ways that the Petri dish could not. Significant cytotoxicity of a clinical anti-atherosclerotic drug probucol is discovered on the model, which does not appear on Petri dish but is supported by previous clinical evidence. Moreover, the anti-AS efficiency of platinum-nanoparticles (Pt-NPs) on the model shows excellent consistency with animal experiments. The early-stage AS model shows an excellent connection between Petri dish and animal experiments and highlights its promising role in bridging fundamental AS research, drug screening, and clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据