Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

Dihydromyricetin protects against cerebral ischemia/reperfusion injury via suppressing microglia-mediated neuroinflammation and activation of ERK1/2-CREB signaling pathway

(2017) Yafei Zhao et al.   Journal of Functional Foods

Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

(2016) Zhao-xiang Ren et al.   ACTA PHARMACOLOGICA SINICA

The cardioprotective effect of dihydromyricetin prevents ischemia–reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways

(2016) Shasha Liu et al.   APOPTOSIS

Liquiritigenin reverses depression-like behavior in unpredictable chronic mild stress-induced mice by regulating PI3K/Akt/mTOR mediated BDNF/TrkB pathway

(2016) Weiwei Tao et al.   BEHAVIOURAL BRAIN RESEARCH

A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice

(2016) Ana Paula Pesarico et al.   BEHAVIOURAL BRAIN RESEARCH

Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

(2016) Naoko Abe-Higuchi et al.   BIOLOGICAL PSYCHIATRY

Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity

(2016) Yun Wang et al.   CNS Neuroscience & Therapeutics

Suppression of reactive oxygen species-mediated ERK and JNK activation sensitizes dihydromyricetin-induced mitochondrial apoptosis in human non-small cell lung cancer

(2016) Shang-Jyh Kao et al.   ENVIRONMENTAL TOXICOLOGY

Lipopolysaccharide-Induced Behavioral Alterations Are Alleviated by Sodium Phenylbutyrate via Attenuation of Oxidative Stress and Neuroinflammatory Cascade

(2016) Ashok Jangra et al.   INFLAMMATION

BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects ofMorinda officinalisOligosaccharides in Rats

(2016) Ling-Zhi Xu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Stress-Related Immune Markers in Depression: Implications for Treatment

(2016) Martina M. Hughes et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dihydromyricetin suppresses TNF-α-induced NF-κB activation and target gene expression

(2016) Nina Tang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Lipopolysaccharide induced anxiety- and depressive-like behaviour in mice are prevented by chronic pre-treatment of esculetin

(2016) Kunjbihari Sulakhiya et al.   NEUROSCIENCE LETTERS

Antidepressant-like effects of sodium butyrate and its possible mechanisms of action in mice exposed to chronic unpredictable mild stress

(2016) Jing Sun et al.   NEUROSCIENCE LETTERS

Modulatory Effects of Antidepressant Classes on the Innate and Adaptive Immune System in Depression

(2016) H. Eyre et al.   PHARMACOPSYCHIATRY

Esculetin attenuates lipopolysaccharide (LPS)-induced neuroinflammatory processes and depressive-like behavior in mice

(2016) Lingpeng Zhu et al.   PHYSIOLOGY & BEHAVIOR

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

(2016) Bangkun Yang et al.   PSYCHOPHARMACOLOGY

Brain-derived neurotrophic factor increase during treatment in severe mental illness inpatients

(2016) G L Nuernberg et al.   Translational Psychiatry

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

(2016) Eric S. Wohleb   Frontiers in Immunology

MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

(2015) Jingshu Ni et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function

(2015) Elena Dale et al.   CNS SPECTRUMS

Suppression of Inflammatory Responses by Dihydromyricetin, a Flavonoid from Ampelopsis grossedentata, via Inhibiting the Activation of NF-κB and MAPK Signaling Pathways

(2015) X. L. Hou et al.   JOURNAL OF NATURAL PRODUCTS

Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

(2015) Zhuang Wu et al.   JOURNAL OF NEUROCHEMISTRY

Determination of dihydromyricetin in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

(2015) Qing Tong et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study

(2015) M H Rapaport et al.   MOLECULAR PSYCHIATRY

BDNF Val66Met polymorphism and hippocampal volume in neuropsychiatric disorders: A systematic review and meta-analysis

(2015) F. Harrisberger et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   PHARMACOLOGICAL RESEARCH

Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation

(2015) Luana M. Manosso et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice

(2015) Natsuki Kurosawa et al.   PSYCHOPHARMACOLOGY

Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injuryviaJNK-dependent mechanism in mice

(2015) Jun Xie   WORLD JOURNAL OF GASTROENTEROLOGY

Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells

(2014) Baoping Jiang et al.   BRAIN RESEARCH BULLETIN

Dihydromyricetin Ameliorates Behavioral Deficits and Reverses Neuropathology of Transgenic Mouse Models of Alzheimer’s Disease

(2014) Jing Liang et al.   NEUROCHEMICAL RESEARCH

Inflammatory and Metabolic Dysregulation and the 2-Year Course of Depressive Disorders in Antidepressant Users

(2014) Nicole Vogelzangs et al.   NEUROPSYCHOPHARMACOLOGY

SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity

(2013) Xing Fang et al.   ACTA PHARMACOLOGICA SINICA

Involvement of Brain-Derived Neurotrophic Factor in Late-Life Depression

(2013) Yogesh Dwivedi   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Ketamine: synaptogenesis, immunomodulation and glycogen synthase kinase-3 as underlying mechanisms of its antidepressant properties

(2013) P A Zunszain et al.   MOLECULAR PSYCHIATRY

Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication

(2012) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Chronic inhibition of glycogen synthase kinase-3 protects against rotenone-induced cell death in human neuron-like cells by increasing BDNF secretion

(2012) Alfredo Giménez-Cassina et al.   NEUROSCIENCE LETTERS

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

(2011) Sook-Eun Park et al.   Journal of Neuroinflammation

Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

(2010) Naoto Omata et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase-3 regulates inflammatory tolerance in astrocytes

(2010) E. Beurel et al.   NEUROSCIENCE

LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-γ-independent manner by a JNK signaling pathway in primary murine microglia

(2009) Yunxia Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Glycogen synthase kinase-3β gene is associated with antidepressant treatment response in Chinese major depressive disorder

(2008) S-J Tsai et al.   PHARMACOGENOMICS JOURNAL