Article
Clinical Neurology
Wei Shi, Shan Zhang, Yujia Lu, Yaning Wang, Jingjie Zhao, Li Li
Summary: The study using a mouse model found that exposure to chronic unpredictable mild stress (CUMS) can induce depression-like behaviors and decrease Th17 cell counts.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Nutrition & Dietetics
Chorpeth Chalermwongkul, Charinya Khamphukdee, Juthamart Maneenet, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit
Summary: Major depressive disorder (MDD) is a prevalent worldwide disease with unclear etiology. Herbal medicine is gaining interest as an alternative antidepressant, and Oroxylum indicum extract containing baicalin and baicalein shows potential as an effective treatment for MDD by normalizing the HPA axis function and improving neurogenesis.
Article
Pharmacology & Pharmacy
Mahdieh Salari, Fatemeh Zare Mehrjerdi, Maryam Yadegari, Mohammad Ebrahim Rezvani, Azadeh Shahrokhi Raeini
Summary: Recent studies have shown that sulfur dioxide (SO2) has a protective effect on ischemic heart disease, atherosclerosis, and lung infections. This study aimed to investigate the effect of endogenous SO2 on depression. The results showed that depressed animals treated with SO2 demonstrated improvement in behavioral and cognitive functions, as well as reduced neuronal damage and oxidative stress.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Psychiatry
Ning Jiang, Haixia Wang, Hong Huang, Jingwei Lv, Guirong Zeng, Qiong Wang, Yu Bao, Ying Chen, Xinmin Liu
Summary: Medicinal plant species in Shen yuan prescription demonstrate potent antidepressant-like effects, reversing depressive-like behaviors in rats by regulating neurotransmitter levels, suppressing neuroinflammation, and activating BDNF/TrkB pathway, among other mechanisms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Stifani Machado Araujo, Vandreza Cardoso Bortolotto, Marcia Rosula Poetini, Mustafa Munir Mustafa Dahleh, Shanda de Freitas Couto, Franciane Cabral Pinheiro, Luana Barreto Meichtry, Elize Aparecida Santos Musachio, Bruna Piaia Ramborger, Rafael Roehrs, Gustavo Petri Guerra, Marina Prigol
Summary: The experiment demonstrated that gamma-oryzanol (ORY) showed antidepressant effects in a Chronic Unpredictable Mild Stress (CUMS)-induced depressive model in male Drosophila melanogaster. ORY prevented reduction in serotonin (5HT) and octopamine (OCT) levels and partially protected dopamine (DA) reduction, indicating its potential as an antidepressant compound.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Chemistry, Medicinal
Meng Qin, Chen Chen, Ning Wang, Di Yu, Shangmin Yu, Xinying Wang, Tongyan Liu, Linlin Lv, Qingxiang Guan
Summary: Total saponins of Panax ginseng (TSPG) have antidepressant effects, but the underlying mechanism is unclear. This study used bioinformatics analysis to predict the mechanism of TSPG and experimentally verified it. The results suggest that the antidepressant effect of TSPG may be achieved through inhibition of CX3CL1/CX3CR1.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Maria Salud Garcia-Gutierrez, Daniela Navarro, Amaya Austrich-Olivares, Jorge Manzanares
Summary: This study aims to characterize the pharmacological and molecular profile of cannabidiol (CBD) as an antidepressant. The effects of CBD, alone or combined with sertraline (STR), were evaluated in mice exposed to chronic stress. CBD showed faster and more significant antidepressant-like effects compared to STR, but the combination of CBD and STR had a negative impact on treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Behavioral Sciences
Y. V. M. Lages, A. D. Rossi, T. E. Krahe, J. Landeira-Fernandez
Summary: This study investigated the changes of 5-HT receptors in animal models of chronic-stress-induced depression, finding altered expression of 5-HT1A receptors in the frontal cortex and changes in 5-HT2A receptors in the whole cortex and hypothalamus of rats following CUMS. By including a qualitative-structured analysis and risk-of-bias tools, potential sources of data variation between studies were identified, emphasizing the importance of considering these in future research on chronic-stress induced depression in animals.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Xiao-Ling Li, Hua Liu, Shu-Han Liu, Yong Cheng, Guo-Jun Xie
Summary: This study demonstrates that intranasal administration of BDNF can reduce depressive-like behaviors induced by chronic unpredictable mild stress, decrease the expression of inflammatory cytokines, and attenuate oxidative stress. Additionally, BDNF treatment increases neurogenesis in the hippocampus. These findings suggest that BDNF may represent a new therapeutic strategy for major depressive disorder.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Psychiatry
Lanwei Hou, Jingyu Miao, Haiwei Meng, Xiao Liu, Di Wang, Yawen Tan, Chuangang Li
Summary: This study found that S-ketamine can alleviate depression-like behavior by upregulating SIRT1-mediated BDNF in the medial prefrontal cortex (mPFC).
FRONTIERS IN PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Jingxuan Tan, Xixuan Li, Ying Zhu, Mitchell A. Sullivan, Bin Deng, Xuejia Zhai, Yongning Lu
Summary: This study investigated the effects of therapy with Shugan Jieyu Capsule (SG) on gut microbiota and intestinal microbiome function in rats with chronic unpredictable mild stress (CUMS)-induced depression. The results showed that SG could reverse depression-like behaviors, decrease corticosterone levels and adrenal index, increase serotonin levels, and improve the richness and uniformity of the microbiota. SG also regulated the relative abundance of certain bacteria and modulated metabolic pathways. These findings contribute to our understanding of the therapeutic function of traditional Chinese antidepressants.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Denis A. Borozdenko, Darya I. Gonchar, Vlada I. Bogorodova, Dmitri V. Tarasenko, Evgeniya P. Kramarova, Svetlana S. Khovanova, Yaroslav V. Golubev, Nina M. Kiseleva, Tatiana A. Shmigol, Aiarpi A. Ezdoglian, Konstantin A. Sobyanin, Vadim V. Negrebetsky, Yuri I. Baukov
Summary: This study demonstrates that Compound I has reliable antidepressant activity, comparable to the reference antidepressant Fluoxetine, suggesting its therapeutic potential in depression treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ruhan Deniz Topuz, Mehmet Zahid Cetinkaya, Dilsat Erumit, Kubra Duvan Aydemir, Ozgur Gunduz, Cetin Hakan Karadag, Ahmet Ulugol
Summary: Dipyrone exhibited antidepressant and anxiolytic effects in mice exposed to chronic unpredictable mild stress, with its anxiolytic effect possibly mediated through CB1 receptors and its antidepressant action possibly mediated through TRPV1 receptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Vivian B. Neis, Isabel Werle, Morgana Moretti, Priscila B. Rosa, Anderson Camargo, Yasmim de O. Dalsenter, Nicolle Platt, Axel F. Rosado, William D. Engel, Gudrian Ricardo L. de Almeida, Ingrid Selhorst, Alcir Luiz Dafre, Ana Lucia S. Rodrigues
Summary: Cholecalciferol deficiency has been associated with stress-related psychiatric disorders, particularly depression. However, this study found that cholecalciferol has an antidepressant-like effect in female mice and may exert its effects through modulation of the serotonergic system.
METABOLIC BRAIN DISEASE
(2022)
Article
Integrative & Complementary Medicine
Chen-Yue Liu, Jian-Bei Chen, Yue-Yun Liu, Xue-Ming Zhou, Man Zhang, You-Ming Jiang, Qing-Yu Ma, Zhe Xue, Zong-Yao Zhao, Xiao-Juan Li, Jia-Xu Chen
Summary: This study suggests that SSD treatment reduces glutamate levels in the hippocampal CA1 region and promotes the expression of synaptic proteins PSD-95 and SYP through the regulation of the Homer1-mGluR5 and downstream mTOR signaling pathways.
Article
Biochemistry & Molecular Biology
Renata F. Rodrigues, Bruna C. W. Fulco, Cristina W. Nogueira
Summary: The study found that (mCF3-PhSe)(2) attenuated morphine-induced locomotor sensitization by modulating weight gain, locomotor activity, and protein contents of opioid and glutamate receptors in the cerebral cortex. The compound did not affect dopaminergic receptors in the acquisition phase, but was effective against behavioral and molecular alterations caused by morphine at all phases of locomotor sensitization.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carolina C. Martins, Suzan G. Rosa, Vanessa A. Zborowski, Renata F. Rodrigues, Adriano Maroneze, Cristina W. Nogueira, Gilson Zeni
Summary: This study found that m-trifluoromethyl diphenyl diselenide (TFDD) can alleviate the tolerance development to the analgesic and antidepressant effects of morphine in mice, and restore the effects of morphine on opioid receptors and nitrergic system.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Paloma T. Birmann, Angela M. Casaril, Giuliana P. Zugno, Gabriela G. Acosta, Fernanda Severo Sabedra Sousa, Tiago Collares, Fabiana K. Seixas, Raquel G. Jacob, Cesar A. Bruning, Lucielli Savegnago, Daniela Hartwig
Summary: This study demonstrated the potential therapeutic effects of flower essential oil from Tagetes minuta in attenuating depressive-like behavior induced by stress or inflammation. The oil reversed oxidative stress, decreased corticosterone levels, and restored the expression of neurotrophic factors, suggesting its promising antidepressant properties.
Article
Biochemistry & Molecular Biology
Kauane Nayara Bahr Ledebuhr, Gustavo D. 'Avila Nunes, Evelyn Mianes Besckow, Maira Regina Giehl, Benhur Godoi, Cristiani Folharini Bortolatto, Cesar Augusto Bruning
Summary: This study evaluated the antinociceptive effect of the compound SePB and found that it demonstrated analgesic properties without affecting the locomotor activity of the mice. The antinociceptive effect of SePB was shown to involve the serotonin receptors. Further research is needed to assess its efficacy and toxicity in chronic pain models.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Paloma T. Birmann, Angela M. Casaril, Laura Abenante, Filipe Penteado, Cesar A. Bruning, Lucielli Savegnago, Eder J. Lenardao
Summary: This review summarizes recent preclinical studies on organoselenium compounds as therapeutic agents for the treatment of mental and neurodegenerative diseases. Diaryl diselenides, Ebselen-derivatives, and Se-containing heterocycles are identified as the most representative organoselenium molecules. The review aims to provide disease-oriented information that can be useful for the development of novel bioactive molecules with potential clinical viability.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Juliano Ten Kathen Jung, Luiza Souza Marques, Vanessa Angonesi Zborowski, Guilherme Lutz Silva, Cristina Wayne Nogueira, Gilson Zeni
Summary: This study evaluated the role of resistance exercise in an anxiety-depression-like dyad in a model of stress. The results showed that resistance exercise can alleviate anxiety and depressive symptoms in stressed mice, while reducing neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luiza Spohr, Mayara Sandrielly Soares de Aguiar, Natalia Pontes Bona, Karina Pereira Luduvico, Amalia Goncalves Alves, William Borges Domingues, Eduardo Bierhals Blodorn, Cristiani Folharini Bortolatto, Cesar Augusto Bruning, Vinicius Farias Campos, Francieli Moro Stefanello, Roselia Maria Spanevello
Summary: This study found that blueberry extract improved depression-like behavior and attenuated neurochemical and molecular changes in the brains of mice challenged with LPS.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Marcia Juciele da Rocha, Camila Simoes Pires, Marcelo Heinemann Presa, Evelyn Mianes Besckow, Gustavo D'Avila Nunes, Caroline Signorini Gomes, Filipe Penteado, Eder Joao Lenardao, Cristiani Folharini Bortolatto, Cesar Augusto Bruning
Summary: The compound MeSeI has shown antidepressant-like effects and may be considered as a potential treatment for depression.
PSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcelo Heinemann Presa, Marcia Juciele da Rocha, Camila Simoes Pires, Kauane Nayara Bahr Ledebuhr, Gabriel Pereira da Costa, Diego Alves, Cristiani Folharini Bortolatto, Ceisar Augusto Bruning
Summary: This study evaluated the antidepressant-like effect of a hybrid compound containing triazole and acetophenone, demonstrating that it modulates the serotonergic system through 5-HT2A/2C and 5-HT4 receptors and inhibits monoamine oxidase A activity in the hippocampus. The compound showed penetration into the central nervous system and low toxicity at a high dose, making it an interesting candidate for the development of a new therapeutic strategy for major depressive disorder (MDD).
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tais da Silva Teixeira Rech, Estela Hartwig Ribeiro, Ediandra Tissot Castro, Amalia Goncalves Alves, Dianer Nornberg Strelow, Jose Sebastiao Santos Neto, Antonio Luiz Braga, Cesar Agusto Bruning, Cristiani Folharini Bortolatto
Summary: The study found that the functionalized 3-selanyl benzo[b]furan (SeBZF) has antidepressant-like potential in mice. Specifically, SeBZF3 exhibited antidepressant-like effects and interacted with 5-HT1A, 5-HT2A/C, and 5-HT3 receptors. Furthermore, SeBZF3 showed synergistic action with the selective serotonin reuptake inhibitor fluoxetine and did not induce acute oral toxicity at high doses.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sabrina G. Muller, Natalia S. Jardim, Guilherme Lutz, Gilson Zeni, Cristina W. Nogueira
Summary: This study investigated the anxiolytic-like effect of (m-CF3-PhSe)2 and its modulation of synaptic plasticity and NMDAR-mediated neurotoxicity in young mice exposed to a lifestyle model. The results showed that (m-CF3-PhSe)2 abolished anxiety-like behavior, reversed neurotoxicity, and restored synaptic plasticity-related signaling. These findings suggest that (m-CF3-PhSe)2 may be a potential candidate for anxiolytic drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Sabrina G. Mueller, Natalia S. Jardim, Gilson Zeni, Cristina W. Nogueira
Summary: In this study, the efficacy of (m-CF3-PhSe)2 against lifestyle model-related metabolic disturbances and hypothalamic inflammation in young mice was investigated. The results showed that (m-CF3-PhSe)2 reduced relative adipose tissue weight, hyperglycemia, and dyslipidemia in mice exposed to the lifestyle-induced model. It also modulated various metabolic and inflammatory markers in the liver and hypothalamus of the mice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Infectious Diseases
Livia Silveira Munhoz, Vanice Rodrigues Poester, Jessica Louise Benelli, Aryse Martins Melo, Mariana Rodrigues Trapaga, Cristina Wayne Nogueira, Gilson Zeni, Mariana Martins Flores, David A. Stevens, Melissa Orzechowski Xavier
Summary: This study demonstrates the potential use of diphenyl diselenide (PhSe)(2) in the treatment of sporotrichosis caused by S. brasiliensis. PhSe(2) showed antifungal activity against Sporothrix brasiliensis and when used in combination with itraconazole, it enhanced the treatment effect.
Article
Psychology, Biological
Luiza S. Marques, Juliano TK. Jung, Vanessa A. Zborowski, Roberto C. Pinheiro, Cristina W. Nogueira, Gilson Zeni
Summary: Excessive stress can lead to depression and anxiety, affecting gastrointestinal functionality and microbiota changes. The study found that Emotional-Single Prolonged Stress (E-SPS) induced depressive/anxiety-like phenotype and gut dysfunction in adult male mice.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
