Article
Immunology
Alzahra J. Al Omran, Amy S. Shao, Saki Watanabe, Zeyu Zhang, Jifeng Zhang, Chen Xue, Junji Watanabe, Daryl L. Davies, Xuesi M. Shao, Jing Liang
Summary: This study found that social isolation contributes to increased anxiety levels and neuroinflammation, while dihydromyricetin (DHM) has the ability to improve these effects.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Shanu George, John Bear, Michael J. Taylor, Karthik Kanamalla, Christopher D. Fekete, Tzu-Ting Chiou, Celia P. Miralles, Theofilos Papadopoulos, Angel L. De Blas
Summary: Collybistin (CB) is a guanine nucleotide exchange factor selectively localized at GABAergic and glycinergic postsynapses. Different isoforms of collybistin are expressed in the brain, with CBSH3- protein playing a significant role in the regulation of the size of GABAergic postsynapse clusters, particularly in parvalbumin positive interneurons. The lack of CBSH3- expression is an important issue because it has a strong effect in promoting the postsynaptic clustering of gephyrin and GABA-A receptors.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Shanu George, Tzu-Ting Chiou, Karthik Kanamalla, Angel L. De Blas
Summary: The subunit composition of GABA(A) receptors plays a key role in determining their synaptic or extrasynaptic localization. The Geph/CB lattice can trap both synaptic and extrasynaptic GABA(A) receptors, but does not play a decisive role in their synaptic localization. Neurons likely have mechanisms to prevent the trapping of certain extrasynaptic GABA(A) receptors by the postsynaptic Geph/CB lattice.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Teresa M. L. Cramer, Berangere Pinan-Lucarre, Anna Cavaccini, Angeliki Damilou, Yuan-Chen Tsai, Musadiq A. Bhat, Patrizia Panzanelli, Nicolas Rama, Patrick Mehlen, Dietmar Benke, Theofanis Karayannis, Jean-Louis Bessereau, Shiva K. Tyagarajan
Summary: The study reveals the crucial role of Adamtsl3 and DCC in synapse formation and maintenance, particularly in the adaptation of GABAergic synapses. These findings are of significant importance for schizophrenia research.
Correction
Cell Biology
Shanu George, Tzu-Ting Chiou, Karthik Kanamalla, Angel L. De Blas
Summary: There were editorial errors in the supplementary material of the original version of this article.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz, Andrew S. Murtishaw, Jefferson W. Kinney
Summary: The study demonstrates altered GABAergic signaling in an amyloid model of AD, with changes in GABA-related targets associated with disease-related memory and learning deficits.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Linda Patt, Dario Tascio, Catia Domingos, Aline Timmermann, Ronald Jabs, Christian Henneberger, Christian Steinhaeuser, Gerald Seifert
Summary: NG2 glia receive synaptic input from neurons, but the functional impact of this glial innervation is not well understood. In the developing cerebellum and somatosensory cortex the GABAergic input might regulate NG2 glia differentiation and myelination, and a switch from synaptic to extrasynaptic neuron-glia signaling was reported in the latter region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yaxin Yang, Jian Liu, Yixuan Wang, Xiang Wu, Libo Li, Guanyun Bian, Wenjuan Li, Haifeng Yuan, Qiaojun Zhang
Summary: This study found that unilateral lesions of the substantia nigra pars compacta in rats lead to anxiety-like behaviors and hyperactivity of lateral habenula neurons. Both pre-synaptic and post-synaptic GABA(B) receptors in the lateral habenula regulate anxiety-like behaviors.
Article
Clinical Neurology
Yang Li, Ke Zhu, Ning Li, Xiaotong Wang, Xuansheng Xiao, Linying Li, Lijuan Li, Ying He, Jinglan Zhang, Jiaoyang Wo, Yanqiu Cui, Haixia Huang, Jianliang Zhang, Wei Wang, Xiaomin Wang, Yan Zheng
Summary: The study found that 5XFAD mice exhibited hyperactivity in hippocampal CA1 pyramidal neurons, reduced inhibitory postsynaptic currents, and decreased density of GABA(A) receptor subunits. Early intervention with a GABA(A) receptor agonist was able to reverse the hyperactivity in mice and modestly improve cognitive performance.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Saki Watanabe, Alzahra Al Omran, Amy S. Shao, Chen Xue, Zeyu Zhang, Jifeng Zhang, Daryl L. Davies, Xuesi M. Shao, Junji Watanabe, Jing Liang
Summary: Social isolation leads to cognitive decline and anxiety, which may involve the dysfunction and morphological changes of astrocytes. Dihydromyricetin improves memory/cognition and restores astrocyte plasticity.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Parviz Naderipoor, Mohammad Amani, Ali Abedi, Nona Sakhaie, Farshid Sadegzadeh, Hakimeh Saadati
Summary: The study found that blockade of GABA-A receptors in neonatal rats can affect neurobehavioral phenotypes in adulthood, with higher doses increasing passive avoidance memory and hippocampal BDNF levels, while lower doses impair this memory type and increase PFC BDNF levels. Additionally, drug treatment during the neonatal period increased anxiety and pain sensitivity in a dose-dependent manner. Overall, these results suggest the importance of GABA-A receptors in programming neurobehavioral phenotypes in adult life.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Eileen Carry, Dushyant Kshatriya, Joshua Silva, Daryl L. Davies, Bo Yuan, Qingli Wu, Harna Patel, Elizabeth R. Park, John Gilleran, Lihong Hao, Jacques Roberge, Nicholas T. Bello, James E. Simon
Summary: Dihydromyricetin is a flavonoid with unique GABA(A) receptor activity that can reduce the intoxication effects of ethanol. Experimental results indicate that the administration route and sex significantly impact the bioavailability of dihydromyricetin, limiting its long-term anti-intoxicating effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Cui-Cui Sun, Zhong-Ping Yin, Ji-Guang Chen, Wen-Jun Wang, Guo-Dong Zheng, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang
Summary: The study found that dihydromyricetin can improve cognitive impairment in d-galactose-induced aging mice by regulating oxidative stress and inhibiting acetylcholinesterase.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Neurosciences
Shanu George, Shaun James, Angel L. De Blas
Summary: Collybistin (CB) interacts with gephyrin at inhibitory synapses and enhances accumulation of GABA receptors. CBSH3- can strengthen GABAergic synapses and provide protection against seizures.
Review
Cell Biology
Bradley M. Roberts, Emanuel F. Lopes, Stephanie J. Cragg
Summary: Striatal dopamine release is inhibited by striatal gamma-aminobutyric acid (GABA) acting via GABA(A) and GABA(B) receptors, which is regulated by plasma membrane GABA uptake transporters on striatal astrocytes. The regulation of striatal GABA-DA interactions serves as a potential therapeutic target for psychomotor disorders associated with dysregulated DA signaling.
Article
Neurosciences
Stephen T. Yeung, Hilda Martinez-Coria, Rahasson R. Ager, Carlos J. Rodriguez-Ortiz, David Baglietto-Vargas, Frank M. LaFerla
BRAIN RESEARCH BULLETIN
(2015)
Article
Multidisciplinary Sciences
Xuesi M. Shao, Hector E. Lopez-Valdes, Jing Liang, Jack L. Feldman
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Carlos J. Rodriguez-Ortiz, David Baglietto-Vargas, Hilda Martinez-Coria, Frank M. LaFerla, Masashi Kitazawa
JOURNAL OF ALZHEIMERS DISEASE
(2014)
Article
Neurosciences
Yujie T. Tang, Jorge M. Mendez, Jeremy J. Theriot, Punam M. Sawant, Hector E. Lopez-Valdes, Y. Sungtaek Ju, K. C. Brennan
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Medicine, Research & Experimental
E. Orta-Salazar, A. Aguilar-Vazquez, H. Martinez-Coria, S. Luquin-De Anda, M. Rivera-Cervantes, C. Beas-Zarate, A. Feria-Velasco, S. Diaz-Cintra
Correction
Biochemistry & Molecular Biology
Jing Liang, Hector E. Lopez-Valdes, Hilda Martínez-Coria, A. Kerstin Lindemeyer, Yi Shen, Xuesi M. Shao, Richard W. Olsen
NEUROCHEMICAL RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Jorge Ivan Castillo-Arellano, Juan Carlos Gomez-Verjan, Nadia A. Rojano-Vilchis, Myrna Mendoza-Cruz, Manuel Jimenez-Estrada, Hector E. Lopez-Valdes, Hilda Martinez-Coria, Roger Gutierrez-Juarez, Claudia Gonzalez-Espinosa, Ricardo Reyes-Chilpa, Isabel Arrieta-Cruz
Review
Pharmacology & Pharmacy
Hilda Martinez-Coria, Martha X. Mendoza-Rojas, Isabel Arrieta-Cruz, Hector E. Lopez-Valdes
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Cell Biology
Esteban Olvera-Juarez, Carlos-Camilo Silva, Angelica Flores, Isabel Arrieta-Cruz, Luciano Mendoza-Garces, Hilda Martinez-Coria, Hector E. Lopez-Valdes, Mario Cardenas, Roberto Dominguez, Roger Gutierrez-Juarez, Maria-Esther Cruz
CELL AND TISSUE RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Isabel Arrieta-Cruz, Blanca Samara Torres-Avila, Hilda Martinez-Coria, Hector Eduardo Lopez-Valdes, Roger Gutierrez-Juarez
Summary: A sedentary lifestyle and high-fat diets contribute to the rapid growth of type 2 diabetes mellitus. The mediobasal hypothalamus plays a crucial role in detecting nutritional cues and regulating glucose production. Negative environmental factors can impair these adaptive responses and contribute to the development of metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Hilda Martinez-Coria, Isabel Arrieta-Cruz, Maria-Esther Cruz, Hector Lopez-Valdes
Summary: Ischemic stroke is the most common type of cerebrovascular disease, with treatments like recombinant tissue plasminogen activator and endovascular thrombectomy having limited efficacy. Memantine, already approved for Alzheimer's disease, shows potential in improving functional recovery for stroke patients, but further clinical trials are needed for validation.
NEURAL REGENERATION RESEARCH
(2021)
Article
Medicine, General & Internal
Hector E. Lopez-Valdes, Hilda Martinez-Coria
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2016)