Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition

SkfB Abstracts a Hydrogen Atom from Cα on SkfA To Initiate Thioether Cross-Link Formation

(2016) Nathan A. Bruender et al.   BIOCHEMISTRY

Demonstration That the RadicalS-Adenosylmethionine (SAM) Enzyme PqqE Catalyzesde NovoCarbon-Carbon Cross-linking within a Peptide Substrate PqqA in the Presence of the Peptide Chaperone PqqD

(2016) Ian Barr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

(2016) Kunhua Li et al.   Nature Chemical Biology

Carbon–sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE

(2016) Roman Rohac et al.   Nature Chemistry

Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

(2016) E. L. Schwalm et al.   SCIENCE

PqqD Is a Novel Peptide Chaperone That Forms a Ternary Complex with the RadicalS-Adenosylmethionine Protein PqqE in the Pyrroloquinoline Quinone Biosynthetic Pathway

(2015) John A. Latham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

(2015) Jesko Koehnke et al.   Nature Chemical Biology

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

(2015) Brandon J Burkhart et al.   Nature Chemical Biology

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

(2015) Kelsey R. Schramma et al.   Nature Chemistry

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

SPASM and Twitch Domains inS-Adenosylmethionine (SAM) Radical Enzymes

(2014) Tsehai A. J. Grell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

(2013) P. J. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

(2013) P. J. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural diversity in the AdoMet radical enzyme superfamily

(2012) Daniel P. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Emerging themes in radical SAM chemistry

(2012) Krista A Shisler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners

(2011) Daniel H Haft   BMC GENOMICS

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci

(2011) B. Fleuchot et al.   MOLECULAR MICROBIOLOGY

Guidelines for tunneling in enzymes

(2010) Christopher C. Moser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

(2010) Stephen R. Wecksler et al.   CHEMICAL COMMUNICATIONS

How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic

(2009) Catherine A Regni et al.   EMBO JOURNAL

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Xanthomonas campestrisPqqD in the pyrroloquinoline quinone biosynthesis operon adopts a novel saddle-like fold that possibly serves as a PQQ carrier

(2009) Tung-Yi Tsai et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

In Vitro Characterization of AtsB, a Radical SAM Formylglycine-Generating Enzyme That Contains Three [4Fe-4S] Clusters†

(2008) Tyler L. Grove et al.   BIOCHEMISTRY

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS