SPASM and Twitch Domains inS-Adenosylmethionine (SAM) Radical Enzymes

The HydG Enzyme Generates an Fe(CO)2(CN) Synthon in Assembly of the FeFe Hydrogenase H-Cluster

(2014) J. M. Kuchenreuther et al.   SCIENCE

Catalysis of a New Ribose Carbon-Insertion Reaction by the Molybdenum Cofactor Biosynthetic Enzyme MoaA

(2013) Angad P. Mehta et al.   BIOCHEMISTRY

Further Characterization of Cys-Type and Ser-Type Anaerobic Sulfatase Maturating Enzymes Suggests a Commonality in the Mechanism of Catalysis

(2013) Tyler L. Grove et al.   BIOCHEMISTRY

Identification of a Cyclic Nucleotide as a Cryptic Intermediate in Molybdenum Cofactor Biosynthesis

(2013) Bradley M. Hover et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two [4Fe-4S] Clusters Containing Radical SAM Enzyme SkfB Catalyze Thioether Bond Formation during the Maturation of the Sporulation Killing Factor

(2013) Leif Flühe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of an Intermediate Methyl Carrier in the Radical S-Adenosylmethionine Methylthiotransferases RimO and MiaB

(2013) Bradley J. Landgraf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

(2013) Daniel P Dowling et al.   Nature Chemical Biology

Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases

(2013) Farhad Forouhar et al.   Nature Chemical Biology

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry

(2013) P. J. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification

(2013) P. J. Goldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural diversity in the AdoMet radical enzyme superfamily

(2012) Daniel P. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identification and function of auxiliary iron–sulfur clusters in radical SAM enzymes

(2012) Nicholas D. Lanz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Emerging themes in radical SAM chemistry

(2012) Krista A Shisler et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

9-Mercaptodethiobiotin Is Generated as a Ligand to the [2Fe–2S]+ Cluster during the Reaction Catalyzed by Biotin Synthase from Escherichia coli

(2012) Corey J. Fugate et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A

(2012) Leif Flühe et al.   Nature Chemical Biology

Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners

(2011) Daniel H Haft   BMC GENOMICS

Structural Insights into Radical Generation by the Radical SAM Superfamily

(2011) Jessica L. Vey et al.   CHEMICAL REVIEWS

Biological Systems Discovery In Silico: Radical S-Adenosylmethionine Protein Families and Their Target Peptides for Posttranslational Modification

(2011) D. H. Haft et al.   JOURNAL OF BACTERIOLOGY

Sulfatases and a RadicalS-Adenosyl-l-methionine (AdoMet) Enzyme Are Key for Mucosal Foraging and Fitness of the Prominent Human Gut Symbiont,Bacteroides thetaiotaomicron

(2011) Alhosna Benjdia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

Interaction of PqqE and PqqD in the pyrroloquinoline quinone (PQQ) biosynthetic pathway links PqqD to the radical SAM superfamily

(2010) Stephen R. Wecksler et al.   CHEMICAL COMMUNICATIONS

Anaerobic sulfatase-maturating enzyme - A mechanistic link with glycyl radical-activating enzymes?

(2010) Alhosna Benjdia et al.   FEBS Journal

Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis

(2010) W.-T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Residues That Control the Reaction Trajectory inS-Adenosylmethionine Radical Enzymes: Mutagenesis of Asparagine 153 and Aspartate 155 inEscherichia coliBiotin Synthase†

(2009) Christine E. Farrar et al.   BIOCHEMISTRY

Characterization of RimO, a New Member of the Methylthiotransferase Subclass of the Radical SAM Superfamily

(2009) Kyung-Hoon Lee et al.   BIOCHEMISTRY

Pyrroloquinoline Quinone Biogenesis: Demonstration That PqqE fromKlebsiella pneumoniaeIs a RadicalS-Adenosyl-l-methionine Enzyme

(2009) Stephen R. Wecksler et al.   BIOCHEMISTRY

ENDOR Spectroscopy Shows That Guanine N1 Binds to [4Fe−4S] Cluster II of theS-Adenosylmethionine-Dependent Enzyme MoaA: Mechanistic Implications

(2009) Nicholas S. Lees et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using Sequence Similarity Networks for Visualization of Relationships Across Diverse Protein Superfamilies

(2009) Holly J. Atkinson et al.   PLoS One

Unexpected electron transfer mechanism upon AdoMet cleavage in radical SAM proteins

(2009) Y. Nicolet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vitro Characterization of AtsB, a Radical SAM Formylglycine-Generating Enzyme That Contains Three [4Fe-4S] Clusters†

(2008) Tyler L. Grove et al.   BIOCHEMISTRY

Mechanistic Study on the Reaction of a Radical SAM Dehydrogenase BtrN by Electron Paramagnetic Resonance Spectroscopy†

(2008) Kenichi Yokoyama et al.   BIOCHEMISTRY

Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination

(2008) Pavla Bojarová et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Anaerobic Sulfatase-maturating Enzymes, First Dual Substrate RadicalS-Adenosylmethionine Enzymes

(2008) Alhosna Benjdia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily

(2008) Abhishek Chatterjee et al.   Nature Chemical Biology