SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity

Chaperoning SNARE assembly and disassembly

(2016) Richard W. Baker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hemophagocytic lymphohistiocytosis caused by dominant-negative mutations in STXBP2 that inhibit SNARE-mediated membrane fusion

(2015) W. A. Spessott et al.   BLOOD

Synaptotagmin-1 Is an Antagonist for Munc18-1 in SNARE Zippering

(2015) Xiaochu Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin

(2015) Yunxiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity

(2015) Misty R. Marshall et al.   JOURNAL OF CELL BIOLOGY

A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly

(2015) R. W. Baker et al.   SCIENCE

The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis

(2015) Chong Shen et al.   Nature Communications

Recurrent turnover of senescent cells during regeneration of a complex structure

(2015) Maximina H Yun et al.   eLife

Analysis of Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL-4) Mutant Proteins Reveals that S-Acylation Is Required for the Function of Syntaxin 11 in Natural Killer Cells

(2014) Andrew L. Hellewell et al.   PLoS One

The Biogenesis of Lysosomes and Lysosome-Related Organelles

(2014) J. P. Luzio et al.   Cold Spring Harbor Perspectives in Biology

Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

(2014) Michael Zick et al.   eLife

An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2

(2014) Martha-Lena Müller et al.   Frontiers in Immunology

Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release

(2013) Peng Zhou et al.   NEURON

Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation

(2013) N.-R. Bin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntaxin binding mechanism and disease-causing mutations in Munc18-2

(2013) Y. Hackmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

(2013) Ulf Matti et al.   Nature Communications

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11

(2012) F. E. Sepulveda et al.   BLOOD

Munc18b/STXBP2 is required for platelet secretion

(2012) R. Al Hawas et al.   BLOOD

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion

(2012) S. Ye et al.   BLOOD

SNAREpin Assembly by Munc18-1 Requires Previous Vesicle Docking by Synaptotagmin 1

(2012) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

(2012) Braden T. Lobingier et al.   MOLECULAR BIOLOGY OF THE CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Membrane Bridging and Hemifusion by Denaturated Munc18

(2011) Yi Xu et al.   PLoS One

A lipid-anchored SNARE supports membrane fusion

(2011) H. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntaxin 11 Binds Vti1b and Regulates Late Endosome to Lysosome Fusion in Macrophages

(2011) Carolin Offenhäuser et al.   TRAFFIC

Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion

(2010) Jiajie Diao et al.   ACS Chemical Neuroscience

Munc18b regulates core SNARE complex assembly and constitutive exocytosis by interacting with the N-peptide and the closed-conformation C-terminus of syntaxin 3

(2010) Ren-Wang Peng et al.   BIOCHEMICAL JOURNAL

Protein Determinants of SNARE-Mediated Lipid Mixing

(2010) Hong Ji et al.   BIOPHYSICAL JOURNAL

Cytotoxic immunological synapses

(2010) Michael L. Dustin et al.   IMMUNOLOGICAL REVIEWS

The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation

(2010) R. Dressel et al.   JOURNAL OF IMMUNOLOGY

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5

(2010) V. Cetica et al.   JOURNAL OF MEDICAL GENETICS

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A role for endobrevin/VAMP8 in CTL lytic granule exocytosis

(2009) Li Shen Loo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Yeast Sec1p Functions before and after Vesicle Docking

(2009) Kristina Hashizume et al.   MOLECULAR BIOLOGY OF THE CELL

Helical extension of the neuronal SNARE complex into the membrane

(2009) Alexander Stein et al.   NATURE

Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide

(2008) Pawel Burkhardt et al.   EMBO JOURNAL