A new approach for the assessment of the toxicity of polyphenol-rich compounds with the use of high content screening analysis

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing

(2016) Laia Tolosa et al.   TOXICOLOGICAL SCIENCES

The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin

(2015) Merve Bacanlı et al.   FOOD AND CHEMICAL TOXICOLOGY

High content analysis: A sensitive tool to detect and quantify the cytotoxic, synergistic and antagonistic effects of chemical contaminants in foods

(2015) R. Clarke et al.   TOXICOLOGY LETTERS

Preconditioning L6 Muscle Cells with Naringin Ameliorates Oxidative Stress and Increases Glucose Uptake

(2015) R. Dhanya et al.   PLoS One

Application of High-Content Analysis in Clinical Cytology for Translational Safety Biomarkers of Drug-Induced Toxicity for Lymphoma Chemotherapy

(2014) Margarida Canelas Domingos et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

High-Content Analysis in Toxicology: Screening Substances for Human Toxicity Potential, Elucidating Subcellular Mechanisms andIn VivoUse as Translational Safety Biomarkers

(2014) Peter J. O'Brien   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Kaempferol, a potential cytostatic and cure for inflammatory disorders

(2014) Peramaiyan Rajendran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Methods Applied to the In Vitro Primary Toxicology Testing of Natural Products: State of the Art, Strengths, and Limits

(2014) Valérian Bunel et al.   PLANTA MEDICA

Preclinical Evidence for the Pharmacological Actions of Naringin: A Review

(2014) Saurabh Bharti et al.   PLANTA MEDICA

High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

(2014) Heather L. Martin et al.   PLoS One

Hormetic mechanisms

(2013) Edward J. Calabrese   CRITICAL REVIEWS IN TOXICOLOGY

A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans

(2013) Frida Gustafsson et al.   TOXICOLOGICAL SCIENCES

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Comparison of PrestoBlue and MTT assays of cellular viability in the assessment of anti-proliferative effects of plant extracts on human endothelial cells

(2013) Magdalena Boncler et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells

(2012) E. Ramesh et al.   FOOD AND CHEMICAL TOXICOLOGY

Shaping the nucleus: Factors and forces

(2012) Alison D. Walters et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Polyphenols from Evening Primrose (Oenothera paradoxa) Defatted Seeds Induce Apoptosis in Human Colon Cancer Caco-2 Cells

(2011) Sylwia Gorlach et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cellular and molecular effects of resveratrol in health and disease

(2011) Wei Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping

(2010) Saji George et al.   ACS Nano

Hormesis is central to toxicology, pharmacology and risk assessment

(2010) Edward J Calabrese   HUMAN & EXPERIMENTAL TOXICOLOGY

High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures

(2010) Lee-Anne B. Rawlinson et al.   JOURNAL OF CONTROLLED RELEASE

Neuronal models for evaluation of proliferation in vitro using high content screening☆

(2010) William R. Mundy et al.   TOXICOLOGY

Translation of novel anti-cancer cytotoxicity biomarkers detected with high content analysis from an in vitro predictive model to an in vivo cell model

(2010) N.T. Lieggi et al.   TOXICOLOGY IN VITRO

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

High-Content Screening as a Universal Tool for Fingerprinting of Cytotoxicity of Nanoparticles

(2008) Edward Jan et al.   ACS Nano

Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis

(2008) Wei Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Biochemical Profiling and Chemometric Analysis of Seventeen UK-Grown Black Currant Cultivars

(2008) Jordi Giné Bordonaba et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids

(2008) Haitao Luo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES