Article
Chemistry, Multidisciplinary
Rajmohamed Mohammed Asik, Chidhambaram Manikkaraja, Karuppusamy Tamil Surya, Natarajan Suganthy, Archunan Priya Aarthy, Domokos Mathe, Muthusamy Sivakumar, Govindaraju Archunan, Parasuraman Padmanabhan, Balazs Gulyas
Summary: This study synthesized silver nanoparticles using L-histidine and characterized them through spectroscopic and microscopic studies. The results showed that the nanoparticles have potential in inhibiting cervical cancer cells, making them promising candidates for cervical cancer therapy.
Article
Integrative & Complementary Medicine
Juan-ni Zeng, Jin-yu Tan, Li Mo
Summary: This study investigated the therapeutic effect of naringin on colorectal cancer (CRC) and the related mechanism. The results showed that naringin could inhibit cell proliferation and promote apoptosis of CRC cells, as well as suppress cell migration. In vivo experiments also demonstrated its inhibitory effect on tumor growth with good bio-compatibility.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Chemistry, Medicinal
Zhenzhen Yuan, Zhao Yang
Summary: The study reveals that naringin can reduce apoptosis in human degenerative nucleus pulposus cells by inhibiting apoptotic pathways and increasing extracellular matrix expression.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Engineering, Environmental
Lingqiao Yan, Hui Chen, Mindan Xie
Summary: Lung cancer is a common cause of death in both males and females, with diagnosis levels closely associated with mortality rates. A new treatment method incorporating drug reconstruction and nanotechnology has shown promising results in targeting lung cancer cells and inhibiting their proliferation.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Oncology
Jie Niu, Jingyu Sun, Yahua Liu, Jun Guo, Xin Zhang, Yajun Lin
Summary: This study explored the anti-tumor activity of GAL in SiHa cells. The results showed that GAL inhibited the proliferation of SiHa cells, induced cell apoptosis, and arrested the cells in the S phase. GAL also inhibited the invasion of SiHa cells and activated the P53 and P21 pathways. In the animal experiment, GAL significantly inhibited the growth of SiHa cell xenograft tumors without affecting weight gain in mice.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Plant Sciences
Asmita Pal, Soumee Sengupta, Rita Kundu
Summary: This study confirms the ethnopharmacological anticancer role of T. racemosa, inhibiting the abnormal proliferation of cervical cancer cells SiHa by inducing G2/M-phase cell cycle arrest and apoptotic cell death. Oxidative stress-mediated double-stranded DNA damage leads to apoptotic cell death through multiple routes, including the PI3K/Akt/NFKB pathway. The abundant alkaloid content of T. racemosa is suggested as the probable responsible cytotoxic principle.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Materials Science, Ceramics
Lisbeth Almeida Ramon, Erick N. de la Cruz Hernandez, Rosendo Lopez Gonzalez, Maria Fernanda Hernandez Landero, Patricia Quintana Owen, Cinthia Garcia Mendoza, Getsemani Morales Mendoza, Mayra Angelica Alvarez Lemus
Summary: During the last decade, nanosized zinc oxide (ZnO) particles have been investigated for their antiproliferative properties in cancer cells. This study focuses on modifying the surface of ZnO with sulfate groups and 1,10-Phenanthroline to enhance its antiproliferative effects against SiHa cervical cancer cell line. The nanoparticles were prepared using sol-gel and precipitation methods, resulting in different particle shapes and sizes. The surface modifications of the nanoparticles led to changes in their zeta potential and hydrodynamic size. In vitro experiments showed that the modified nanoparticles had a synergistic effect, promoting apoptosis and inhibiting cell proliferation in the SiHa cell line.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rivak Punchoo, Greta Dreyer, Tahir S. Pillay
Summary: Preclinical studies have shown that vitamin D metabolites have anticancer effects by inducing apoptosis, inhibiting cell proliferation, and causing cell cycle arrest. In cervical cancer cells, there is an autocrine vitamin D metabolizing system (VDMS) that includes a vitamin D receptor, vitamin D catabolic enzyme (CYP24A1), and an activating enzyme (CYP27B1) for 25-hydroxycholecalciferol (25(OH)D3). This study demonstrates that physiological and supraphysiological doses of 25(OH)D3 inhibit cell growth and induce apoptosis in cervical cancer cells, potentially providing a promising therapeutic option.
Article
Chemistry, Medicinal
Dan Wang, Mengjin Xu, Fan Li, Yi Gao, Hao Sun
Summary: This study demonstrates the potential key targets of BA-induced apoptosis in cervical cancer SiHa cells using an integrated method. The results show that BA significantly reduces the viability of SiHa cells and affects the expression of key proteins involved in apoptosis.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Parasitology
Fei Fei Gao, Juan-Hua Quan, Min A. Lee, Wei Ye, Jae-Min Yuk, Guang-Ho Cha, In-Wook Choi, Young-Ha Lee
Summary: Trichomonas vaginalis induces mitochondrial ROS production, apoptosis, ER stress response, and mitochondrial dysfunction in SiHa cells. Pretreatment with ROS scavenger or ER stress inhibitor can alleviate these abnormalities. T. vaginalis excretory/secretory products also induce abnormal responses in SiHa cells.
PARASITES & VECTORS
(2021)
Article
Environmental Sciences
Shimaa S. Khaled, Mohammed A. Abdel-Gabbar, Hanan Soliman, Noha A. Ahmed, El-Shaymaa El-Nahass, Osama M. Ahmed
Summary: This study aimed to evaluate the preventive effects of naringin, naringenin, and their combination on liver injury induced by Taxol in Wistar rats. Treatment with naringin and/or naringenin reduced the abnormal levels of liver function markers and improved liver histological changes in Taxol-treated rats. The treatments also decreased hepatic lipid peroxidation and increased antioxidant enzyme activities. The naringin and naringenin mixture appeared to be more effective in improving organ function and structural integrity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zirui Zhao, Shilei Yang, Yawen Deng, Liang Wang, Yifen Zhang, Zhenyu Feng, Han Li, Zhongchao Chi, Yunpeng Xie, Deshi Dong
Summary: The study found that Naringin can prevent DOX-related cardiac injury and inhibit oxidative stress, inflammation, and apoptosis in the heart both in vivo and in vitro. These findings suggest that Naringin may serve as a novel approach to prevent cardiac toxicity induced by anthracycline drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Sally Elnawasany, Yusuf A. Haggag, Shahinaz M. Shalaby, Nema A. Soliman, Amira A. EL Saadany, Marwa A. A. Ibrahim, Farid Badria
Summary: This in vitro study evaluated the effect of three natural products, boswellic acids, curcumin, and naringin, and their corresponding nanoparticles on the proliferation of hepatocellular carcinoma (Hep G2) cells. The results showed that the nanoparticles significantly inhibited the growth of Hep G2 cells, providing a potential alternative treatment for liver cancer.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Biochemistry & Molecular Biology
Dogan Albayrak, Oguzhan Doganlar, Suat Erdogan, Meryem Merakli, Ayten Dogan, Pelin Turker, Ayten Bostanci, Zeynep Banu Doganlar
Summary: The study shows that the combination of naringin with tunicamycin and BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells via oxidative stress and the PERK/eIF2 alpha/ATF4/CHOP pathway. This combination therapy strategy may offer a new effective treatment for colon cancer with minimal side effects on healthy cells.
BIOCHEMICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Heesu Kim, Dong Gun Lee
Summary: Naringin-induced mitochondrial damage and dysfunction lead to oxidative stress and apoptosis in Candida albicans.
Article
Energy & Fuels
Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Ali A. Alshatwi
Summary: In this study, cellulose nanocrystal/hydroxyapatite nanostructure (CN/HAP) hybrids were successfully synthesized using Phoenix dactylifera lignocellulosic biomass and eggshell as bio-precursors. The nanohybrids were characterized and found to be non-toxic and biocompatible. Furthermore, the nanohybrids showed increased activity and gene expression related to bone formation. These findings suggest the potential importance of agro-waste-derived CN/HAP hybrids in bone tissue engineering applications.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biochemistry & Molecular Biology
Rajapandiyan Krishnamoorthy, Jegan Athinarayanan, Vaiyapuri Subbarayan Periyasamy, Mohammad A. Alshuniaber, Ghedeir Alshammari, Mohammed Jamal Hakeem, Mohammed Asif Ahmed, Ali A. Alshatwi
Summary: This study investigates the antibacterial activity and mechanism of action of zinc oxide nanoparticles (ZnO NPs) on β-lactam-resistant Gram-negative food pathogens. The results demonstrate that ZnO NPs have broad-spectrum action against these strains, inducing oxidative stress, lipid peroxidation, membrane damage, and ultimately leading to cell death.
Article
Multidisciplinary Sciences
Rajapandiyan Krishnamoorthy, Abdulraheem R. Adisa, Vaiyapuri Subbarayan Periyasamy, Anis Ahamed, Mohammad A. Alshuniaber, Ali A. Alshatwi
Summary: Catechin absorption, bioavailability, and distribution in human tissue and excretion were found to be low, and colonic bacteria were able to degrade catechin. In this study, the antioxidant potential of bacterial transformed catechin metabolites was assessed, and it was observed that these metabolites had lower antioxidant activity. The expression of antioxidant genes GPX1 and POR also showed different patterns between pure catechin and bacterial transformed catechin metabolites.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Ali A. Alshatwi
Summary: This study synthesized lignin nanoparticles (LNPs) from date palm tree biomass and assessed their morphological features and cytocompatibility properties. The results showed that the LNPs derived from date palm tree biomass have good morphological features, cytocompatibility, and antioxidant properties.
Article
Energy & Fuels
Ali A. Alshatwi, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy
Summary: The study developed an integrated biorefinery approach to convert rice husk into different micro/nanostructured materials, including carbon microspheres, lignin/SiO2 nanohybrids, and cellulose nanostructures. The fabricated materials have potential applications in various biomedical fields.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Environmental Sciences
Jegan Athinarayanan, Amjad A. L. Khaibary, Vaiyapuri Subbarayan Periasamy, Khalid A. Alatiah, Ghalia Shamlan, Omer N. Alsawmahi, Ali A. Alshatwi
Summary: Several nano-toxicological studies have assessed the potential health risks of engineered nanostructures, but little is known about nanoscale ingredients in food products. In this study, we examined the physicochemical characteristics of food product isolate E341/E551 and the effects of nanoscale E341 and E551 on human mesenchymal stem cells. Our findings suggest that co-exposure to E341/E551 can increase ROS levels and deplete mitochondrial membrane potential. Long-term over-exposure to E341/E551 may trigger health risks in humans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Jegan Athinarayanan, Amjad A. L. Khaibary, Vaiyapuri Subbarayan Periasamy, Khalid A. Alatiah, Ghalia Shamlan, Ali A. Alshatwi
Summary: Nanostructured materials are widely used in the food industry, but the impact of food-grade nanostructured materials on biological systems is still not well explored. This study evaluated the physicochemical properties of nanoscale ingredients in commercial food products and found that the E341/E171 combination exhibited toxicity on human mesenchymal stem cells at high concentrations. These findings highlight the need for further research on the potential impact of E341/E171 on biological systems.
JOURNAL OF FOOD SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Micek, Joanna Jurek, Marcin Owczarek, Ida Guerrera, Sebastiano Alfio Torrisi, Sabrina Castellano, Giuseppe Grosso, Ali A. Alshatwi, Justyna Godos
Summary: Emerging evidence suggests that diets rich in plant-based foods and beverages may have positive effects on human health in reducing the risk of chronic diseases. This study investigated the association between polyphenol-rich beverage intake and mental health outcomes among adults in the Mediterranean area. The results showed that moderate intake of coffee and tea was associated with lower perceived stress and depressive symptoms, while regular coffee and moderate/regular red wine drinkers were less likely to have depressive symptoms. However, no significant associations were found for the intake of these beverages and sleep quality.
Article
Materials Science, Multidisciplinary
Reem A. Alomari, Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Laila Alharbi, Ali A. Alshatwi
Summary: Nanomedicine is a technology that can improve human health by using nanoscale materials to detect, treat, and prevent diseases. In this study, g-C3N4/silver sulfide nanohybrids were synthesized using a low-cost and environmentally friendly method. The morphological properties of the nanohybrids were examined using SEM and TEM, and their average particle size distribution was determined using DLS analysis. The nanohybrids were modified with folic acid for the photothermal treatment of breast cancer cells, and the results showed high cell death rates. These findings suggest that the modified nanohybrids may be a valuable tool for fighting cancer.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Food Science & Technology
Agnieszka Micek, Ali A. Alshatwi, Nadia Paladino, Ida Guerrera, Giuseppe Grosso, Sabrina Castellano, Justyna Godos
Summary: Research suggests that consuming plant-based foods and beverages rich in (poly)phenols may play a role in preventing cognitive disorders. This study examined the association between the consumption of (poly)phenol-rich beverages, such as wine and beer, resveratrol intake, and cognitive status in older adults. The findings showed that higher consumption of red wine was associated with lower odds of cognitive impairment, while only the highest intake of white wine was linked to lower odds of cognitive impairment. No significant results were found for beer intake. Higher resveratrol intake was also associated with lower odds of cognitive impairment. In conclusion, consuming (poly)phenol-rich beverages may have a positive impact on cognition in older adults.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Alhanouf Mohammed Al-dossari, Laila Naif Al-Harbi, Norah M. Al-Otaibi, Abdullah Almubarak, Ahmed Tayseer Almnaizel, Ghedeir M. Alshammari, Ghalia Shamlan, Ali A. Alshatwi, Afaf El-Ansary
Summary: This study investigated the effects of goat's milk compared to cow's milk on autistic features in a rat model of autism. The results showed that goat's milk had a positive effect on social interaction. However, further research and clinical trials are needed.
Article
Biochemistry & Molecular Biology
Pandurangan Subash-Babu, Sahar Abdulaziz AlSedairy, Manal Abdulaziz Binobead, Ali A. Alshatwi
Summary: Luteolin-7-O-rutinoside protects RIN-5F cells from high-glucose-induced toxicity, improves insulin secretion, and promotes glucose absorption and homeostasis. It also has significant effects on gene expression and signaling proteins associated with glucose uptake in L6 myotubes.
Article
Nutrition & Dietetics
Agnieszka Micek, Walter Currenti, Cristiana Mignogna, Alice Rosi, Ignazio Barbagallo, Ali A. Alshatwi, Daniele Del Rio, Pedro Mena, Justyna Godos
Summary: This study found that anthocyanins in 100% fruit juices may mediate the potential beneficial effects on blood lipids, with an increase in anthocyanins related to a decrease in total cholesterol and LDL cholesterol.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Salvatore Sciacca, Arturo Lo Giudice, Maria Giovanna Asmundo, Sebastiano Cimino, Ali A. Alshatwi, Giuseppe Morgia, Matteo Ferro, Giorgio Ivan Russo
Summary: This study assessed the relationship between the level of food processing and prostate cancer severity. It found that individuals who consumed more unprocessed/minimally processed foods were less likely to have greater prostate cancer severity, while a borderline association was found between higher consumption of ultra-processed foods and greater prostate cancer severity. However, these associations were not significant after adjusting for potential confounding factors.
Article
Biotechnology & Applied Microbiology
Sahar Abdulaziz AlSedairy, Laila Naif Al-Harbi, Manal Abdulaziz Binobead, Jegan Athinarayanan, Shaista Arzoo, Dalia Saade Al-Tamimi, Ghalia Shamlan, Ali Abdullah Alshatwi, Vaiyapuri Subbarayan Periasamy
Summary: This study investigated the mechanism involved in silencing the CYP2R1 gene in normal and obese Saudi women patients. The results showed that hypermethylation of specific sites in the CYP2R1 gene was significantly associated with body weight, BMI, waist circumference, LDL and total cholesterol levels. Additionally, a correlation between a specific site in the CYP27B1 gene and vitamin D levels was observed. This study indicates a potential role of hypermethylation in the regulation of gene expression and the risk of obesity and vitamin D metabolism.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2023)
