Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)
出版年份 2017 全文链接
标题
Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)
作者
关键词
Cholesterol, Phosphorylation, Biosynthesis, Sterols, Gene expression, Transcriptional control, Ubiquitination, Polymerase chain reaction
出版物
PLoS One
Volume 12, Issue 10, Pages e0187168
出版商
Public Library of Science (PLoS)
发表日期
2017-10-27
DOI
10.1371/journal.pone.0187168
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Structure, biochemistry, and biology of PAK kinases
- (2017) Rakesh Kumar et al. GENE
- Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum
- (2017) Natalia Mast et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SHANK proteins: roles at the synapse and in autism spectrum disorder
- (2017) Patricia Monteiro et al. NATURE REVIEWS NEUROSCIENCE
- Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease
- (2017) Natalia Mast et al. NEUROPHARMACOLOGY
- Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond
- (2016) Miguel Moutinho et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
- (2016) Miguel Moutinho et al. Scientific Reports
- The Influence of Na+, K+-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence
- (2016) Paula F. Kinoshita et al. Frontiers in Physiology
- Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting
- (2015) Curtis D. Hodge et al. ACS Chemical Biology
- CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease
- (2015) Fathia Djelti et al. BRAIN
- Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau
- (2015) Yuyoung Joo et al. FASEB JOURNAL
- LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery
- (2015) Anna Brachet et al. JOURNAL OF CELL BIOLOGY
- Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis
- (2015) Joseph B. Lin et al. JOURNAL OF LIPID RESEARCH
- Histone post-translational modifications in frontal cortex from human donors with Alzheimer’s disease
- (2015) Kyle W. Anderson et al. Clinical Proteomics
- Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain
- (2015) Kyle W. Anderson et al. PLoS One
- Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
- (2014) Ahmed A. Saeed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The tubulin code: Molecular components, readout mechanisms, and functions
- (2014) Carsten Janke JOURNAL OF CELL BIOLOGY
- Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling
- (2014) Juanfei Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ubiquitin Ligases in Cholesterol Metabolism
- (2014) Wei Jiang et al. Diabetes & Metabolism Journal
- Lipids, LXRs and prostate cancer: Are HDACs a new link?
- (2013) Jean-Joseph Hoang et al. BIOCHEMICAL PHARMACOLOGY
- Interaction of 14-3-3ζ with Microtubule-Associated Protein Tau within Alzheimer’s Disease Neurofibrillary Tangles
- (2013) Hamid Y. Qureshi et al. BIOCHEMISTRY
- Apolipoprotein A-II is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes
- (2013) Sira Fatoumata Maïga et al. BIOCHIMIE
- The role of signalling in cellular cholesterol homeostasis
- (2013) Winnie Luu et al. IUBMB LIFE
- Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice
- (2013) Natalia Mast et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RabGEFs are a major determinant for specific Rab membrane targeting
- (2013) Julia Blümer et al. JOURNAL OF CELL BIOLOGY
- On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic andCyp27a1−/−mice
- (2013) Zeina Ali et al. JOURNAL OF LIPID RESEARCH
- The roles of protein kinases in learning and memory
- (2013) K. P. Giese et al. LEARNING & MEMORY
- The ABCs of membrane transporters in health and disease (SLC series): Introduction
- (2013) Matthias A. Hediger et al. MOLECULAR ASPECTS OF MEDICINE
- Regulation of Presynaptic Anchoring of the Scaffold Protein Bassoon by Phosphorylation-Dependent Interaction with 14-3-3 Adaptor Proteins
- (2013) Markus S. Schröder et al. PLoS One
- Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux
- (2013) Maria João Nunes et al. PLoS One
- Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses
- (2012) Nathanael J. Spann et al. CELL
- Cholesterol loss during glutamate-mediated excitotoxicity
- (2012) Alejandro O Sodero et al. EMBO JOURNAL
- AMPK Enhances Insulin-Stimulated GLUT4 Regulation via Lowering Membrane Cholesterol
- (2012) Kirk M. Habegger et al. ENDOCRINOLOGY
- AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
- (2011) Yu Li et al. Cell Metabolism
- The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
- (2011) Walter L. Miller et al. ENDOCRINE REVIEWS
- Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo
- (2011) M. Shafaati et al. JOURNAL OF INTERNAL MEDICINE
- Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging
- (2011) Alejandro O. Sodero et al. JOURNAL OF NEUROCHEMISTRY
- Role of Rab GTPases in Membrane Traffic and Cell Physiology
- (2011) Alex H. Hutagalung et al. PHYSIOLOGICAL REVIEWS
- Cholesterol metabolism in neurons and astrocytes
- (2011) Frank W. Pfrieger et al. PROGRESS IN LIPID RESEARCH
- Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression ofCYP46A1gene transcription
- (2010) Maria João Nunes et al. JOURNAL OF NEUROCHEMISTRY
- ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
- (2010) E. Y. Bryleva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acyl-coenzyme A:cholesterol acyltransferases
- (2009) Ta-Yuan Chang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo
- (2009) Marjan Shafaati et al. JOURNAL OF LIPID RESEARCH
- Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease
- (2009) Eloise Hudry et al. MOLECULAR THERAPY
- Liver X receptor activation restores memory in aged AD mice without reducing amyloid
- (2009) Tim Vanmierlo et al. NEUROBIOLOGY OF AGING
- LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor
- (2009) Noam Zelcer et al. SCIENCE
- Strategy combining separation of isotope-labeled unfolded proteins and matrix-assisted laser desorption/ionization mass spectrometry analysis enables quantification of a wide range of serum proteins
- (2008) Wei-Li Liao et al. ANALYTICAL BIOCHEMISTRY
- Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors
- (2008) Marjan Shafaati et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Rab GTPases and their roles in brain neurons and glia
- (2008) Ee Ling Ng et al. BRAIN RESEARCH REVIEWS
- Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
- (2008) Denise M.O. Ramirez et al. JOURNAL OF COMPARATIVE NEUROLOGY
- Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
- (2008) Michael S. Brown et al. JOURNAL OF LIPID RESEARCH
- Transcriptional regulation of the humanCYP46A1brain-specific expression by Sp transcription factors
- (2008) Ins Milagre et al. JOURNAL OF NEUROCHEMISTRY
- Cholesterol Loss Enhances TrkB Signaling in Hippocampal Neurons Aging in Vitro
- (2008) Mauricio G. Martin et al. MOLECULAR BIOLOGY OF THE CELL
- Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
- (2008) T. Kotti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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