Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity

Type 2 diabetes mellitus disease risk genes identified by genome wide copy number variation scan in normal populations

(2016) Manasa Prabhanjan et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Systems toxicology of chemically induced liver and kidney injuries: histopathology-associated gene co-expression modules

(2016) Jerez A. Te et al.   JOURNAL OF APPLIED TOXICOLOGY

Iron overload in hereditary tyrosinemia type 1 induces liver injury through the Sp1/Tfr2/hepcidin axis

(2016) Wen-Dai Bao et al.   JOURNAL OF HEPATOLOGY

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

Therapeutic targeting of tetraspanin8 in epithelial ovarian cancer invasion and metastasis

(2016) C S Park et al.   ONCOGENE

Recommendations from the INHAND Apoptosis/Necrosis Working Group

(2016) Susan A. Elmore et al.   TOXICOLOGIC PATHOLOGY

Integrating Publicly Available Data to Generate Computationally Predicted Adverse Outcome Pathways for Fatty Liver

(2016) Shannon M. Bell et al.   TOXICOLOGICAL SCIENCES

Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

(2016) Jeffrey J. Sutherland et al.   PLoS Computational Biology

Over-expression of tetraspanin 8 in malignant glioma regulates tumor cell progression

(2015) Si-Jian Pan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An HNF1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells

(2015) Hui Qian et al.   CELL RESEARCH

Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts

(2015) Alexis Poncy et al.   DEVELOPMENTAL BIOLOGY

CO-029 is overexpressed in gastric cancer and mediates the effects of EGF on gastric cancer cell proliferation and invasion

(2015) HONGYU ZHU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond

(2015) Ulrich Beuers et al.   JOURNAL OF HEPATOLOGY

The yin and yang of evasion and immune activation in HCC

(2015) Oxana V. Makarova-Rusher et al.   JOURNAL OF HEPATOLOGY

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging and Disease-Specific Mechanisms of Hepatic Stellate Cell Activation

(2015) Michael Wallace et al.   SEMINARS IN LIVER DISEASE

SOX4 is associated with poor prognosis in cholangiocarcinoma

(2014) Weishan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

Biomarkers of liver cell death

(2014) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

(2014)   NATURE BIOTECHNOLOGY

Can you trust your animal study data?

(2014) Ian S. Peers et al.   NATURE REVIEWS DRUG DISCOVERY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Open TG-GATEs: a large-scale toxicogenomics database

(2014) Yoshinobu Igarashi et al.   NUCLEIC ACIDS RESEARCH

Characterization of Chemically Induced Liver Injuries Using Gene Co-Expression Modules

(2014) Gregory J. Tawa et al.   PLoS One

Application of RNA interference to improve mechanistic understanding of omics responses to a hepatotoxic drug in primary rat hepatocytes

(2014) M. Adler et al.   TOXICOLOGY

Role of Nrf2 in chronic liver disease

(2014) Wei Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Dynamic reciprocity: the role of annexin A2 in tissue integrity

(2014) Jessica K. Hitchcock et al.   Journal of Cell Communication and Signaling

Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches

(2013) Romina Lomonaco et al.   DRUGS

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion

(2013) Michael J. Williams et al.   GASTROENTEROLOGY

Mechanism of Hepatitis C Virus (HCV)-induced Osteopontin and Its Role in Epithelial to Mesenchymal Transition of Hepatocytes

(2013) Jawed Iqbal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differentiation of progenitors in the liver: a matter of local choice

(2013) Luke Boulter et al.   JOURNAL OF CLINICAL INVESTIGATION

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Biliary Proliferative Lesions in the Sprague-Dawley Rat

(2013) James R. Hailey et al.   TOXICOLOGIC PATHOLOGY

Systems Pharmacology to Predict Drug Toxicity: Integration Across Levels of Biological Organization

(2012) Jane P.F. Bai et al.   Annual Review of Pharmacology and Toxicology

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Relating Molecular Properties and in Vitro Assay Results to in Vivo Drug Disposition and Toxicity Outcomes

(2012) Jeffrey J. Sutherland et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

(2012) Andrea Califano et al.   NATURE GENETICS

Tetraspanin CO-029 Inhibits Colorectal Cancer Cell Movement by Deregulating Cell-Matrix and Cell-Cell Adhesions

(2012) Qiusha Guo et al.   PLoS One

A Decade of Toxicogenomic Research and Its Contribution to Toxicological Science

(2012) Minjun Chen et al.   TOXICOLOGICAL SCIENCES

Novel insight into mechanisms of cholestatic liver injury

(2012) Benjamin L Woolbright   WORLD JOURNAL OF GASTROENTEROLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Boosting Signal-to-Noise in Complex Biology: Prior Knowledge Is Power

(2011) Trey Ideker et al.   CELL

A review of the use ofin silicomethods to predict the chemistry of molecular initiating events related to drug toxicity

(2011) Claire M Ellison et al.   Expert Opinion on Drug Metabolism & Toxicology

Investigation of Correlation Among Safety Biomarkers in Serum, Histopathological Examination, and Toxicogenomics

(2011) Tao Wang et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro

(2010) Wonhee Hur et al.   CARCINOGENESIS

SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning

(2010) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Consistency of predictive signature genes and classifiers generated using different microarray platforms

(2010) X Fan et al.   PHARMACOGENOMICS JOURNAL

The Evolution of Bioinformatics in Toxicology: Advancing Toxicogenomics

(2010) C. A. Afshari et al.   TOXICOLOGICAL SCIENCES

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Application of connectivity mapping in predictive toxicology based on gene-expression similarity

(2009) Joshua L. Smalley et al.   TOXICOLOGY