标题
Nonalcoholic Fatty Liver Disease: Current Issues and Novel Treatment Approaches
作者
关键词
Metformin, NASH, Pioglitazone, Exenatide, Pentoxifylline
出版物
DRUGS
Volume 73, Issue 1, Pages 1-14
出版商
Springer Nature
发表日期
2013-01-11
DOI
10.1007/s40265-012-0004-0
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Transient Elastography for the Noninvasive Assessment of Liver Fibrosis: A Multicentre Canadian Study
- (2016) Robert P Myers et al. CANADIAN JOURNAL OF GASTROENTEROLOGY
- Mechanisms for Insulin Resistance: Common Threads and Missing Links
- (2012) Varman T. Samuel et al. CELL
- The Inflammasome Puts Obesity in the Danger Zone
- (2012) Rinke Stienstra et al. Cell Metabolism
- The challenge of managing dyslipidemia in patients with nonalcoholic fatty liver disease
- (2012) Fernando Bril et al. Clinical Lipidology
- Prevalence of Prediabetes and Diabetes and Metabolic Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD)
- (2012) C. Ortiz-Lopez et al. DIABETES CARE
- Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications
- (2012) Kenneth Cusi GASTROENTEROLOGY
- The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
- (2012) Naga Chalasani et al. HEPATOLOGY
- Metformin for Liver Cancer Prevention in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis
- (2012) Zhi-Jiang Zhang et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Potential for statins in the chemoprevention and management of hepatocellular carcinoma
- (2012) Amedeo Lonardo et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
- (2012) György Baffy et al. JOURNAL OF HEPATOLOGY
- Evolution of nonalcoholic fatty liver disease recurrence after liver transplantation
- (2012) Deepa T. Patil et al. LIVER TRANSPLANTATION
- Randomized Placebo-Controlled Clinical Trial of Lorcaserin for Weight Loss in Type 2 Diabetes Mellitus: The BLOOM-DM Study
- (2012) Patrick M. O'Neil et al. Obesity
- Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
- (2011) G. Vernon et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Lipid Targets During Statin Treatment in Dyslipidemic Patients Affected by Nonalcoholic Fatty Liver Disease
- (2011) Lorenzo Maroni et al. AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease
- (2011) Nishanth E. Sunny et al. Cell Metabolism
- Some inflammatory cytokine levels, iron metabolism and oxidan stress markers in subjects with nonalcoholic steatohepatitis
- (2011) Sema Uysal et al. CLINICAL BIOCHEMISTRY
- Insulin Resistance and Other Metabolic Risk Factors in the Pathogenesis of Hepatocellular Carcinoma
- (2011) Asma Siddique et al. Clinics in Liver Disease
- Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
- (2011) Anabela P. Rolo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
- (2011) K. Hallsworth et al. GUT
- Role of ethnicity in overweight and obese patients with nonalcoholic steatohepatitis
- (2011) Romina Lomonaco et al. HEPATOLOGY
- Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
- (2011) Claudia O. Zein et al. HEPATOLOGY
- Pathologic criteria for nonalcoholic steatohepatitis: Interprotocol agreement and ability to predict liver-related mortality
- (2011) Zobair M. Younossi et al. HEPATOLOGY
- Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
- (2011) Shelby Sullivan et al. HEPATOLOGY
- Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
- (2011) Romina Lomonaco et al. HEPATOLOGY
- Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: A systematic review and meta-analysis of cohort studies
- (2011) Chenggang Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents
- (2011) Joel E. Lavine JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Interrelationship between Fatty Liver and Insulin Resistance in the Development of Type 2 Diabetes
- (2011) Ki-Chul Sung et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review
- (2011) Christian Thoma et al. JOURNAL OF HEPATOLOGY
- Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial
- (2011) Kishore M Gadde et al. LANCET
- Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
- (2011) Gianluca Svegliati-Baroni et al. LIVER INTERNATIONAL
- Systematic review of performance of non-invasive biomarkers in the evaluation of non-alcoholic fatty liver disease
- (2011) Michael H. Miller et al. LIVER INTERNATIONAL
- GLP-1 Analogs Reduce Hepatocyte Steatosis and Improve Survival by Enhancing the Unfolded Protein Response and Promoting Macroautophagy
- (2011) Shvetank Sharma et al. PLoS One
- Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
- (2011) Sung Hee Choi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Nonalcoholic fatty liver disease in type 2 diabetes mellitus
- (2011) Kenneth Cusi Current Opinion in Endocrinology Diabetes and Obesity
- Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis
- (2010) M. O. Rakoski et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Exenatide in the Treatment of Diabetic Patients With Non-Alcoholic Steatohepatitis: A Case Series
- (2010) Patrick R Kenny et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Atorvastatin and Antioxidants for the Treatment of Nonalcoholic Fatty Liver Disease: The St Francis Heart Study Randomized Clinical Trial
- (2010) Temitope Foster et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
- (2010) Giovanni Musso et al. ANNALS OF MEDICINE
- Newly diagnosed diabetes mellitus as a risk factor for serious liver disease
- (2010) L. Porepa et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma
- (2010) Manal M. Hassan et al. CANCER
- The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes
- (2010) Kenneth Cusi Current Diabetes Reports
- Effect of a 12-Month Intensive Lifestyle Intervention on Hepatic Steatosis in Adults With Type 2 Diabetes
- (2010) M. Lazo et al. DIABETES CARE
- Genetic and Environmental Susceptibility to Non-Alcoholic Fatty Liver Disease
- (2010) Christopher Paul Day DIGESTIVE DISEASES
- The Natural History of Non-Alcoholic Fatty Liver Disease
- (2010) Stephen Caldwell et al. DIGESTIVE DISEASES
- Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
- (2010) Christopher D. Williams et al. GASTROENTEROLOGY
- Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years
- (2010) V. W.-S. Wong et al. GUT
- Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
- (2010) Nitika Arora Gupta et al. HEPATOLOGY
- Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
- (2010) Brad Q. Starley et al. HEPATOLOGY
- Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease
- (2010) Brent A. Neuschwander-Tetri et al. HEPATOLOGY
- Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites
- (2010) Brent A. Neuschwander-Tetri HEPATOLOGY
- Effect of Fenofibrate and Niacin on Intrahepatic Triglyceride Content, Very Low-Density Lipoprotein Kinetics, and Insulin Action in Obese Subjects with Nonalcoholic Fatty Liver Disease
- (2010) Elisa Fabbrini et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Fenofibrate Reduces Systemic Inflammation Markers Independent of Its Effects on Lipid and Glucose Metabolism in Patients with the Metabolic Syndrome
- (2010) Renata Belfort et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH
- (2010) Yuki Kimura et al. JOURNAL OF GASTROENTEROLOGY
- Postprandial insulin secretion pattern is associated with histological severity in non-alcoholic fatty liver disease patients without prior known diabetes mellitus
- (2010) Yuki Kimura et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Postprandial hyperinsulinemia is universal in non-diabetic patients with nonalcoholic fatty liver disease
- (2010) Jayani Manchanayake et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
- (2010) Vasilios G Athyros et al. LANCET
- Plasma metabolomic profile in nonalcoholic fatty liver disease
- (2010) Satish C. Kalhan et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- (2010) Arun J. Sanyal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
- (2010) NEW ENGLAND JOURNAL OF MEDICINE
- Novel Insights into the Pathophysiology of Nonalcoholic Fatty Liver Disease
- (2010) Ariel Feldstein SEMINARS IN LIVER DISEASE
- Non-Alcoholic Fatty Liver Disease: Is Bariatric Surgery the Answer?
- (2009) Anjana A. Pillai et al. Clinics in Liver Disease
- Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis
- (2009) Kenneth Cusi Clinics in Liver Disease
- Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
- (2009) J. Jendle et al. DIABETES OBESITY & METABOLISM
- Statins Are Associated With a Reduced Risk of Hepatocellular Carcinoma in a Large Cohort of Patients With Diabetes
- (2009) Hashem B. El–Serag et al. GASTROENTEROLOGY
- Dietary Fat and Carbohydrates Differentially Alter Insulin Sensitivity During Caloric Restriction
- (2009) Erik Kirk et al. GASTROENTEROLOGY
- Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease
- (2009) Philippe Mathurin et al. GASTROENTEROLOGY
- The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
- (2009) A E Feldstein et al. GUT
- Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
- (2009) Elisa Fabbrini et al. HEPATOLOGY
- Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis
- (2009) Stephen H. Caldwell et al. HEPATOLOGY
- Abnormal hepatic energy homeostasis in type 2 diabetes
- (2009) Julia Szendroedi et al. HEPATOLOGY
- Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study
- (2009) Ariel E. Feldstein et al. HEPATOLOGY
- Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
- (2009) Cecilia Söderberg et al. HEPATOLOGY
- Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss
- (2009) Nathan A. Johnson et al. HEPATOLOGY
- A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis
- (2009) Austin Nelson et al. JOURNAL OF CLINICAL GASTROENTEROLOGY
- Influence of ethnicity on histological differences in non-alcoholic fatty liver disease
- (2009) Smruti R. Mohanty et al. JOURNAL OF HEPATOLOGY
- Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
- (2009) Nina F. Schwenzer et al. JOURNAL OF HEPATOLOGY
- Alanine aminotransferase, γ-glutamyltransferase (GGT) and all-cause mortality: results from a population-based Danish twins study alanine aminotransferase, GGT and mortality in elderly twins
- (2009) Abigail Fraser et al. LIVER INTERNATIONAL
- Diet and Exercise Interventions Reduce Intrahepatic Fat Content and Improve Insulin Sensitivity in Obese Older Adults
- (2009) Krupa Shah et al. Obesity
- Final results of a long-term, clinical follow-up in fatty liver patients
- (2009) Sanne Dam-Larsen et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Metformin in patients with non-alcoholic fatty liver disease: A randomized, controlled trial
- (2009) John Willy Haukeland et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Cytokeratin-18 fragments and biomarkers of the metabolic syndrome in nonalcoholic steatohepatitis
- (2009) Yusuf Yilmaz et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis
- (2008) R. LOOMBA et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Cytokeratin 18 Fragment Levels as a Noninvasive Biomarker for Nonalcoholic Steatohepatitis in Bariatric Surgery Patients
- (2008) Dima L. Diab et al. Clinical Gastroenterology and Hepatology
- Long-Term Follow-Up of Patients With Nonalcoholic Fatty Liver
- (2008) Nila Rafiq et al. Clinical Gastroenterology and Hepatology
- A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease
- (2008) C. Fernández-Miranda et al. DIGESTIVE AND LIVER DISEASE
- Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis
- (2008) Guruprasad P. Aithal et al. GASTROENTEROLOGY
- Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
- (2008) M Manco et al. GUT
- High cardiorespiratory fitness is an independent predictor of the reduction in liver fat during a lifestyle intervention in non-alcoholic fatty liver disease
- (2008) K Kantartzis et al. GUT
- Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial
- (2008) Stephen A. Harrison et al. HEPATOLOGY
- A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)
- (2008) Yin-Mei Lee et al. Hepatology International
- Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
- (2008) Deborah M. Muoio et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
- (2008) Rury R. Holman et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH)
- (2008) Zobair M. Younossi et al. OBESITY SURGERY
- Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease
- (2007) Elisa Fabbrini et al. GASTROENTEROLOGY
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