MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts

(2017) Vera Adam-Vizi et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways

(2016) Qichao Huang et al.   Autophagy

The mitochondrial calcium uniporter regulates breast cancer progression via HIF‐1α

(2016) Anna Tosatto et al.   EMBO Molecular Medicine

Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration

(2015) Shihao Tang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

(2015) Laura Hakanpaa et al.   Nature Communications

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

(2015) Aritro Nath et al.   Scientific Reports

Inhibition of store-operated calcium entry in microglia by helminth factors: implications for immune suppression in neurocysticercosis

(2014) Yuyang Sun et al.   Journal of Neuroinflammation

Disulfiram Eradicates Tumor-Initiating Hepatocellular Carcinoma Cells in ROS-p38 MAPK Pathway-Dependent and -Independent Manners

(2014) Tetsuhiro Chiba et al.   PLoS One

Mitochondrial Calcium Uniporter Activity Is Dispensable for MDA-MB-231 Breast Carcinoma Cell Survival

(2014) Duane D. Hall et al.   PLoS One

Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells

(2013) Merril C. Curry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial dysfunction represses HIF-1α protein synthesis through AMPK activation in human hepatoma HepG2 cells

(2013) Chia-Chi Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Trop-2 Promotes Prostate Cancer Metastasis By Modulating  1 Integrin Functions

(2013) M. Trerotola et al.   CANCER RESEARCH

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

Probing Novel Roles of the Mitochondrial Uniporter in Ovarian Cancer Cells Using Nanoparticles

(2013) Rochelle R. Arvizo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Wentilactone B induces G2/M phase arrest and apoptosis via the Ras/Raf/MAPK signaling pathway in human hepatoma SMMC-7721 cells

(2013) Z Zhang et al.   Cell Death & Disease

Downregulation of the Mitochondrial Calcium Uniporter by Cancer-Related miR-25

(2012) Saverio Marchi et al.   CURRENT BIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Compartmentation of NAD+ -dependent signalling

(2011) Friedrich Koch-Nolte et al.   FEBS LETTERS

Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice

(2011) Xin Zeng et al.   HEPATOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Vitamin B3, the nicotinamide adenine dinucleotides and aging

(2010) Ping Xu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Mitogen-activated protein kinases in hepatocellular carcinoma development

(2010) Lihua Min et al.   SEMINARS IN CANCER BIOLOGY

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species

(2008) Tianzheng Yu et al.   CARDIOVASCULAR RESEARCH

NAD+ and NADH in ischemic brain injury

(2007) Weihai Ying   Frontiers in Bioscience-Landmark