Article
Biochemistry & Molecular Biology
Yigang Wang, Panpan Huang, Yanping Hu, Keni Guo, Xiaoyuan Jia, Biao Huang, Xinyuan Liu, Xianglei He, Fang Huang
Summary: TSLC1, identified as a tumor suppressor for lung cancer, can inhibit HCC cell growth, migration, and invasion by downregulating the Wnt signaling pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Oncology
Fang Dai, Peng-Bo Zhang, Qiang Feng, Xin-Yan Pan, Shu-Ling Song, Jing Cui, Ju-Lun Yang
Summary: A novel strategy combining oncolytic adenovirus with CIK cells for treating Ras-driven liver cancer was developed. The in vivo study showed significantly inhibited tumor growth with little effect on normal organs, indicating relative safety.
Article
Biochemistry & Molecular Biology
Yang Yang, Huali Zhai, Yue Wan, Xiaofang Wang, Hui Chen, Lihou Dong, Taoyun Liu, Guifang Dou, Chutse Wu, Miao Yu
Summary: This study evaluated the effects of pharmaceutical-grade recombinant human HPS on acute liver injury in mice and monkeys. The results showed that HPS treatment significantly reduced hepatocyte death and inflammation, attenuated the development of acute liver failure, and promoted hepatocyte proliferation while preventing apoptosis and oxidative stress. The study suggested the potential of HPS as a novel drug for the treatment of acute liver injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Berivan Gurbuz, Nurdan Guldiken, Philipp Reuken, Lei Fu, Katharina Remih, Christian Preisinger, Radan Bruha, Martin Lenicek, Jaromir Petrtyl, Johanna Reissing, Mahmoud Aly, Malin Fromme, Biaohuan Zhou, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Andreas Stallmach, Tony Bruns, Pavel Strnad
Summary: This study aimed to characterize changes in hepatocellular serum proteins and evaluate their diagnostic value in cirrhosis. Untargeted proteomic analysis of serum from 29 healthy controls and 43 patients with cirrhosis revealed 65 downregulated and 16 upregulated proteins in cirrhosis patients. Hierarchical clustering identified two main clusters and six sub-clusters. The study also found that serum apolipoprotein AI may be a useful prognostic marker in patients with decompensated cirrhosis.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Pengxiang Qiu, Weilong Hou, Haitao Wang, Kimmy Ka Wing Lei, Shaowei Wang, Weiping Chen, Lakhansing Arun Pardeshi, Katherine Prothro, Yashvita Shukla, Samson Sek Man Su, David S. Schrump, Qiang Chen, Chu-Xia Deng, Xiaoling Xu, Ruihong Wang
Summary: Loss of Sirt1 in the liver renders mice resistant to DEN-induced hepatocellular carcinoma (HCC) development by promoting glutathione metabolism. A reductive environment orchestrated by glutathione metabolism can prevent the initiation of HCC.
Article
Endocrinology & Metabolism
Zhicong Zhao, Xia Deng, Jue Jia, Li Zhao, Chenxi Wang, Zhensheng Cai, Chang Guo, Ling Yang, Dong Wang, Suxian Ma, Jialiang Deng, Haoxiang Li, Libin Zhou, Zhigang Tu, Guoyue Yuan
Summary: The study demonstrated that ANGPTL8 improves glucose metabolism in diabetic mice by inhibiting hepatic gluconeogenesis. This suggests that increased expression of ANGPTL8 could be a potential target for preventing and treating type 2 diabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Immunology
Kun Xu, Yaling An, Qunlong Li, Weijin Huang, Yuxuan Han, Tianyi Zheng, Fang Fang, Hui Liu, Chuanyu Liu, Ping Gao, Senyu Xu, Xueyuan Liu, Rong Zhang, Xin Zhao, William J. Liu, Yuhai Bi, Youchun Wang, Dongming Zhou, Qinghan Wang, Wenli Hou, Qianfeng Xia, George F. Gao, Lianpan Dai
Summary: The study shows that AdC7-RBD-tr2 is a promising COVID-19 vaccine candidate with high immunogenicity, capable of inducing both antibody and cellular immune responses. Mucosal administration can induce mucosal immunity, with neutralizing activity against various variants, and effective protection against SARS-CoV-2 challenge.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Oncology
Ling-Li Li, Ze Peng, Qian Hu, Li-Jun Xu, Xin Zou, Dong-Mei Huang, Ping Yi
Summary: Gastric cancer is a complex disease with various causative factors. Global efforts have been made to investigate new therapeutic approaches. Research has shown that berberine inhibits the growth of gastric cancer tumors by potentially downregulating the expression of the HNF4 alpha-WNT5a/beta-catenin signaling pathways.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Zhaoyun Yang, Yan Gao, Kang He, Xin Sui, Junyu Chen, Taiwei Wang, Mengmeng Chen, Zeyu Wang, Jiang Yi, Lijing Zhao
Summary: Exercise can reduce the risk of cancer recurrence and mortality by regulating metabolism and immunity. This study found that voluntary wheel running inhibits the growth of castration-resistant prostate cancer, promotes apoptosis of tumor cells by reducing HMGB1 levels, enhances immune cell infiltration, and suppresses inflammatory response.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Oncology
Fang Liu, Xinglan An, Xu Zhao, Nan Zhang, Biqing Chen, Ziyi Li, Wei Xu
Summary: miR-10b-5p inhibits the proliferation and migration of gastric cancer cells by down-regulating Tiam1, showing a tumor suppressor role in gastric cancer. Additionally, lenti-miR-10b-5p treatment and agomir-10b-5p injection significantly retard tumor growth and induce apoptosis in gastric cancer xenograft experiments.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Veterinary Sciences
Xiaojuan Xue, Zhaorong Yu, Hongyan Jin, Lin Liang, Jiayang Li, Xiaolu Li, Yong Wang, Shangjin Cui, Gang Li
Summary: Three recombinant adenoviruses expressing VSV-G proteins were successfully constructed in this study, inducing both humoral and cellular immune responses in mice and goats. These results provide a foundation for further research on the use of recombinant adenoviruses in vaccines expressing VSV-G.
BMC VETERINARY RESEARCH
(2021)
Article
Microbiology
Lishuang Deng, Sirui Gu, Yao Huang, Yuling Wang, Jun Zhao, Mincai Nie, Lei Xu, Siyuan Lai, Yanru Ai, Zhiwen Xu, Ling Zhu
Summary: African swine fever (ASF) is a highly lethal infectious disease that causes significant economic losses to the pig industry. This study successfully constructed a viral vector using CRISPR/Cas9 gene-editing technology to express important antigenic proteins of ASFV and demonstrated its immunogenicity and safety in mice. The recombinant virus induced specific immune responses and provided complete protection against the virulent PRV strain, suggesting it as a promising viral vector for developing ASFV vaccines.
VETERINARY MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yang Xie, Runzi Sun, Li Gao, Jibin Guan, Jingyuan Wang, Aaron Bell, Junjie Zhu, Min Zhang, Meishu Xu, Peipei Lu, Xinran Cai, Songrong Ren, Pengfei Xu, Satdarshan P. Monga, Xiaochao Ma, Da Yang, Yulan Liu, Binfeng Lu, Wen Xie
Summary: This study found that chronic activation of LXR alpha promotes hepatocellular carcinoma (HCC) by promoting innate immune suppression as a result of accumulation of oxysterols, as well as up-regulation of the IL-6/Janus kinase/STAT3 signaling and complement pathways.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jingyuan Wen, Zhao Huang, Yi Wei, Lin Xue, Yufei Wang, Jingyu Liao, Junnan Liang, Xiaoping Chen, Liang Chu, Bixiang Zhang
Summary: The study found that hsa-miR-27b has a suppressive effect on the growth and metastasis of HCC; by targeting TAB3, hsa-miR-27b can inactivate the NF-kappa B pathway, thus exerting its anti-tumor effect.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Food Science & Technology
Hamid Hashemi Yeganeh, Mohammad Heiat, Marek Kieliszek, Seyed Moayed Alavian, Ehsan Rezaie
Summary: A novel immunotoxin targeting an oncofetal marker on HCC cells was designed and investigated, showing high cytotoxic effects, especially on GPC3-positive cell lines.