A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

(2016) Atsushi Umemura et al.   CANCER CELL

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

New dimension of glucocorticoids in cancer treatment

(2016) Kai-Ti Lin et al.   STEROIDS

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

Cardiac glycosides display selective efficacy for STK11 mutant lung cancer

(2016) Nayoung Kim et al.   Scientific Reports

Dysregulation of the Keap1–Nrf2 pathway in cancer: Figure 1

(2015) Hanna M. Leinonen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Epigenetic regulation of Keap1-Nrf2 signaling

(2015) Yue Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2

(2015) Adedamola Olayanju et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Molecular basis of the Keap1–Nrf2 system

(2015) Takafumi Suzuki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selective glucocorticoid receptor modulation: New directions with non-steroidal scaffolds

(2015) Nora Sundahl et al.   PHARMACOLOGY & THERAPEUTICS

Co-occurring Genomic Alterations Define Major Subsets of KRAS-Mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities

(2015) F. Skoulidis et al.   Cancer Discovery

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

(2014) Jacob M. Kaufman et al.   Journal of Thoracic Oncology

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides

(2014) José Manuel Calderón-Montaño et al.   Biomed Research International

Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination

(2013) B. E. Hast et al.   CANCER RESEARCH

Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury

(2013) Yao-Chun Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials

(2013) M. Slingerland et al.   INVESTIGATIONAL NEW DRUGS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

The in vivo antitumor activity of cardiac glycosides in mice xenografted with human cancer cells is probably an experimental artifact

(2013) J M Calderón-Montaño et al.   ONCOGENE

Glucocorticoid receptor signaling in health and disease

(2013) Mahita Kadmiel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

(2012) A Arlt et al.   ONCOGENE

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

(2012) S Chowdhry et al.   ONCOGENE

Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

(2012) Denise V. Kratschmar et al.   PLoS One

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

(2011) Xiuwen Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention and treatment of systemic glucocorticoid side effects

(2010) Siamak Moghadam-Kia et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis

(2010) Rachel Spokoini et al.   MOLECULAR ENDOCRINOLOGY

β-TrCP Inhibition Reduces Prostate Cancer Cell Growth via Upregulation of the Aryl Hydrocarbon Receptor

(2010) Udi Gluschnaider et al.   PLoS One

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

(2010) Y. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity

(2008) Kah Poh Tan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell lysis with dimethyl sulphoxide produces stable homogeneous solutions in the dichlorofluorescein oxidative stress assay

(2008) Guqi Wang et al.   FREE RADICAL RESEARCH