Article
Neurosciences
Gen-ichi Tasaka, Claudia Maggi, Elham Taha, Adi Mizrahi
Summary: Roughly 20% of neurons in the mouse cortex are inhibitory interneurons (INs), with major subtypes being parvalbumin (PV), somatostatin (SST), and vasoactive intestinal polypeptide (VIP) expressing neurons. Utilizing monosynaptic rabies tracing, researchers compared the presynaptic inputs onto these subtypes in the primary auditory cortex. The local input landscape to SST neurons was more widespread, while the long-range input patterns were generally similar among IN groups, with some specific differences detected.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Elisa N. Falk, Kevin J. Norman, Yury Garkun, Michael P. Demars, Susanna Im, Giulia Taccheri, Jenna Short, Keaven Caro, Sarah E. McCraney, Christina Cho, Milo R. Smith, Hung-Mo Lin, Hiroyuki Koike, Julia Bateh, Priscilla Maccario, Leah Waltrip, Meaghan Janis, Hirofumi Morishita
Summary: This study reveals that dynamic regulation of the nicotinic cholinergic system plays a key role in the maturation of attentional circuit, particularly in the development of top-down frontal neurons. Following adolescence, the decrease in nicotinic tone by upregulation of Lynxl promotes the establishment of attentional behavior in adulthood. Disruption of this key maturational process is observed in a mouse model of fragile X syndrome, but can be rescued by suppressing nicotinic tone through the introduction of Lynxl in top-down projections.
Article
Neurosciences
Kenta M. Hagihara, Ayako Wendy Ishikawa, Yumiko Yoshimura, Yoshiaki Tagawa, Kenichi Ohki
Summary: The study revealed that callosal projection neurons (CPNs) in the mouse visual cortex exhibit specific response properties and local connectivity patterns, indicating that the projection target of long-range projections can predict the response properties and local connections of cortical projection neurons.
Article
Biology
Ryszard Auksztulewicz, Vani Gurusamy Rajendran, Fei Peng, Jan Wilbert Hendrik Schnupp, Nicol Spencer Harper
Summary: This study used invasive recordings to investigate omission responses in the auditory cortex of anesthetized rats. The results showed that omission responses were observed in LFP and AMUA signals, but not in spiking activity. The amplitude of omission response was lower and latency was longer compared to burst-evoked sensory responses, and it increased as the number of preceding bursts increased.
Article
Multidisciplinary Sciences
Miho Kawata, Yu Kodani, Mahito Ohkuma, Ei-ichi Miyachi, Yoko S. Kaneko, Akira Nakashima, Hidetaka Suga, Toshiki Kameyama, Kanako Saito, Hiroshi Nagasaki
Summary: Stem cell-derived hypothalamic neurons can be transplanted orthotopically into the mouse brain and exhibit axonal projections extending along hypothalamic nerve bundles, including projections into the posterior pituitary.
Review
Neurosciences
Tatsuo K. Sato
Summary: The cerebral cortex performs powerful computations through local and long-range connectivity, providing flexibility in computational performance. Long-range connectivity can have facilitatory or suppressive impacts on cortical function, which can be captured by a gain control model.
NEUROSCIENCE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nicholas J. Audette, WenXi Zhou, Alessandro La Chioma, David M. Schneider
Summary: Many sensations experienced by an organism are caused by its own actions. Accurately predicting the sensory features and timing of self-generated stimuli is crucial for various behaviors. Research has shown that neural responses to self-generated sounds in the auditory cortex exhibit frequency-specific suppression, suggesting that movement-based predictions may occur early in sensory processing.
Article
Psychiatry
Stephanie M. Hare, Bhim M. Adhikari, Xiaoming Du, Laura Garcia, Heather Bruce, Peter Kochunov, Jonathan Z. Simon, L. Elliot Hong
Summary: The study found that auditory perceptual disturbances in schizophrenia are associated with deficits in both local and long-range functional connectivity. Reduced ReHo in the left and right putamen, left temporoparietal junction (TPJ), and right hippocampus-pallidum was significantly linked to the severity of APD. Together, local and long-distance connectivity measures explained 40.3% of the variance in APD, with the left TPJ ReHo being the strongest predictor.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Cell Biology
Gregg A. Wildenberg, Matt R. Rosen, Jack Lundell, Dawn Paukner, David J. Freedman, Narayanan Kasthuri
Summary: The study reveals that primate neurons receive fewer excitatory and inhibitory synapses compared to mouse neurons, leading to lower excitatory-to-inhibitory ratios in excitatory neurons. Inhibitory axons have consistent properties in both species, with local and specific innervation of excitatory neurons. Additionally, the penalty for creating and maintaining synapses in artificial neural networks results in a reduction of connections per node, similar to the pattern seen in primate neurons versus mice.
Article
Biochemistry & Molecular Biology
Gustavo Deco, Yonathan Sanz Perl, Peter Vuust, Enzo Tagliazucchi, Henry Kennedy, Morten L. Kringelbach
Summary: The topological features of connectivity, such as long-range exceptions and turbulence, play a crucial role in improving information processing for efficient cortical function.
Article
Neurosciences
Patrick A. Cody, Thanos Tzounopoulos
Summary: Neural adaptation allows the brain to efficiently process sensory signals despite changes in background noise. In the auditory pathway, contrast in background sound levels leads to different neural responses, but mean firing-rates in auditory cortex remain unaffected by sound level contrast. The neuromodulatory mechanisms behind these phenomena are still unknown.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Georgia Calhoun, Chih-Ting Chen, Patrick O. Kanold
Summary: Coordinated functioning of the two cortical hemispheres is crucial for perception. The left hemisphere of the human auditory cortex is specialized for processing speech, while the right hemisphere analyzes spectral content. In mice, virgin female mice show a left-hemisphere bias in response to pup vocalizations, which strengthens with motherhood. However, the establishment of this lateralized function is still unclear. This study developed a widefield imaging microscope to monitor functional responses in both hemispheres of mice simultaneously. The results showed that the secondary auditory cortex in the left hemisphere of both male and virgin female mice exhibited larger responses than the right hemisphere to high-frequency tones and adult vocalizations. Only virgin female mice showed a left-hemisphere bias in response to adult pain calls. The study also found that the development of functional cross-hemispheric connections depends on sensory experience.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Sihao Lu, Grace W. Y. Ang, Mark Steadman, Andriy S. Kozlov
Summary: A central question in sensory neuroscience is how neurons represent complex natural stimuli. Through studying birds and mice, it has been found that neurons in their sensory systems have composite receptive fields. Therefore, our research suggests that composite receptive fields may be a common property of central auditory systems.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Physics, Multidisciplinary
R. Vilela Mendes, Tanya Araujo
Summary: Networks with long-range connections, known as fractional networks, exhibit superdiffusion, Levy flights, and robustness properties that are different from scale-free networks. This study investigates the anomalous superdiffusive and mixed diffusion behavior in such networks, particularly in social networks and modular hierarchical brain networks, and explores the relationship with the nature and density of long-range connections.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2022)
Article
Audiology & Speech-Language Pathology
Magdalena Solyga, Tania Rinaldi Barkat
Summary: This study reveals distinct processing of spectrally simple and complex sounds in the two primary auditory cortices in mice, with A1 neurons responding stronger and faster to spectrally complex tones than AAF neurons. Laminar analysis demonstrates a stronger response of A1 neurons in layer 2/3 to spectrally complex tones compared to neurons in layer 4, indicating important transformation in spectral complexity representation within A1.
Review
Neurosciences
Tomas Hromadka, Anthony M. Zador
CURRENT OPINION IN NEUROBIOLOGY
(2009)
Article
Neurosciences
Hiroki Asari, Anthony M. Zador
JOURNAL OF NEUROPHYSIOLOGY
(2009)
Article
Neurosciences
Tomas Hromadka, Anthony M. Zador, Michael R. DeWeese
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
Alexei A. Koulakov, Tomas Hromadka, Anthony M. Zador
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Yang Yang, Anthony M. Zador
JOURNAL OF NEUROSCIENCE
(2012)
Article
Neurosciences
Santiago Jaramillo, Katharine Borges, Anthony M. Zador
JOURNAL OF NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
Petr Znamenskiy, Anthony M. Zador
Article
Neurosciences
Yang Yang, Michael R. DeWeese, Gonzalo H. Otazu, Anthony M. Zador
NATURE NEUROSCIENCE
(2008)
Article
Neurosciences
Gonzalo H. Otazu, Lung-Hao Tai, Yang Yang, Anthony M. Zador
NATURE NEUROSCIENCE
(2009)
Article
Neurosciences
Santiago Jaramillo, Anthony M. Zador
NATURE NEUROSCIENCE
(2011)
Article
Neurosciences
Hysell V. Oviedo, Ingrid Bureau, Karel Svoboda, Anthony M. Zador
NATURE NEUROSCIENCE
(2010)
Article
Multidisciplinary Sciences
Susana Q. Lima, Tomas Hromadka, Petr Znamenskiy, Anthony M. Zador
Article
Biochemistry & Molecular Biology
Tomas Hromadka, Michael R. DeWeese, Anthony M. Zador
Article
Biochemistry & Molecular Biology
Anthony M. Zador, Joshua Dubnau, Hassana K. Oyibo, Huiqing Zhan, Gang Cao, Ian D. Peikon