Issues related to development of new antiseizure treatments

Basic mechanisms of catastrophic epilepsy – Overview from animal models

(2013) Aristea S. Galanopoulou   BRAIN & DEVELOPMENT

Epilepsy biomarkers

(2013) Jerome Engel et al.   EPILEPSIA

Vigabatrin Inhibits Seizures and mTOR Pathway Activation in a Mouse Model of Tuberous Sclerosis Complex

(2013) Bo Zhang et al.   PLoS One

Evidence-based review on the natural history of the epilepsies

(2012) Dieter Schmidt et al.   CURRENT OPINION IN NEUROLOGY

Commentary on Anticonvulsant Screening Program update: Children are not little adults

(2012) Shlomo Shinnar et al.   EPILEPSIA

The value of blind screening in the Anticonvulsant Screening Program

(2012) Jacqueline French   EPILEPSIA

Comments on the working group’s 2012 review of the Program

(2012) Meir Bialer   EPILEPSIA

The response of NINDS to recommendations from the working group’s 2012 review of the Program

(2012) Rajesh Ranganathan   EPILEPSIA

Searching for new targets for treatment of pediatric epilepsy

(2012) Yoav Noam et al.   EPILEPSY & BEHAVIOR

Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats

(2012) Ajay K. Srivastava et al.   EPILEPSY RESEARCH

The intrahippocampal kainate model of temporal lobe epilepsy revisited: Epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats

(2012) Marta Rattka et al.   EPILEPSY RESEARCH

Adverse effects of antiepileptic drugs

(2012) Piero Perucca et al.   LANCET NEUROLOGY

Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones

(2011) Krzysztof Kamiński et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Expression and function of KCNQ channels in larval zebrafish

(2011) Sally W. Chege et al.   Developmental Neurobiology

Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy

(2011) Marion Bankstahl et al.   EXPERIMENTAL NEUROLOGY

Development of Post-Traumatic Epilepsy after Controlled Cortical Impact and Lateral Fluid-Percussion-Induced Brain Injury in the Mouse

(2011) Tamuna Bolkvadze et al.   JOURNAL OF NEUROTRAUMA

Lamotrigine XR Conversion to Monotherapy: First Study Using a Historical Control Group

(2011) Jacqueline A. French et al.   Neurotherapeutics

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

Synthesis and Anticonvulsant Activity of New N-Mannich Bases Derived from 5-Cyclopropyl-5-phenyl-hydantoins

(2010) Hanna Byrtus et al.   ARCHIV DER PHARMAZIE

Anticonvulsant and proconvulsant actions of 2-deoxy-d-glucose

(2010) Maciej Gasior et al.   EPILEPSIA

In search of models of pharmacoresistant epilepsy

(2010) Abdul Wahab et al.   EPILEPSIA

Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models

(2010) Nicole M. Rowley et al.   EPILEPSY RESEARCH

Drug refractoriness of epileptiform activity in organotypic hippocampal slice cultures depends on the mode of provocation

(2010) Abdul Wahab et al.   EPILEPSY RESEARCH

Association of the severity of cortical damage with the occurrence of spontaneous seizures and hyperexcitability in an animal model of posttraumatic epilepsy

(2010) Irina Kharatishvili et al.   EPILEPSY RESEARCH

ECoG studies of valproate, carbamazepine and halothane in frontal-lobe epilepsy induced by head injury in the rat

(2010) Clifford L. Eastman et al.   EXPERIMENTAL NEUROLOGY

Interictal Spikes Precede Ictal Discharges in an Organotypic Hippocampal Slice Culture Model of Epileptogenesis

(2010) J. Dyhrfjeld-Johnsen et al.   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

Antiepileptic and Antiepileptogenic Performance of Carisbamate after Head Injury in the Rat: Blind and Randomized Studies

(2010) C. L. Eastman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Functional definition of seizure provides new insight into post-traumatic epileptogenesis

(2009) Raimondo D'Ambrosio et al.   BRAIN

Why is the developing brain more susceptible to status epilepticus?

(2009) Antonietta Coppola et al.   EPILEPSIA

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

A Triplet Repeat Expansion Genetic Mouse Model of Infantile Spasms Syndrome, Arx(GCG)10+7, with Interneuronopathy, Spasms in Infancy, Persistent Seizures, and Adult Cognitive and Behavioral Impairment

(2009) M. G. Price et al.   JOURNAL OF NEUROSCIENCE

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

A model of symptomatic infantile spasms syndrome

(2009) Morris H. Scantlebury et al.   NEUROBIOLOGY OF DISEASE

New Developments in Antiepileptic Drug Resistance: An Integrative View

(2009) Dieter Schmidt et al.   Epilepsy Currents

Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures

(2008) K Albus et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effective treatments of prolonged status epilepticus in developing rats

(2008) Henry Hasson et al.   EPILEPSY & BEHAVIOR

Mouse models of humanKCNQ2andKCNQ3mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization

(2008) Nanda A. Singh et al.   JOURNAL OF PHYSIOLOGY-LONDON

A new animal model of infantile spasms with unprovoked persistent seizures

(2007) Chong L. Lee et al.   EPILEPSIA