期刊
CELL
卷 161, 期 3, 页码 450-457出版社
CELL PRESS
DOI: 10.1016/j.cell.2015.03.049
关键词
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资金
- NIH [R01GM098672, R01GM082893, S10RR026814, P50GM082250]
- NSF [DBI-0960271]
- University of California San Francisco Program for Breakthrough Biomedical Research
Until only a few years ago, single-particle electron cryo-microscopy (cryo-EM) was usually not the first choice for many structural biologists due to its limited resolution in the range of nanometer to subnanometer. Now, this method rivals X-ray crystallography in terms of resolution and can be used to determine atomic structures of macromolecules that are either refractory to crystallization or difficult to crystallize in specific functional states. In this review, I discuss the recent breakthroughs in both hardware and software that transformed cryo-microscopy, enabling understanding of complex biomolecules and their functions at atomic level.
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