标题
Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 8, Pages 565-586
出版商
Springer Nature
发表日期
2017-05-05
DOI
10.1038/nrd.2017.33
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The structure of Zika virus NS5 reveals a conserved domain conformation
- (2017) Boxiao Wang et al. Nature Communications
- Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
- (2017) Andre S. Godoy et al. Nature Communications
- Structure and function of the Zika virus full-length NS5 protein
- (2017) Baoyu Zhao et al. Nature Communications
- Characterization of a Novel Murine Model to Study Zika Virus
- (2016) Shannan L. Rossi et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Lactimidomycin is a broad-spectrum inhibitor of dengue and other RNA viruses
- (2016) Margot Carocci et al. ANTIVIRAL RESEARCH
- Optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2: The search for a window for potential therapeutic efficacy
- (2016) Satoru Watanabe et al. ANTIVIRAL RESEARCH
- Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus
- (2016) Luděk Eyer et al. ANTIVIRAL RESEARCH
- Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R–like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells
- (2016) J.E. Fraser et al. ANTIVIRAL RESEARCH
- Novel antiviral activity of bromocriptine against dengue virus replication
- (2016) Fumihiro Kato et al. ANTIVIRAL RESEARCH
- In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses
- (2016) Michael K. Lo et al. ANTIVIRAL RESEARCH
- Zika virus: History, emergence, biology, and prospects for control
- (2016) Scott C. Weaver et al. ANTIVIRAL RESEARCH
- Glycosylation of dengue virus glycoproteins and their interactions with carbohydrate receptors: possible targets for antiviral therapy
- (2016) Fakhriedzwan Idris et al. ARCHIVES OF VIROLOGY
- Dengue vaccine: local decisions, global consequences
- (2016) Hugo López-Gatell et al. BULLETIN OF THE WORLD HEALTH ORGANIZATION
- Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise
- (2016) Jonathan J. Miner et al. CELL
- Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses
- (2016) Bryan C. Mounce et al. Cell Host & Microbe
- A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection
- (2016) Nicholas J. Barrows et al. Cell Host & Microbe
- A Mouse Model of Zika Virus Pathogenesis
- (2016) Helen M. Lazear et al. Cell Host & Microbe
- Approved Antiviral Drugs over the Past 50 Years
- (2016) Erik De Clercq et al. CLINICAL MICROBIOLOGY REVIEWS
- Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus
- (2016) Milind Saudi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Sexual transmission of Zika virus in Germany, April 2016
- (2016) Christina Frank et al. Eurosurveillance
- Src kinases central to T-cell receptor signaling regulate TLR-activated innate immune responses from human T cells
- (2016) Naveen Sharma et al. Innate Immunity
- Long-term outcomes of Murray Valley encephalitis cases in Western Australia: what have we learnt?
- (2016) L. A. Selvey et al. INTERNAL MEDICINE JOURNAL
- Nucleoside Inhibitors of Zika Virus
- (2016) Luděk Eyer et al. JOURNAL OF INFECTIOUS DISEASES
- Host sphingomyelin increases West Nile virus infection in vivo
- (2016) Miguel A. Martín-Acebes et al. JOURNAL OF LIPID RESEARCH
- Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology
- (2016) Christoph Nitsche et al. JOURNAL OF MEDICINAL CHEMISTRY
- 2015 Philip S. Portoghese Medicinal Chemistry Lectureship. Curing Hepatitis C Virus Infection with Direct-Acting Antiviral Agents: The Arc of a Medicinal Chemistry Triumph
- (2016) Nicholas A. Meanwell JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses
- (2016) Bryan C. Mounce et al. JOURNAL OF VIROLOGY
- Zika virus infection in French Polynesia
- (2016) Jean-Marie Jouannic et al. LANCET
- Association between Zika virus and microcephaly in French Polynesia, 2013–15: a retrospective study
- (2016) Simon Cauchemez et al. LANCET
- Zika virus: high infectious viral load in semen, a new sexually transmitted pathogen?
- (2016) Jean Michel Mansuy et al. LANCET INFECTIOUS DISEASES
- Zika virus in the female genital tract
- (2016) Nadia Prisant et al. LANCET INFECTIOUS DISEASES
- Structural basis of potent Zika–dengue virus antibody cross-neutralization
- (2016) Giovanna Barba-Spaeth et al. NATURE
- Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
- (2016) Wanwisa Dejnirattisai et al. NATURE IMMUNOLOGY
- Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
- (2016) Miao Xu et al. NATURE MEDICINE
- The Janus kinase inhibitor ruxolitinib reduces HIV replication in human macrophages and ameliorates HIV encephalitis in a murine model
- (2016) Woldeab B. Haile et al. NEUROBIOLOGY OF DISEASE
- Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection
- (2016) Cristina Asvolinsque Pantaleão Fontes et al. NEURORADIOLOGY
- Zika Virus Infection in Pregnant Women in Rio de Janeiro
- (2016) Patrícia Brasil et al. NEW ENGLAND JOURNAL OF MEDICINE
- Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents
- (2016) Annalaura Brai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
- (2016) Jian Lei et al. SCIENCE
- Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment
- (2016) Neil M. Ferguson et al. SCIENCE
- Thiazolides Elicit Anti-Viral Innate Immunity and Reduce HIV Replication
- (2016) Daria Trabattoni et al. Scientific Reports
- The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model
- (2016) Joanna Zmurko et al. PLoS Neglected Tropical Diseases
- Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques
- (2016) Travis K. Warren et al. PLoS Neglected Tropical Diseases
- Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
- (2016) Siew Pheng Lim et al. PLoS Pathogens
- The crystal structure of Zika virus helicase: basis for antiviral drug design
- (2016) Hongliang Tian et al. Protein & Cell
- BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease
- (2016) Raymond Taylor et al. Journal of Infection and Public Health
- Increase in Reported Prevalence of Microcephaly in Infants Born to Women Living in Areas with Confirmed Zika Virus Transmission During the First Trimester of Pregnancy — Brazil, 2015
- (2016) Wanderson Kleber de Oliveira et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- Male-to-Male Sexual Transmission of Zika Virus — Texas, January 2016
- (2016) D. Trew Deckard et al. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
- Synergistic Suppression of Dengue Virus Replication Using a Combination of Nucleoside Analogs and Nucleoside Synthesis Inhibitors
- (2015) Kim Long Yeo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication
- (2015) Teresa Merino-Ramos et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The search for nucleoside/nucleotide analog inhibitors of dengue virus
- (2015) Yen-Liang Chen et al. ANTIVIRAL RESEARCH
- Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection
- (2015) Jacob Nelson et al. ANTIVIRAL RESEARCH
- Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay
- (2015) Justin Jang Hann Chu et al. ANTIVIRAL RESEARCH
- Targeting dengue virus NS4B protein for drug discovery
- (2015) Xuping Xie et al. ANTIVIRAL RESEARCH
- The dengue virus NS5 protein as a target for drug discovery
- (2015) Siew Pheng Lim et al. ANTIVIRAL RESEARCH
- Dual inhibitors of the dengue and West Nile virus NS2B–NS3 proteases: Synthesis, biological evaluation and docking studies of novel peptide-hybrids
- (2015) Allan Bastos Lima et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection
- (2015) Shuhei Taguwa et al. CELL
- Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues
- (2015) Brian J. Larsen et al. CHEMISTRY-A EUROPEAN JOURNAL
- DDX3 functions in antiviral innate immunity through translational control of PACT
- (2015) Ming-Chih Lai et al. FEBS Journal
- Dengue virus requires the CC-chemokine receptor CCR5 for replication and infection development
- (2015) Rafael E. Marques et al. IMMUNOLOGY
- Reactivation of resolved infection with the hepatitis B virus immune escape mutant G145R during dasatinib treatment for chronic myeloid leukemia
- (2015) Toshihiko Ando et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Detection of Zika virus in saliva
- (2015) Didier Musso et al. JOURNAL OF CLINICAL VIROLOGY
- Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus
- (2015) Xiao-Dan Li et al. JOURNAL OF GENERAL VIROLOGY
- Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery
- (2015) Li-Fong Wang et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH)
- (2015) Hélène Munier-Lehmann et al. JOURNAL OF MEDICINAL CHEMISTRY
- 5′-Silylated 3′-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus
- (2015) Sanjeev Kumar V. Vernekar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue
- (2015) Mira A. M. Behnam et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors
- (2015) Lena F. Weigel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Dengue Virus NS4B Inhibitors
- (2015) Qing-Yin Wang et al. JOURNAL OF VIROLOGY
- Dengue Virus Evolution under a Host-Targeted Antiviral
- (2015) Emily Plummer et al. JOURNAL OF VIROLOGY
- Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway
- (2015) Sowmya Pattabhi et al. JOURNAL OF VIROLOGY
- First report of autochthonous transmission of Zika virus in Brazil
- (2015) Camila Zanluca et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Antiviral drug discovery: broad-spectrum drugs from nature
- (2015) J. P. Martinez et al. NATURAL PRODUCT REPORTS
- Recognition determinants of broadly neutralizing human antibodies against dengue viruses
- (2015) Alexander Rouvinski et al. NATURE
- AVI-7288 for Marburg Virus in Nonhuman Primates and Humans
- (2015) Alison E. Heald et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease
- (2015) Sri Rezeki Hadinegoro et al. NEW ENGLAND JOURNAL OF MEDICINE
- Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses
- (2015) Audrey Stéphanie Richard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Flaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral intervention
- (2015) Joanna Zmurko et al. REVIEWS IN MEDICAL VIROLOGY
- Antiviral Activity of Chloroquine Against Dengue Virus Type 2 Replication inAotusMonkeys
- (2015) Kleber Juvenal Silva Farias et al. VIRAL IMMUNOLOGY
- Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus
- (2015) Turgut E. Aktepe et al. VIROLOGY
- Flaviviral Replication Complex: Coordination between RNA Synthesis and 5’-RNA Capping
- (2015) Valerie Klema et al. Viruses-Basel
- Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance
- (2015) Auda Eltahla et al. Viruses-Basel
- Reaching beyond HIV/HCV: nelfinavir as a potential starting point for broad-spectrum protease inhibitors against dengue and chikungunya virus
- (2015) Soumendranath Bhakat et al. RSC Advances
- Product review on the JE vaccine IXIARO
- (2015) Christa Firbas et al. Human Vaccines & Immunotherapeutics
- Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection
- (2015) Milly M. Choy et al. PLoS Neglected Tropical Diseases
- Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase
- (2015) Noreena L. Sweeney et al. ACS Infectious Diseases
- Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase
- (2015) Matthew Brecher et al. ACS Infectious Diseases
- In Vivo Therapeutic Protection against Influenza A (H1N1) Oseltamivir-Sensitive and Resistant Viruses by the Iminosugar UV-4
- (2015) Eric J. Stavale et al. PLoS One
- NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics
- (2015) Garvita Gupta et al. PLoS One
- Inhibition of Endoplasmic Reticulum-Resident Glucosidases Impairs Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63 Spike Protein-Mediated Entry by Altering the Glycan Processing of Angiotensin I-Converting Enzyme 2
- (2014) Xuesen Zhao et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Bioactive Lipid 4-Hydroxyphenyl Retinamide Inhibits Flavivirus Replication
- (2014) Margot Carocci et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- BCX4430, a Novel Nucleoside Analog, Effectively Treats Yellow Fever in a Hamster Model
- (2014) Justin G. Julander et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Nitazoxanide: A first-in-class broad-spectrum antiviral agent
- (2014) Jean-François Rossignol ANTIVIRAL RESEARCH
- Antiviral activity of lanatoside C against dengue virus infection
- (2014) Yan Yi Cheung et al. ANTIVIRAL RESEARCH
- Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity
- (2014) Siwaporn Boonyasuppayakorn et al. ANTIVIRAL RESEARCH
- Biochemistry and Medicinal Chemistry of the Dengue Virus Protease
- (2014) Christoph Nitsche et al. CHEMICAL REVIEWS
- Anti-Dengue-Virus Activity and Structure-Activity Relationship Studies of Lycorine Derivatives
- (2014) Peng Wang et al. ChemMedChem
- Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus
- (2014) Milind Saudi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Zika virus infection complicated by Guillain-Barré syndrome – case report, French Polynesia, December 2013
- (2014) E Oehler et al. Eurosurveillance
- The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI
- (2014) Wan-Na Chen et al. FEBS LETTERS
- The multifaceted functions of ribavirin: Antiviral, immunomodulator, or both?
- (2014) Mario U. Mondelli HEPATOLOGY
- A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection
- (2014) Johanna E. Fraser et al. JOURNAL OF INFECTIOUS DISEASES
- Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling
- (2014) J. L. Smith et al. JOURNAL OF VIROLOGY
- The Composition of West Nile Virus Lipid Envelope Unveils a Role of Sphingolipid Metabolism in Flavivirus Biogenesis
- (2014) M. A. Martin-Acebes et al. JOURNAL OF VIROLOGY
- Characterization of the Mode of Action of a Potent Dengue Virus Capsid Inhibitor
- (2014) P. Scaturro et al. JOURNAL OF VIROLOGY
- Effect of nitazoxanide in adults and adolescents with acute uncomplicated influenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial
- (2014) Jason Haffizulla et al. LANCET INFECTIOUS DISEASES
- Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial
- (2014) Jenny G Low et al. LANCET INFECTIOUS DISEASES
- Chloroquine use improves dengue-related symptoms
- (2014) Marcos Carvalho Borges et al. MEMORIAS DO INSTITUTO OSWALDO CRUZ
- Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
- (2014) Travis K. Warren et al. NATURE
- A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
- (2014) Wanwisa Dejnirattisai et al. NATURE IMMUNOLOGY
- Lovastatin Delays Infection and Increases Survival Rates in AG129 Mice Infected with Dengue Virus Serotype 2
- (2014) Marlen Martinez-Gutierrez et al. PLoS One
- A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available
- (2014) Tomohiro Ishikawa et al. VACCINE
- Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model
- (2014) Zixue Shi et al. Virology Journal
- C-Terminal Residue Optimization and Fragment Merging: Discovery of a Potent Peptide-Hybrid Inhibitor of Dengue Protease
- (2014) Mira A. M. Behnam et al. ACS Medicinal Chemistry Letters
- 17D Yellow Fever Virus Vaccine
- (2013) Thomas P. Monath AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 Protease
- (2013) Chi-Chen Yang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase
- (2013) Chelsea M. Byrd et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models
- (2013) Christopher Barton et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Induction of heat-shock protein 70 by prostaglandin A1 inhibits HIV-1 Vif-mediated degradation of APOBEC3G
- (2013) Ryuichi Sugiyama et al. ANTIVIRAL RESEARCH
- An iminosugar with potent inhibition of dengue virus infection in vivo
- (2013) Stuart T. Perry et al. ANTIVIRAL RESEARCH
- 3′,5′Di-O-trityluridine inhibits in vitro flavivirus replication
- (2013) Tine De Burghgraeve et al. ANTIVIRAL RESEARCH
- Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin
- (2013) M.Y.F. Tay et al. ANTIVIRAL RESEARCH
- Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses
- (2013) Jinhong Chang et al. ANTIVIRAL RESEARCH
- Chutes and ladders in hepatitis C nucleoside drug development
- (2013) Steven J. Coats et al. ANTIVIRAL RESEARCH
- A FRET-based assay for the discovery of West Nile Virus NS2B-NS3 protease inhibitors
- (2013) Rebecca N. Adamek et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Breast Milk as a Possible Route of Vertical Transmission of Dengue Virus?
- (2013) Anne Barthel et al. CLINICAL INFECTIOUS DISEASES
- Comparison of the Live Attenuated Yellow Fever Vaccine 17D-204 Strain to Its Virulent Parental Strain Asibi by Deep Sequencing
- (2013) Andrew Beck et al. JOURNAL OF INFECTIOUS DISEASES
- Thiazolidinone–Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture
- (2013) Christoph Nitsche et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of Arenavirus by A3, a Pyrimidine Biosynthesis Inhibitor
- (2013) E. Ortiz-Riano et al. JOURNAL OF VIROLOGY
- Utility of Humanized BLT Mice for Analysis of Dengue Virus Infection and Antiviral Drug Testing
- (2013) N. Frias-Staheli et al. JOURNAL OF VIROLOGY
- The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase
- (2013) M. de Wispelaere et al. JOURNAL OF VIROLOGY
- Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir
- (2013) Y.-L. Chen et al. JOURNAL OF VIROLOGY
- Dengue virus capsid protein interacts specifically with very low-density lipoproteins
- (2013) André F. Faustino et al. Nanomedicine-Nanotechnology Biology and Medicine
- The global distribution and burden of dengue
- (2013) Samir Bhatt et al. NATURE
- Development of a small animal peripheral challenge model of Japanese encephalitis virus using interferon deficient AG129 mice and the SA14-14-2 vaccine virus strain
- (2013) Amanda E. Calvert et al. VACCINE
- TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine
- (2013) Stephanie Jemielity et al. PLoS Pathogens
- Pathogenesis of the Viral Hemorrhagic Fevers
- (2012) Slobodan Paessler et al. Annual Review of Pathology-Mechanisms of Disease
- A Novel Inhibitor of Dengue Virus Replication That Targets the Capsid Protein
- (2012) Chelsea M. Byrd et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A humanized IgG but not IgM antibody is effective in prophylaxis and therapy of yellow fever infection in an AG129/17D-204 peripheral challenge mouse model
- (2012) Brett A. Thibodeaux et al. ANTIVIRAL RESEARCH
- Kyasanur forest disease
- (2012) Michael R. Holbrook ANTIVIRAL RESEARCH
- Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo
- (2012) Hassan Z. A. Ishag et al. ARCHIVES OF VIROLOGY
- The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry
- (2012) Laurent Meertens et al. Cell Host & Microbe
- Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
- (2012) E. Mastrangelo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients
- (2012) Nguyet Minh Nguyen, Chau Nguyen Bich Tran, Lam Khanh Phung, Kien Thi Hue Duong, Huy le Anh Huynh, Jeremy Farrar, Quyen Than Ha Nguyen, Hien Tinh Tran, Chau Van Vinh Nguyen, Laura Merson, Long Truong Hoang, Martin L. Hibberd, Pauline P. K. Aw, Andreas Wilm, Niranjan Nagarajan, Dung Thi Nguyen et al. JOURNAL OF INFECTIOUS DISEASES
- Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection
- (2012) Wenquan Yu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus
- (2012) S. Youn et al. JOURNAL OF VIROLOGY
- hsp70 and a Novel Axis of Type I Interferon-Dependent Antiviral Immunity in the Measles Virus-Infected Brain
- (2012) M. Y. Kim et al. JOURNAL OF VIROLOGY
- Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial
- (2012) Arunee Sabchareon et al. LANCET
- The Chemokine Receptor CCR5, a Therapeutic Target for HIV/AIDS Antagonists, Is Critical for Recovery in a Mouse Model of Japanese Encephalitis
- (2012) Maximilian Larena et al. PLoS One
- A small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain
- (2012) Brett A. Thibodeaux et al. VACCINE
- Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells
- (2012) Rushika Perera et al. PLoS Pathogens
- Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
- (2011) Jan Martin Berke et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Griffithsin Has Antiviral Activity against Hepatitis C Virus
- (2011) Philip Meuleman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- INX-08189, a Phosphoramidate Prodrug of 6-O-Methyl-2′-C-Methyl Guanosine, Is a Potent Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic and Pharmacodynamic Properties
- (2011) John H. Vernachio et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Brain distribution of ribavirin after intranasal administration
- (2011) Gaia Colombo et al. ANTIVIRAL RESEARCH
- Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model
- (2011) Abhay P.S. Rathore et al. ANTIVIRAL RESEARCH
- Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors
- (2011) Suzanne M. Tomlinson et al. ANTIVIRAL RESEARCH
- U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication
- (2011) Mee Kian Poh et al. ANTIVIRAL RESEARCH
- Flaviviral helicase: Insights into the mechanism of action of a motor protein
- (2011) Eloise Mastrangelo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Case report: probable transmission of vaccine strain of yellow fever virus to an infant via breast milk
- (2011) S. Kuhn et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- Mycophenolic Acid Inhibits Replication of Japanese Encephalitis Virus
- (2011) Liba Sebastian et al. CHEMOTHERAPY
- Inhibitor of κB Kinase ϵ (IKKϵ), STAT1, and IFIT2 Proteins Define Novel Innate Immune Effector Pathway against West Nile Virus Infection
- (2011) Olivia Perwitasari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insights into HLA-Restricted T Cell Responses in a Novel Mouse Model of Dengue Virus Infection Point toward New Implications for Vaccine Design
- (2011) Daniela Weiskopf et al. JOURNAL OF IMMUNOLOGY
- A Tick-borne Encephalitis Virus Vaccine Based on the European Prototype Strain Induces Broadly Reactive Cross-neutralizing Antibodies in Humans
- (2011) Klaus K. Orlinger et al. JOURNAL OF INFECTIOUS DISEASES
- Reciprocal Regulation of Human Immunodeficiency Virus-1 Gene Expression and Replication by Heat Shock Proteins 40 and 70
- (2011) Manish Kumar et al. JOURNAL OF MOLECULAR BIOLOGY
- Inhibition of Dengue Virus by Targeting Viral NS4B Protein
- (2011) X. Xie et al. JOURNAL OF VIROLOGY
- Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation
- (2011) C. G. Noble et al. JOURNAL OF VIROLOGY
- Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
- (2011) Sebahattin Cirak et al. LANCET
- Dengue Virus Tropism in Humanized Mice Recapitulates Human Dengue Fever
- (2011) Javier Mota et al. PLoS One
- West Nile Virus Replication Requires Fatty Acid Synthesis but Is Independent on Phosphatidylinositol-4-Phosphate Lipids
- (2011) Miguel A. Martín-Acebes et al. PLoS One
- Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis
- (2011) H.-H. Hoffmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential
- (2011) M. Zasloff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuroinvasive flavivirus infections
- (2011) Gregorius J. Sips et al. REVIEWS IN MEDICAL VIROLOGY
- Flavivirus Cell Entry and Membrane Fusion
- (2011) Jolanda Smit et al. Viruses-Basel
- Evaluation of RepliVAX WN, a Single-Cycle Flavivirus Vaccine, in a Non-Human Primate Model of West Nile Virus Infection
- (2010) Douglas G. Widman et al. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
- Characterization of Dengue Virus Resistance to Brequinar in Cell Culture
- (2010) M. Qing et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Inhibition of Dengue Virus RNA Synthesis by an Adenosine Nucleoside
- (2010) Y.-L. Chen et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay
- (2010) Chi-Chen Yang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2′-ethynyl-7-deaza-adenosine triphosphate
- (2010) Derek R. Latour et al. ANTIVIRAL RESEARCH
- Antibody-dependent enhancement of dengue virus infection in vitro by undiluted sera from monkeys infected with heterotypic dengue virus
- (2010) Mikako Ito et al. ARCHIVES OF VIROLOGY
- Identification of palmatine as an inhibitor of West Nile virus
- (2010) Fan Jia et al. ARCHIVES OF VIROLOGY
- High-Content Assay to Identify Inhibitors of Dengue Virus Infection
- (2010) David Shum et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase
- (2010) Hongping Dong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase
- (2010) Siew Pheng Lim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
- (2010) Michael J. Sofia et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Ubiquitin-Proteasome System Plays an Important Role during Various Stages of the Coronavirus Infection Cycle
- (2010) M. Raaben et al. JOURNAL OF VIROLOGY
- The Proteasome Inhibitor Velcade Enhances rather than Reduces Disease in Mouse Hepatitis Coronavirus-Infected Mice
- (2010) M. Raaben et al. JOURNAL OF VIROLOGY
- Involvement of Ceramide in the Propagation of Japanese Encephalitis Virus
- (2010) H. Tani et al. JOURNAL OF VIROLOGY
- Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis
- (2010) N. S. Heaton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans
- (2010) W. Dejnirattisai et al. SCIENCE
- Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2′-O methyltransferase activity in dengue virus
- (2010) Ka Yan Chung et al. VIROLOGY
- A Randomized Controlled Trial of Chloroquine for the Treatment of Dengue in Vietnamese Adults
- (2010) Vianney Tricou et al. PLoS Neglected Tropical Diseases
- Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses
- (2009) J. Chang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein
- (2009) M. Qing et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A Small-Molecule Dengue Virus Entry Inhibitor
- (2009) Q.-Y. Wang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection
- (2009) D. L. Swenson et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses
- (2009) Thorsten Kampmann et al. ANTIVIRAL RESEARCH
- A small molecule fusion inhibitor of dengue virus
- (2009) Mee Kian Poh et al. ANTIVIRAL RESEARCH
- Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2′-C-methyl-cytidine to its 5′-monophosphate metabolite
- (2009) Nina L. Golitsina et al. ANTIVIRAL RESEARCH
- Pathogenesis of Flavivirus Infections: Using and Abusing the Host Cell
- (2009) Maria-Dolores Fernandez-Garcia et al. Cell Host & Microbe
- Randomized, Controlled Trial of Oral Ribavirin for Japanese Encephalitis in Children in Uttar Pradesh, India
- (2009) Rashmi Kumar et al. CLINICAL INFECTIOUS DISEASES
- Thiazolides: a new class of antiviral drugs
- (2009) Jean-François Rossignol Expert Opinion on Drug Metabolism & Toxicology
- The Anti-Hepatitis C Agent Nitazoxanide Induces Phosphorylation of Eukaryotic Initiation Factor 2α Via Protein Kinase Activated by Double-Stranded RNA Activation
- (2009) Menashe Elazar et al. GASTROENTEROLOGY
- The cyclophilin inhibitor Debio 025 combined with PEG IFNα2a significantly reduces viral load in treatment-naïve hepatitis C patients
- (2009) Robert Flisiak et al. HEPATOLOGY
- CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production
- (2009) Stephen M. Rawlinson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Thiazolides, a New Class of Anti-influenza Molecules Targeting Viral Hemagglutinin at the Post-translational Level
- (2009) Jean François Rossignol et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Proteasome Inhibitor Bortezomib Enhances the Susceptibility to Viral Infection
- (2009) M. Basler et al. JOURNAL OF IMMUNOLOGY
- Clinical evaluation of highly pathogenic tick-borne flavivirus infection in the mouse model
- (2009) Bersabeh Tigabu et al. JOURNAL OF MEDICAL VIROLOGY
- Humanized Mice Show Clinical Signs of Dengue Fever according to Infecting Virus Genotype
- (2009) J. Mota et al. JOURNAL OF VIROLOGY
- Protein Kinase G Phosphorylates Mosquito-Borne Flavivirus NS5
- (2009) D. Bhattacharya et al. JOURNAL OF VIROLOGY
- Neurologic dengue manifestations associated with intrathecal specific immune response
- (2009) M. Puccioni-Sohler et al. NEUROLOGY
- An adenosine nucleoside inhibitor of dengue virus
- (2009) Z. Yin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure
- (2009) M. Issur et al. RNA
- NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease
- (2009) Xun-Cheng Su et al. PLoS Neglected Tropical Diseases
- Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation
- (2009) Marcelo M. Samsa et al. PLoS Pathogens
- The flavivirus polymerase as a target for drug discovery
- (2008) Hélène Malet et al. ANTIVIRAL RESEARCH
- Towards the design of antiviral inhibitors against flaviviruses: The case for the multifunctional NS3 protein from Dengue virus as a target
- (2008) J LESCAR et al. ANTIVIRAL RESEARCH
- Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga
- (2008) Kazuya I.P.J. Hidari et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Minority Quasispecies of Drug‐Resistant HIV‐1 That Lead to Early Therapy Failure in Treatment‐Naive and ‐Adherent Patients
- (2008) Karin J. Metzner et al. CLINICAL INFECTIOUS DISEASES
- Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein
- (2008) Dahai Luo et al. EMBO JOURNAL
- Cell-based assays to identify inhibitors of viral disease
- (2008) Neil Green et al. Expert Opinion on Drug Discovery
- Improved Virologic Response in Chronic Hepatitis C Genotype 4 Treated With Nitazoxanide, Peginterferon, and Ribavirin
- (2008) Jean–François Rossignol et al. GASTROENTEROLOGY
- Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus
- (2008) D. A. Stein et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Analysis of Herpes Zoster Events Among Bortezomib-Treated Patients in the Phase III APEX Study
- (2008) Asher Chanan-Khan et al. JOURNAL OF CLINICAL ONCOLOGY
- Potent Cationic Inhibitors of West Nile Virus NS2B/NS3 Protease With Serum Stability, Cell Permeability and Antiviral Activity
- (2008) Martin J. Stoermer et al. JOURNAL OF MEDICINAL CHEMISTRY
- West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism
- (2008) H. Dong et al. JOURNAL OF VIROLOGY
- Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy
- (2008) Joshua Munger et al. NATURE BIOTECHNOLOGY
- Long-term persistence of tick-borne encephalitis antibodies in adults 5 years after booster vaccination with Encepur® Adults
- (2008) Annelie Plentz et al. VACCINE
- A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor
- (2008) Gang Zou et al. VIROLOGY
- Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
- (2007) Brent E. Korba et al. ANTIVIRAL RESEARCH
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started