Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation

New strategies for targeting matrix metalloproteinases

(2015) Gregg B. Fields   MATRIX BIOLOGY

Design and synthesis of potent hydroxamate inhibitors with increased selectivity within the gelatinase family

(2015) José María Zapico et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Integrated Computational and Experimental Approach to Gaining Selectivity for MMP-2 within the Gelatinase Subfamily

(2014) Benjamin Fabre et al.   CHEMBIOCHEM

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

(2014) Artem Kaplan et al.   NEURON

Unraveling Hidden Regulatory Sites in Structurally Homologous Metalloproteases

(2013) Yael Udi et al.   JOURNAL OF MOLECULAR BIOLOGY

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth

(2012) A. G. Remacle et al.   CANCER RESEARCH

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

(2011) Christian Gege et al.   JOURNAL OF MEDICINAL CHEMISTRY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?

(2009) Netta Sela-Passwell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

(2009) Mark E. Schnute et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Urokinase directly activates matrix metalloproteinases-9: A potential role in glioblastoma invasion

(2008) Yunge Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS