Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery

Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy

(2016) Xiaoding Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

(2016) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

(2016) Yizhou Dong et al.   NANO LETTERS

Systemic delivery of siRNA by hyaluronan-functionalized calcium phosphate nanoparticles for tumor-targeted therapy

(2016) Chong Qiu et al.   Nanoscale

Effective cytoplasmic release of siRNA from liposomal carriers by controlling the electrostatic interaction of siRNA with a charge-invertible peptide, in response to cytoplasmic pH

(2016) Shoko Itakura et al.   Nanoscale

Microfluidics-mediated assembly of functional nanoparticles for cancer-related pharmaceutical applications

(2016) Qiang Feng et al.   Nanoscale

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical and clinical development of siRNA-based therapeutics

(2015) Gulnihal Ozcan et al.   ADVANCED DRUG DELIVERY REVIEWS

Switchable Lipids: Conformational Change for Fast pH-Triggered Cytoplasmic Delivery

(2015) Warren Viricel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

(2015) Emily P. Thi et al.   NATURE

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Clinical experiences with systemically administered siRNA-based therapeutics in cancer

(2015) Jonathan E. Zuckerman et al.   NATURE REVIEWS DRUG DISCOVERY

GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation

(2015) Steve Poirier et al.   Cell Reports

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

(2014) Da Ma   Nanoscale

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Mechanisms of Nanoparticle-Mediated siRNA Transfection by Melittin-Derived Peptides

(2013) Kirk K. Hou et al.   ACS Nano

Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery

(2013) Yunlong Zhang et al.   ADVANCED MATERIALS

pHLIP®-mediated delivery of PEGylated liposomes to cancer cells

(2013) Lan Yao et al.   JOURNAL OF CONTROLLED RELEASE

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Success in amyloidosis trials supports potential of systemic RNAi

(2013) Sarah Crunkhorn   NATURE REVIEWS DRUG DISCOVERY

Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery

(2013) C. A. Alabi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

FRET-Labeled siRNA Probes for Tracking Assembly and Disassembly of siRNA Nanocomplexes

(2012) Christopher A. Alabi et al.   ACS Nano

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gene Silencing Mediated by siRNA-binding Fusion Proteins Is Attenuated by Double-stranded RNA-binding Domain Structure

(2012) James C Geoghegan et al.   Molecular Therapy-Nucleic Acids

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

Before and after Endosomal Escape: Roles of Stimuli-Converting siRNA/Polymer Interactions in Determining Gene Silencing Efficiency

(2011) Young Jik Kwon   ACCOUNTS OF CHEMICAL RESEARCH

Molecular Tweezers: Concepts and Applications

(2011) Jeanne Leblond et al.   CHEMPHYSCHEM

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

(2008) E Wisse et al.   GENE THERAPY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA