Artesunate Activates the Intrinsic Apoptosis of HCT116 Cells through the Suppression of Fatty Acid Synthesis and the NF-κB Pathway

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

(2017) Jigang Wang et al.   ACS Central Science

Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity

(2016) Chong-Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Target identification of natural and traditional medicines with quantitative chemical proteomics approaches

(2016) Jigang Wang et al.   PHARMACOLOGY & THERAPEUTICS

Target identification with quantitative activity based protein profiling (ABPP)

(2016) Xiao Chen et al.   PROTEOMICS

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line

(2016) Jigang Wang et al.   Scientific Reports

Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress

(2015) Marjorie Fullerton et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Cleaved PARP-1, an Apoptotic Marker, can be Detected in Ram Spermatozoa

(2015) A Casao et al.   REPRODUCTION IN DOMESTIC ANIMALS

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP)

(2015) Jigang Wang et al.   Scientific Reports

Artesunate Induces Cell Death in Human Cancer Cells via Enhancing Lysosomal Function and Lysosomal Degradation of Ferritin

(2014) Nai-Di Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Quantitative Chemical Proteomics Approach to Profile the Specific Cellular Targets of Andrographolide, a Promising Anticancer Agent That Suppresses Tumor Metastasis

(2014) Jigang Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

The Synergistic Anticancer Effect of Artesunate Combined with Allicin in Osteosarcoma Cell Line in Vitro and in Vivo

(2013) Wei Jiang et al.   Asian Pacific Journal of Cancer Prevention

Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds

(2013) Javier Vaquero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells

(2012) Zhongyong Jiang et al.   ANTI-CANCER DRUGS

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

(2012) Muthu K. Shanmugam et al.   CANCER LETTERS

Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

(2011) Mohd Imran Khan et al.   BIOMATERIALS

Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase

(2011) Yanyan Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

(2011) Maria P. Crespo-Ortiz et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids

(2011) Jiřina Hofmanová et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells

(2010) Colm Morrissey et al.   ANTI-CANCER DRUGS

Antioxidant, Antiproliferative, and Pro-apoptotic Capacities of Pentacyclic Triterpenes Found in the Skin of Olives on MCF-7 Human Breast Cancer Cells and Their Effects on DNA Damage

(2010) Yosra Allouche et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

(2010) Amy E. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

(2009) Martin Michaelis et al.   BIOCHEMICAL PHARMACOLOGY

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression

(2009) C Riganti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

(2009) Ji-Hui Du et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Anticancer activities of artemisinin and its bioactive derivatives

(2009) Gary L. Firestone et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Involvement of VDAC, Bax and Ceramides in the Efflux of AIF from Mitochondria during Curcumin-Induced Apoptosis

(2009) Alwin Scharstuhl et al.   PLoS One

In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway

(2008) Ruifen Zhang et al.   APOPTOSIS

Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells

(2008) M. Emília Juan et al.   BRITISH JOURNAL OF NUTRITION

Identification of PP2A as a crucial regulator of the NF-κB feedback loop: its inhibition by UVB turns NF-κB into a pro-apoptotic factor

(2008) S Barisic et al.   CELL DEATH AND DIFFERENTIATION

Nuclear Factor-κB Activation: From Bench to Bedside

(2008) Gautam Sethi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L

(2008) S. Tamai et al.   JOURNAL OF CELL SCIENCE

Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation

(2007) Ikuhiko Nakase et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS