Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

Synthesis of 10β-Substituted Triazolyl Artemisinins and Their Growth Inhibitory Activity against Various Cancer Cells

(2011) Seok-Joon Lee   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway

(2011) Shuang-Jia Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

2011: the immune hallmarks of cancer

(2011) Federica Cavallo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis

(2011) Christopher M. Cabello et al.   INVESTIGATIONAL NEW DRUGS

Down-regulation of BMI-1 cooperates with artemisinin on growth inhibition of nasopharyngeal carcinoma cells

(2011) Jing Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Artesunate inhibits growth and induces apoptosis in human osteosarcoma HOS cell line in vitro and in vivo

(2011) Qiang Xu et al.   Journal of Zhejiang University-SCIENCE B

Anti-tumor effects of dihydroartemisinin on human osteosarcoma

(2011) Ye Ji et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Development of Resistance towards Artesunate in MDA-MB-231 Human Breast Cancer Cells

(2011) Beatrice Bachmeier et al.   PLoS One

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme as Trigger and Target for Trioxane-Containing Antimalarial Drugs†

(2010) Bernard Meunier et al.   ACCOUNTS OF CHEMICAL RESEARCH

Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells

(2010) Colm Morrissey et al.   ANTI-CANCER DRUGS

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells

(2010) Jin-Jian Lu et al.   BIOCHEMICAL PHARMACOLOGY

Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCα/Raf/MAPKs and NF-κB/AP-1-dependent mechanisms

(2010) Yong Pil Hwang et al.   BIOCHEMICAL PHARMACOLOGY

In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents

(2010) Andrew M. Gravett et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Dihydroartemisinin inactivates NF-κB and potentiates the anti-tumor effect of gemcitabine on pancreatic cancer both in vitro and in vivo

(2010) Shuang-Jia Wang et al.   CANCER LETTERS

Factors determining sensitivity or resistance of tumor cell lines towards artesunate

(2010) Serkan Sertel et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Toxicity of the antimalarial artemisinin and its dervatives

(2010) Thomas Efferth et al.   CRITICAL REVIEWS IN TOXICOLOGY

Chemosensitization of Prostate Cancer by Modulating Bcl-2 Family Proteins

(2010) David Karnak et al.   CURRENT DRUG TARGETS

First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases

(2010) Suhail Ahmed Kabeer Rasheed et al.   INTERNATIONAL JOURNAL OF CANCER

The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies

(2010) Wai M. Liu et al.   INTERNATIONAL JOURNAL OF CANCER

The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

(2010) Jin-Jian Lu et al.   INVESTIGATIONAL NEW DRUGS

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

(2010) Amy E. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell analysis of dihydroartemisinin–induced apoptosis through reactive oxygen species–mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques

(2010) Ying-Ying Lu et al.   JOURNAL OF BIOMEDICAL OPTICS

Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties

(2010) Shahid Soomro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells

(2010) Cindy Horwedel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

(2010) R. Handrick et al.   MOLECULAR CANCER THERAPEUTICS

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Subcellular Localization of a Fluorescent Artemisinin Derivative to Endoplasmic Reticulum

(2010) Yungen Liu et al.   ORGANIC LETTERS

Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells

(2010) Tan Weifeng et al.   PHYTOMEDICINE

The Role of Traditional Chinese Herbal Medicines in Cancer Therapy – from TCM Theory to Mechanistic Insights

(2010) W. Hsiao et al.   PLANTA MEDICA

Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo

(2009) Hua Chen et al.   ANTI-CANCER DRUGS

Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells

(2009) Mahmoud Youns et al.   BIOCHEMICAL PHARMACOLOGY

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

(2009) Martin Michaelis et al.   BIOCHEMICAL PHARMACOLOGY

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression

(2009) C Riganti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dihydroartemisinin improves the efficiency of chemotherapeutics in lung carcinomas in vivo and inhibits murine Lewis lung carcinoma cell line growth in vitro

(2009) Hui-Jun Zhou et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

(2009) Ji-Hui Du et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Anticancer activities of artemisinin and its bioactive derivatives

(2009) Gary L. Firestone et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Inhibitive Effect of Artemether on Tumor Growth and Angiogenesis in the Rat C6 Orthotopic Brain Gliomas Model

(2009) Zhi-ping Wu et al.   INTEGRATIVE CANCER THERAPIES

Dihydroartemisinin can inhibit calmodulin, calmodulin-dependent phosphodiesterase activity and stimulate cellular immune responses

(2009) Shokoofe Noori et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

(2009) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Effect of artesunate on inhibiting proliferation and inducing apoptosis of SP2/0 myeloma cells through affecting NFκB p65

(2009) Shihui Li et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preparation of Bicyclic 1,2,4-Trioxanes from γ,δ-Unsaturated Ketones

(2009) Armando P. Ramirez et al.   ORGANIC LETTERS

Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target

(2009) Shiming Zhang et al.   PLoS One

Relationship between Antimalarial Activity and Heme Alkylation for Spiro- and Dispiro-1,2,4-Trioxolane Antimalarials

(2008) D. J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

(2008) J. Hou et al.   CLINICAL CANCER RESEARCH

Differential sensitivity of colorectal cancer cell lines to artesunate is associated with expression of beta-catenin and E-cadherin

(2008) Lin-Na Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Artemisinin reduces human melanoma cell migration by down-regulating αVβ3 integrin and reducing metalloproteinase 2 production

(2008) Elisabetta Buommino et al.   INVESTIGATIONAL NEW DRUGS

Indole-3-carbinol Inhibits Sp1-Induced Matrix Metalloproteinase-2 Expression To Attenuate Migration and Invasion of Breast Cancer Cells

(2008) Wen-Chun Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression

(2008) Jamin A. Willoughby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy

(2008) Tao Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials(1)

(2008) Igor Opsenica et al.   JOURNAL OF MEDICINAL CHEMISTRY

SPC3042: a proapoptotic survivin inhibitor

(2008) J. B. Hansen et al.   MOLECULAR CANCER THERAPEUTICS

Artemisinin Inhibits Tumor Lymphangiogenesis by Suppression of Vascular Endothelial Growth Factor C

(2008) Jun Wang et al.   PHARMACOLOGY

Dihydroartemisinin Potentiates the Cytotoxic Effect of Temozolomide in Rat C6 Glioma Cells

(2008) Xiao-Jia Huang et al.   PHARMACOLOGY

Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugation

(2007) Ikuhiko Nakase et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS