The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species

(2010) Jin-Jian Lu et al.   CANCER BIOLOGY & THERAPY

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

(2010) R. Handrick et al.   MOLECULAR CANCER THERAPEUTICS

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Artemisinin resistance on the Thai–Cambodian border

(2009) Olaf Müller et al.   LANCET

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Heme Mediates Cytotoxicity from Artemisinin and Serves as a General Anti-Proliferation Target

(2009) Shiming Zhang et al.   PLoS One

Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

(2009) Robert L. Clark   REPRODUCTIVE TOXICOLOGY

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis

(2009) Amy E. Mercer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ATP depletion alters the mode of cell death induced by benzyl isothiocyanate

(2008) Noriyuki Miyoshi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin

(2008) Shiming Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Artesunate Derived from Traditional Chinese Medicine Induces DNA Damage and Repair

(2008) P. C.H. Li et al.   CANCER RESEARCH

Resistance of mtDNA-depleted cells to apoptosis

(2008) Roberta Ferraresi et al.   CYTOMETRY PART A

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX)

(2008) Monica Longo et al.   REPRODUCTIVE TOXICOLOGY