Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Evidence that Non-Fibrillar Tau Causes Pathology Linked to Neurodegeneration and Behavioral Impairments

(2017) Kurt R. Brunden et al.   JOURNAL OF ALZHEIMERS DISEASE

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases

(2016) Irene Sambri et al.   EMBO Molecular Medicine

A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer’s Disease

(2016) Andres M. Lozano et al.   JOURNAL OF ALZHEIMERS DISEASE

Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial

(2016) Francisco A. Ponce et al.   JOURNAL OF NEUROSURGERY

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Deep Brain Stimulation Influences Brain Structure in Alzheimer's Disease

(2015) Tejas Sankar et al.   Brain Stimulation

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease

(2015) Anita Stargardt et al.   NEUROBIOLOGY OF AGING

Eating Locally: Microautophagy and Protein Turnover at the Synapse

(2015) Peter S. McPherson   NEURON

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy

(2015) Valerie Uytterhoeven et al.   NEURON

Synaptic activity and Alzheimer's disease: a critical update

(2015) Davide Tampellini   Frontiers in Neuroscience

Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons

(2014) A.E. Ramírez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

(2014) M. L. Frandemiche et al.   JOURNAL OF NEUROSCIENCE

Neural compensation in older people with brain amyloid-β deposition

(2014) Jeremy A Elman et al.   NATURE NEUROSCIENCE

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

(2014) Susana Revilla et al.   NEUROPHARMACOLOGY

Role of Endosomes and Lysosomes in Human Disease

(2014) F. R. Maxfield   Cold Spring Harbor Perspectives in Biology

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer Disease

(2012) Gwenn S. Smith et al.   ARCHIVES OF NEUROLOGY

Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   Autophagy

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

The divergence–convergence model of acquired neuroprotection

(2012) Carlos Bas-Orth et al.   MECHANISMS OF DEVELOPMENT

p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress

(2012) Huabo Su et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Impaired  -Amyloid Secretion in Alzheimer's Disease Pathogenesis

(2011) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

(2011) S. S. D. Stone et al.   JOURNAL OF NEUROSCIENCE

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease

(2010) Adrian W. Laxton et al.   ANNALS OF NEUROLOGY

(Re-)activation of neurons in aging and dementia: Lessons from the hypothalamus

(2010) Dick F. Swaab et al.   EXPERIMENTAL GERONTOLOGY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Synaptic Modulation on  -Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

(2010) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Synapse loss in dementias

(2010) Ryan Clare et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline

(2010) J. L. O'Brien et al.   NEUROLOGY

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Synaptic Activity Reduces Intraneuronal A , Promotes APP Transport to Synapses, and Protects against A -Related Synaptic Alterations

(2009) D. Tampellini et al.   JOURNAL OF NEUROSCIENCE

Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia

(2009) Reisa A. Sperling et al.   NEURON

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY