Soluble Amyloid Precursor Protein Alpha Interacts with alpha3-Na, K-ATPAse to Induce Axonal Outgrowth but Not Neuroprotection: Evidence for Distinct Mechanisms Underlying these Properties

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A

(2014) Stéphanie Chasseigneaux et al.   BMC NEUROSCIENCE

Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I2PP2A) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau

(2014) Mohammad Arif et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulating Set- 's Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration

(2014) E. F. Trakhtenberg et al.   JOURNAL OF NEUROSCIENCE

The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

(2014) N Milosch et al.   Cell Death & Disease

Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsα expression

(2014) Sascha W Weyer et al.   Acta Neuropathologica Communications

Soluble amyloid-  precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

(2013) C. Reinhard et al.   JOURNAL OF CELL SCIENCE

Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease

(2013) Guang Yu et al.   NEUROBIOLOGY OF AGING

Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation

(2013) Michael P. Demars et al.   NEUROBIOLOGY OF AGING

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients

(2013) Patricia Facchinetti et al.   NEUROBIOLOGY OF AGING

Soluble β-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth

(2013) Noriko Hasebe et al.   PLoS One

Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration

(2012) B. Daniel Lam et al.   FEBS LETTERS

A Specific and Essential Role for Na,K-ATPase α3 in Neurons Co-expressing α1 and α3

(2012) Guillaume Azarias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the effects of treatment with sAPPα on functional and histological outcome following controlled cortical impact injury in mice

(2012) Frances Corrigan et al.   NEUROSCIENCE LETTERS

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor Protein α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway

(2011) Stéphanie Chasseigneaux et al.   PLoS One

Protein Phosphatase 2A Interacts with the Na+,K+-ATPase and Modulates Its Trafficking by Inhibition of Its Association with Arrestin

(2011) Toru Kimura et al.   PLoS One

sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

(2010) Ekaterini Copanaki et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAT1 induces cell death signal and SET mislocalization into the cytoplasm by increasing APP/APLP2 at the cell surface

(2009) Stéphanie Briand et al.   NEUROBIOLOGY OF AGING

Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway

(2008) Nidhi Gakhar-Koppole et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-Protocadherin and TAF1 Regulate Retinal Axon Initiation and Elongation In Vivo

(2008) M. Piper et al.   JOURNAL OF NEUROSCIENCE

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE