Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Novel G S-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain

(2012) C. Deyts et al.   JOURNAL OF NEUROSCIENCE

Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

(2012) Jill S. Wentzell et al.   NEUROBIOLOGY OF DISEASE

The physiological functions of the β-amyloid precursor protein APP

(2012) Ulrike C. Müller et al.   EXPERIMENTAL BRAIN RESEARCH

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

(2011) Frances Corrigan et al.   BRAIN RESEARCH

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Age-dependent Accumulation of Soluble Amyloid β (Aβ) Oligomers Reverses the Neuroprotective Effect of Soluble Amyloid Precursor Protein-α (sAPPα) by Modulating Phosphatidylinositol 3-Kinase (PI3K)/Akt-GSK-3β Pathway in Alzheimer Mouse Model

(2011) Sebastian Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

(2011) Donat Kögel et al.   NEUROBIOLOGY OF AGING

Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase

(2011) Sebastian Hogl et al.   PLoS One

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging

(2011) Donat Kögel et al.   EXPERIMENTAL BRAIN RESEARCH

Structural aspects and physiological consequences of APP/APLP trans-dimerization

(2011) Frederik Baumkötter et al.   EXPERIMENTAL BRAIN RESEARCH

Regulation of alpha-secretase ADAM10 expression and activity

(2011) Kristina Endres et al.   EXPERIMENTAL BRAIN RESEARCH

Functions of the APP gene family in the nervous system: insights from mouse models

(2011) Dorothee Aydin et al.   EXPERIMENTAL BRAIN RESEARCH

Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing

(2010) Gunter P. Eckert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

(2010) Ekaterini Copanaki et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors

(2010) Brigitte Anliker et al.   NATURE METHODS

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

(2008) Thorsten Müller et al.   PROGRESS IN NEUROBIOLOGY