Article
Psychiatry
Xiaoli Li, Ping Zhou, Qiu Li, Bin Peng, Yupeng Cun, Ying Dai, Hua Wei, Xiao Liu, Yang Yu, Zhiyang Jiang, Qiongli Fan, Yuping Zhang, Ting Yang, Jie Chen, Qian Cheng, Tingyu Li, Li Chen
Summary: This study investigated plasma biomarkers in individuals with regressive autism spectrum disorder (RA) and found significantly elevated levels of sAPPtotal and sAPP alpha, which may serve as potential biomarkers for early identification of autism regression.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jean-Marie Billard, Thomas Freret
Summary: This study found that adding sAPP alpha significantly increased the activation of NMDAR in aged mice and rescued the deficit of long-term potentiation in these mice. The improvement of NMDAR in adult mice was also significantly increased with a higher concentration of sAPP alpha, but this effect was reduced in transgenic mice lacking the synthesizing enzyme serine racemase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Heather M. Wilkins, Benjamin R. Troutwine, Blaise W. Menta, Sharon J. Manley, Taylor A. Strope, Colton R. Lysaker, Russell H. Swerdlow
Summary: This study reveals that mitochondrial function affects the localization of amyloid-beta protein precursor and its secretion. Enhanced mitochondrial activity promotes amyloid-beta secretion, while depressed mitochondrial activity reduces amyloid-beta secretion. These findings provide insights into the pathogenesis of Alzheimer's disease and the potential use of amyloid-beta secretion as a biomarker of mitochondrial function.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biology
Pascal Dominic Rem, Vita Sereikaite, Diego Fernandez-Fernandez, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salome Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Stromgaard, Bernhard Bettler
Summary: Amyloid-beta precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. A 17 amino acid peptide (APP17) derived from APP binds to the extracellular sushi domain 1 (SD1) of GABA(B) receptors (GBRs). However, APP17 does not influence GBR activity in heterologous cells, indicating that sAPP exerts its neuronal effects through receptors other than GBRs.
Review
Biochemistry & Molecular Biology
Vladimir Rudajev, Jiri Novotny
Summary: This article discusses the relationship between cholesterol and the development of Alzheimer's disease, as well as the influence of cholesterol on the production of amyloid beta (Aβ).
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Edward Chau, Jin Ryoun Kim
Summary: This study investigated the interactions between Aβ42 and αS in different conformations. It was found that αS monomers and oligomers promoted the oligomerization and stabilization of soluble Aβ42, while αS fibrils hindered the aggregation of Aβ42. These interactions may be achieved through direct binding or co-assembly, and different parts of Aβ42 mediated the interactions with αS.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Jowita Nowakowska-Golacka, Justyna Czapiewska, Hanna Sominka, Natalia Sowa-Rogozinska, Monika Slominska-Wojewodzka
Summary: EDEM1 is an important regulatory factor involved in APP metabolism, as it recognizes misfolded APP proteins and directs them to cytosol for degradation, leading to decreased secretion of Aβ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jacob W. Astroski, Leonora K. Akporyoe, Elliot J. Androphy, Sara K. Custer
Summary: Understanding the genetics of families with histories of AD is crucial in understanding the cellular processes involved in Alzheimer's disease. Mutations in the COPI complex have been found in these families, and recent studies suggest that components of the COPI complex can affect the metabolism of pathogenic AD proteins. Depletion of the COPI subunit a-COP has been shown to alter the processing of both APP and Tau, potentially leading to pathogenic changes associated with AD.
NEUROBIOLOGY OF AGING
(2021)
Review
Biochemistry & Molecular Biology
Jin Ryoun Kim
Summary: This mini review summarizes the findings on the interactions between A beta and alpha S, which enhance oligomerization via co-assembly. It aims to provide a better understanding of the complex biology behind AD and PD and common pathological mechanisms among the major neurodegenerative diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Geriatrics & Gerontology
Kenji Yamamoto, Ryo Yamamoto, Nobuo Kato
Summary: In this study, it was found that specific antibodies can recover the activity of BK channels suppressed by Aβ oligomers in neurons of Alzheimer's disease model mice, suggesting an important role of APP in this process.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Alexandra A. Sandberg, Evan Manning, Heather M. Wilkins, Randall Mazzarino, Taylor Minckley, Russell H. Swerdlow, David Patterson, Yan Qin, Daniel A. Linseman
Summary: In this study, the potential of mitochondrial-targeted AICD to induce neuronal apoptosis and its mechanism of neurotoxicity were examined. The results showed that only when AICD was targeted to the mitochondria, significant neuronal apoptosis was induced. Furthermore, AICD induced apoptosis via a mechanism that is distinct from that of A beta.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Endocrinology & Metabolism
Yanjun Guo, Qinqiu Wang, Shenghui Chen, Chengfu Xu
Summary: This article summarizes the regulatory effects of APP and its cleavage peptides on metabolism in the central nervous system and peripheral tissues, indicating that peptides generated by non-amyloidogenic processing can have positive effects on metabolism, while those produced by amyloidogenic processing may have negative impacts. Abnormal expression of APP is associated with metabolic diseases (such as diabetes, obesity, etc.) and cancer.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Cell Biology
Grant Pfundstein, Alexander G. Nikonenko, Vladimir Sytnyk
Summary: This review examines the interactions of cell adhesion molecules with APP and Aβ, and analyzes the critical role these proteins play in regulating APP metabolism and physiological function, as well as Aβ toxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Xi-Jun Song, He-Yan Zhou, Yu-Ying Sun, Han-Chang Huang
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of senile plaques, Aβ peptide, is derived from AβPP through cleaving by enzymes. Post-translational modifications like phosphorylation and glycosylation of AβPP may affect its trafficking and cleavage.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Mei Feng, Yi Song, Serena H. Chen, Yuanzhao Zhang, Ruhong Zhou
Summary: A recent study revealed that the extension domain of sAPP can bind to the sushi 1 domain of GABA(B)R1a and modulate its synaptic transmission, providing a structural foundation for future drug design. Molecular dynamics simulations and free energy perturbation calculations identified key residues and mutations affecting the binding between sAPP and sushi 1 domain, potentially leading to enhanced GABA(B)R1a modulation. These findings offer new insights into the interactions and may pave the way for the development of GABA(B)R1a-specific therapeutics.
Article
Neurosciences
Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Lea Huguet, Lucie Gorisse-Hussonnois, Stephanie Chasseigneaux, Bernadette Allinquant
Article
Neurosciences
Emilie Dorard, Stephanie Chasseigneaux, Lucie Gorisse-Hussonnois, Cedric Broussard, Thierry Pillot, Bernadette Allinquant
MOLECULAR NEUROBIOLOGY
(2018)
Article
Cell Biology
Anne-Cecile Boulay, Bruno Saubamea, Nicolas Adam, Stephanie Chasseigneaux, Noemie Mazare, Alice Gilbert, Mathieu Bahin, Leila Bastianelli, Corinne Blugeon, Sandrine Perrin, Juliette Pouch, Bertrand Ducos, Stephane Le Crom, Auguste Genovesio, Fabrice Chretien, Xavier Decleves, Jean-Louis Laplanche, Martine Cohen-Salmon
Article
Neurosciences
Christiane Rose, Katell Peoc'h, Stephanie Chasseigneaux, Claire Paquet, Julien Dumurgier, Fanchon Bourasset, Frederic Calon, Jean-Louis Laplanche, Jacques Hugon, Bernadette Allinquant
Article
Neurosciences
Stephanie Chasseigneaux, Christine Clamagirand, Lea Huguet, Lucie Gorisse-Hussonnois, Christiane Rose, Bernadette Allinquant
Article
Neurosciences
Tuan Minh Do, Beatrice Bedussi, Stephanie Chasseigneaux, Agnes Dodacki, Cedric Yapo, Helene Chacun, Jean-Michel Scherrmann, Robert Farinotti, Fanchon Bourasset
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Review
Biochemistry & Molecular Biology
Stephanie Chasseigneaux, Bernadette Allinquant
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Multidisciplinary Sciences
Agnes Dodacki, Matthew Wortman, Bruno Saubamea, Stephanie Chasseigneaux, Sophie Nicolic, Nathalie Prince, Murielle Lochus, Anne-Laure Raveu, Xavier Decleves, Jean-Michel Scherrmann, Shailendra B. Patel, Fanchon Bourasset
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Stephanie Chasseigneaux, Yasmine Moraca, Veronique Cochois-Guegan, Anne-Cecile Boulay, Alice Gilbert, Stephane Le Crom, Corinne Blugeon, Cyril Firmo, Salvatore Cisternino, Jean-Louis Laplanche, Emmanuel Curis, Xavier Decleves, Bruno Saubamea
SCIENTIFIC REPORTS
(2018)
Article
Clinical Neurology
Luisa Alessandra Atehortua-Martinez, Cyriaque Masniere, Patrizia Campolongo, Stephanie Chasseigneaux, Jacques Callebert, Clemens Zwergel, Antonello Mai, Jean-Louis Laplanche, Huixiong Chen, Melanie Etheve-Quelquejeu, Bruno Megarbane, Nadia Benturquia
JOURNAL OF PSYCHOPHARMACOLOGY
(2019)
Article
Medicine, Research & Experimental
Huilong Luo, Elisa Rossi, Bruno Saubamea, Stephanie Chasseigneaux, Veronique Cochois, Nina Choublier, Maria Smirnova, Fabienne Glacial, Nicolas Perriere, Sandrine Bourdoulous, David M. Smadja, Marie-Claude Menet, Pierre-Olivier Couraud, Salvatore Cisternino, Xavier Decleves
MOLECULAR PHARMACEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Lucie Gorisse-Hussonnois, Florian Rebeillard, Lea Huguet, David Geny, Vincent Contremoulins, Fabian Corlier, Marie-Claude Potier, Stephanie Chasseigneaux, Michele Darmon, Bernadette Allinquant
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Neurosciences
Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubamea, Stephanie Chasseigneaux, Veronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnes Dodacki, Salvatore Cisternino, Xavier Decleves, Fanchon Bourasset
Summary: The inducible p25 overexpression mouse model showed no significant alterations in brain vascular surface area and BBB physical integrity, but a 14% decrease in cerebrovascular volume in 6 weeks ON mice, possibly due to a 27% increase in collagen IV in brain capillaries. Additionally, a 17% reduction in D-glucose brain uptake was observed in 6 weeks ON p25 mice, indicating impaired BBB transport function.
Article
Cell Biology
Huilong Luo, Bruno Saubamea, Stephanie Chasseigneaux, Veronique Cochois, Maria Smirnova, Fabienne Glacial, Nicolas Perriere, Catarina Chaves, Salvatore Cisternino, Xavier Decleves
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Shannon Dallas, Laurent Salphati, David Gomez-Zepeda, Thomas Wanek, Liangfu Chen, Xiaoyan Chu, Jeevan Kunta, Mario Mezler, Marie-Claude Menet, Stephanie Chasseigneaux, Xavier Decleves, Oliver Langer, Esaie Pierre, Karen DiLoreto, Carolin Hoft, Loic Laplanche, Jodie Pang, Tony Pereira, Clara Andonian, Damir Simic, Anja Rode, Jocelyn Yabut, Xiaolin Zhang, Nico Scheer
MOLECULAR PHARMACOLOGY
(2016)