TDP-43 and Cytoskeletal Proteins in ALS

Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP

(2016) Pritha Majumder et al.   ACTA NEUROPATHOLOGICA

TBPH/TDP-43 modulates translation of Drosophila futsch mRNA through an UG-rich sequence within its 5′UTR

(2016) Maurizio Romano et al.   BRAIN RESEARCH

Microtubules in health and degenerative disease of the nervous system

(2016) Andrew J. Matamoros et al.   BRAIN RESEARCH BULLETIN

Pathogenesis of amyotrophic lateral sclerosis

(2016) Sarah Morgan et al.   BRITISH MEDICAL BULLETIN

The emerging role of the tubulin code: From the tubulin molecule to neuronal function and disease

(2016) Soumyananda Chakraborti et al.   Cytoskeleton

Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function

(2016) Sandro Orrù et al.   HUMAN MOLECULAR GENETICS

Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation

(2016) Yoshinori Tanaka et al.   HUMAN MOLECULAR GENETICS

Axonal transport defects are a common phenotype inDrosophilamodels of ALS

(2016) Katie R. Baldwin et al.   HUMAN MOLECULAR GENETICS

Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins

(2016) Antonia Ratti et al.   JOURNAL OF NEUROCHEMISTRY

Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy

(2016) K. J. Spiller et al.   JOURNAL OF NEUROSCIENCE

Phosphorylated neurofilament heavy chain levels in paired plasma and CSF of amyotrophic lateral sclerosis

(2016) Siyuan Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

Multicenter validation of CSF neurofilaments as diagnostic biomarkers for ALS

(2016) Patrick Oeckl et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

(2016) Henrik Zetterberg et al.   JAMA Neurology

Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis

(2015) Patrick Weydt et al.   ANNALS OF NEUROLOGY

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

Time to generalisation as a predictor of prognosis in amyotrophic lateral sclerosis: Table 1

(2015) Rosanna Tortelli et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients

(2015) Petra Steinacker et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse

(2015) Yao Liu et al.   NEUROBIOLOGY OF AGING

Shared Molecular Mechanisms in Alzheimer's Disease and Amyotrophic Lateral Sclerosis: Neurofilament-Dependent Transport of sAPP, FUS, TDP-43 and SOD1, with Endoplasmic Reticulum-Like Tubules

(2015) Virgil Muresan et al.   Neurodegenerative Diseases

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis

(2015) C.-H. Lu et al.   NEUROLOGY

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS

(2015) L. Comley et al.   NEUROSCIENCE

An acetylation switch controls TDP-43 function and aggregation propensity

(2015) Todd J. Cohen et al.   Nature Communications

Kinesin-5 is a microtubule polymerase

(2015) Yalei Chen et al.   Nature Communications

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

(2014) Johannes Brettschneider et al.   ACTA NEUROPATHOLOGICA

“Structural characterization of the minimal segment of TDP-43 competent for aggregation”

(2014) Miguel Mompeán et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cerebrospinal fluid neurofilament light chain levels: marker of progression to generalized amyotrophic lateral sclerosis

(2014) R. Tortelli et al.   EUROPEAN JOURNAL OF NEUROLOGY

TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain

(2014) Mauricio Budini et al.   HUMAN MOLECULAR GENETICS

Evolutionarily Conserved Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A/B Proteins Functionally Interact with Human andDrosophilaTAR DNA-binding Protein 43 (TDP-43)

(2014) Maurizio Romano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

(2014) A. N. Coyne et al.   JOURNAL OF NEUROSCIENCE

Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo

(2014) Vineeta Bhasker Tripathi et al.   NEUROBIOLOGY OF DISEASE

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

(2014) Nael H. Alami et al.   NEURON

Exome-wide Rare Variant Analysis Identifies TUBA4A Mutations Associated with Familial ALS

(2014) Bradley N. Smith et al.   NEURON

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients

(2014) Yu-Sheng Fang et al.   Nature Communications

Review on intermediate filaments of the nervous system and their pathological alterations

(2013) Claire Lépinoux-Chambaud et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates

(2013) Yi-Ting Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubules in neurons as information carriers

(2013) Erik W. Dent et al.   JOURNAL OF NEUROCHEMISTRY

Immune reactivity to neurofilament proteins in the clinical staging of amyotrophic lateral sclerosis

(2013) F. Puentes et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

(2013) Peter J Lukavsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila

(2013) Lies Vanden Broeck et al.   Cell Reports

Neurofilaments at a glance

(2012) A. Yuan et al.   JOURNAL OF CELL SCIENCE

Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

(2012) M. Takahashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulated protein aggregation: stress granules and neurodegeneration

(2012) Benjamin Wolozin   Molecular Neurodegeneration

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Move in for the kill: motile microtubule regulators

(2012) Xiaolei Su et al.   TRENDS IN CELL BIOLOGY

pNfH is a promising biomarker for ALS

(2012) Jeban Ganesalingam et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments

(2011) Vivek Swarup et al.   BRAIN

Microtubules and mitogen-activated protein kinase signalling

(2011) George Komis et al.   CURRENT OPINION IN PLANT BIOLOGY

TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1

(2011) Karli K. McDonald et al.   HUMAN MOLECULAR GENETICS

A “Two-hit” Hypothesis for Inclusion Formation by Carboxyl-terminal Fragments of TDP-43 Protein Linked to RNA Depletion and Impaired Microtubule-dependent Transport

(2011) G. Scott Pesiridis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS

(2011) Jeban Ganesalingam et al.   JOURNAL OF NEUROCHEMISTRY

Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis

(2011) Yuji Mizuno et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Dendritic Spine Plasticity: New Regulatory Roles of Dynamic Microtubules

(2011) Casper C. Hoogenraad et al.   NEUROSCIENTIST

The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism

(2011) Chunxing Yang et al.   PLoS One

TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization

(2011) Vinay K. Godena et al.   PLoS One

Glycogen synthase kinase 3 in the world of cell migration

(2010) Tong Sun et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Ubiquilin Modifies TDP-43 Toxicity in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)

(2010) Keith A. Hanson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel peripherin gene (PRPH) mutation identified in one sporadic amyotrophic lateral sclerosis patient

(2010) Lucia Corrado et al.   NEUROBIOLOGY OF AGING

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

A Drosophila model for TDP-43 proteinopathy

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation

(2010) Emanuele Buratti et al.   RNA Biology

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

(2009) Kathryn Volkening et al.   BRAIN RESEARCH

Microtubule-severing enzymes

(2009) Antonina Roll-Mecak et al.   CURRENT OPINION IN CELL BIOLOGY

TDP-43 is recruited to stress granules in conditions of oxidative insult

(2009) Claudia Colombrita et al.   JOURNAL OF NEUROCHEMISTRY

CSF neurofilament protein analysis in the differential diagnosis of ALS

(2009) Thierry S. Reijn et al.   JOURNAL OF NEUROLOGY

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

(2009) A. D'Ambrogio et al.   NUCLEIC ACIDS RESEARCH

Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

(2008) Lionel M. Igaz et al.   AMERICAN JOURNAL OF PATHOLOGY

An Aggregate-Inducing Peripherin Isoform Generated through Intron Retention Is Upregulated in Amyotrophic Lateral Sclerosis and Associated with Disease Pathology

(2008) S. Xiao et al.   JOURNAL OF NEUROSCIENCE

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

(2008) Vivianna M Van Deerlin et al.   LANCET NEUROLOGY