期刊
NEUROSCIENTIST
卷 16, 期 6, 页码 650-661出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858410386357
关键词
synaptic plasticity; dendritic spines; cytoskeleton; microtubule; actin; EB family proteins
资金
- Netherlands Organization for Scientific Research (NWO)
- Netherlands Organization for Health Research and Development
- European Science Foundation
- Human Frontier Science Program Career Development
- Netherlands Organization for Scientific Research
Dendritic spines are small actin-rich protrusions that form the postsynaptic part of most excitatory synapses. They play critical roles in synaptic function and exhibit a striking degree of structural plasticity, which is closely linked to changes in strength of synaptic connections. Here the authors summarize recent work that has revealed an important relationship between the microtubule and actin cytoskeleton in controlling spine morphology and plasticity. Dynamic microtubules and the proteins that specifically associate with the growing microtubule plus-ends recently emerged as temporal and spatial regulators of actin organization, which controls dynamic changes in structure and function of dendritic spines.
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