Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP

Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia

(2016) Ana Jovičić et al.   JOURNAL OF NEUROCHEMISTRY

Repeating mistakes

(2016) Natasha Bray   NATURE REVIEWS NEUROSCIENCE

Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins

(2015) Eileen Chen et al.   BIOCHIMIE

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

(2015) Chantelle F. Sephton et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

(2015) Alyssa N. Coyne et al.   HUMAN MOLECULAR GENETICS

Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases

(2015) Panchanan Maiti et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1

(2015) Naotaka Sekiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP

(2015) Nikita Vasilyev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile X mental retardation protein: from autism to neurodegenerative disease

(2015) Hansen Wang   Frontiers in Cellular Neuroscience

Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms

(2015) Weixiang Guo et al.   Cell Reports

The role of TDP-43 in the pathogenesis of ALS and FTLD: Figure 1

(2015) Marco Baralle et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

(2014) Shelly A. Buffington et al.   Annual Review of Neuroscience

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

(2014) A. N. Coyne et al.   JOURNAL OF NEUROSCIENCE

FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry

(2014) Giorgio La Fata et al.   NATURE NEUROSCIENCE

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome

(2014) Sabiha Abekhoukh et al.   Frontiers in Cellular Neuroscience

Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density

(2014) Laurent Ferron et al.   Nature Communications

Meet the players: local translation at the synapse

(2014) Sandra M. Fernandez-Moya et al.   Frontiers in Molecular Neuroscience

The fragile X syndrome–autism comorbidity: what do we really know?

(2014) Leonard Abbeduto et al.   Frontiers in Genetics

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

The translation of translational control by FMRP: therapeutic targets for FXS

(2013) Jennifer C Darnell et al.   NATURE NEUROSCIENCE

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

TDP-43-mediated neurodegeneration: towards a loss-of-function hypothesis?

(2013) Lies Vanden Broeck et al.   TRENDS IN MOLECULAR MEDICINE

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

Fragile X mental retardation protein and synaptic plasticity

(2013) Michael S Sidorov et al.   Molecular Brain

The FMRP regulon: from targets to disease convergence

(2013) Esperanza Fernández et al.   Frontiers in Neuroscience

Evidence of neurodegeneration in autism spectrum disorder

(2013) Janet K Kern et al.   Translational Neurodegeneration

TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1

(2012) Pritha Majumder et al.   ACTA NEUROPATHOLOGICA

Synaptic structure and function

(2012) Antoine Triller et al.   CURRENT OPINION IN NEUROBIOLOGY

Neurodegeneration-associated TDP-43 Interacts with Fragile X Mental Retardation Protein (FMRP)/Staufen (STAU1) and Regulates SIRT1 Expression in Neuronal Cells

(2012) Zhipeng Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice

(2012) Lien-Szu Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signalling pathways of fragile X syndrome

(2012) Sabarinath Jayaseelan et al.   NATURE

Fragile Mental Retardation Protein Interacts with the RNA-Binding Protein Caprin1 in Neuronal RiboNucleoProtein Complexes

(2012) Rachid El Fatimy et al.   PLoS One

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

Modulation of dendritic spines and synaptic function by Rac1: A possible link to Fragile X syndrome pathology

(2011) Odelia Y.N. Bongmba et al.   BRAIN RESEARCH

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders

(2011) Silvia De Rubeis et al.   Journal of Neurodevelopmental Disorders

Local RNA Translation at the Synapse and in Disease

(2011) L. Liu-Yesucevitz et al.   JOURNAL OF NEUROSCIENCE

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

(2011) Edward B. Lee et al.   NATURE REVIEWS NEUROSCIENCE

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

(2010) C. Lagier-Tourenne et al.   HUMAN MOLECULAR GENETICS

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes

(2010) Chantelle F. Sephton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

(2010) E. K. Osterweil et al.   JOURNAL OF NEUROSCIENCE

Essential role of Rac1 and Rac3 GTPases in neuronal development

(2009) Sara Corbetta et al.   FASEB JOURNAL

TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis

(2009) Lien-Szu Wu et al.   GENESIS

Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery

(2009) Brian D. Freibaum et al.   JOURNAL OF PROTEOME RESEARCH

A Novel Function for Fragile X Mental Retardation Protein in Translational Activation

(2009) Elias G Bechara et al.   PLOS BIOLOGY

The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP

(2008) Ilaria Napoli et al.   CELL

TDP-43 Overexpression Enhances Exon 7 Inclusion during the Survival of Motor Neuron Pre-mRNA Splicing

(2008) Jayarama Krishnan Bose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

(2008) I.-Fan Wang et al.   JOURNAL OF NEUROCHEMISTRY

The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control

(2008) Ming-Chih Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA

(2008) L. Menon et al.   RNA

TDP-43: an emerging new player in neurodegenerative diseases

(2008) I-Fan Wang et al.   TRENDS IN MOLECULAR MEDICINE