Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation

Is folic acid good for everyone?

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What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies

(2016) E H Reynolds   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns

(2016) Bonnie R. Joubert et al.   Nature Communications

DNA Methylation Profiling at Single-Base Resolution Reveals Gestational Folic Acid Supplementation Influences the Epigenome of Mouse Offspring Cerebellum

(2016) Subit Barua et al.   Frontiers in Neuroscience

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

(2015) Karen E Christensen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-dose folic acid supplementation alters the human sperm methylome and is influenced by theMTHFRC677T polymorphism

(2015) Mahmoud Aarabi et al.   HUMAN MOLECULAR GENETICS

MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

(2015) Mancheng Gong et al.   PLoS One

Developmental windows of susceptibility for epigenetic inheritance through the male germline

(2015) Lundi Ly et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Parenting from before conception

(2014) M. Lane et al.   SCIENCE

Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid

(2014) Subit Barua et al.   Epigenetics & Chromatin

Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the Netherlands

(2014) Renata Bortolus et al.   BMC Pregnancy and Childbirth

Stability of DNA Methylation Patterns in Mouse Spermatogonia Under Conditions of MTHFR Deficiency and Methionine Supplementation1

(2013) Justine L. Garner et al.   BIOLOGY OF REPRODUCTION

Mutation in Folate Metabolism Causes Epigenetic Instability and Transgenerational Effects on Development

(2013) Nisha Padmanabhan et al.   CELL

Folic acid and cancer—where are we today?

(2013) Joshua W Miller et al.   LANCET

Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring

(2013) Karen K. Y. Sie et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Imprinted genes in mouse placental development and the regulation of fetal energy stores

(2013) S J Tunster et al.   REPRODUCTION

Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

(2013) R. Lambrot et al.   Nature Communications

Moderately high intake of folic acid has a negative impact on mouse embryonic development

(2012) Leonie G. Mikael et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice

(2012) Breanne G. Swayne et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Prevention of Neural-Tube Defects with Periconceptional Folic Acid, Methylfolate, or Multivitamins?

(2011) Andrew E. Czeizel et al.   ANNALS OF NUTRITION AND METABOLISM

Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes

(2011) Tiffany D. Schaible et al.   HUMAN MOLECULAR GENETICS

Epigenetic Alterations in Sperm DNA Associated with Testicular Cancer Treatment

(2011) Donovan Chan et al.   TOXICOLOGICAL SCIENCES

Unmetabolized serum folic acid and its relation to folic acid intake from diet and supplements in a nationally representative sample of adults aged ≥60 y in the United States

(2010) Regan L Bailey et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High intake of folic acid disrupts embryonic development in mice

(2010) Laura Pickell et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Strain-Specific Defects in Testicular Development and Sperm Epigenetic Patterns in 5,10-Methylenetetrahydrofolate Reductase-Deficient Mice

(2010) Donovan Chan et al.   ENDOCRINOLOGY

Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair

(2010) Erin Knock et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake

(2009) S. W. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Superovulation alters the expression of imprinted genes in the midgestation mouse placenta

(2008) Amanda L. Fortier et al.   HUMAN MOLECULAR GENETICS