标题
Finding the sweet spot: the role of nature and nurture in medicinal chemistry
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 11, Issue 5, Pages 355-365
出版商
Springer Nature
发表日期
2012-04-30
DOI
10.1038/nrd3701
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- 5th Drug Desing & Lead Discovery Conference 2009: Lead Finding Strategies and Optimization Case Studies
- (2015) G.M. Keseru DRUGS OF THE FUTURE
- Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry
- (2012) Alan Nadin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Impact of Lipophilic Efficiency on Compound Quality
- (2012) Ákos Tarcsay et al. JOURNAL OF MEDICINAL CHEMISTRY
- Quantifying the chemical beauty of drugs
- (2012) G. Richard Bickerton et al. Nature Chemistry
- Ten key issues in modern flow chemistry
- (2011) Jens Wegner et al. CHEMICAL COMMUNICATIONS
- Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
- (2011) Antonia F. Stepan et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Publisher's Note
- (2011) CURRENT OPINION IN CHEMICAL BIOLOGY
- Molecular complexity and fragment-based drug discovery: ten years on
- (2011) Andrew R Leach et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Fragment screening to predict druggability (ligandability) and lead discovery success
- (2011) Fredrik N.B. Edfeldt et al. DRUG DISCOVERY TODAY
- Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity
- (2011) Robert J. Young et al. DRUG DISCOVERY TODAY
- Drug discovery in the next decade: innovation needed ASAP
- (2011) Youssef L. Bennani DRUG DISCOVERY TODAY
- Application of drug efficiency index in drug discovery: a strategy towards low therapeutic dose
- (2011) Dino Montanari et al. Expert Opinion on Drug Discovery
- Assessing the lipophilicity of fragments and early hits
- (2011) Paul N. Mortenson et al. JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
- What Do Medicinal Chemists Actually Make? A 50-Year Retrospective
- (2011) W. Patrick Walters et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
- (2011) Stephen D. Roughley et al. JOURNAL OF MEDICINAL CHEMISTRY
- BINANA: A novel algorithm for ligand-binding characterization
- (2011) Jacob D. Durrant et al. JOURNAL OF MOLECULAR GRAPHICS & MODELLING
- Shielded Hydrogen Bonds as Structural Determinants of Binding Kinetics: Application in Drug Design
- (2011) Peter Schmidtke et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Collective synthesis of natural products by means of organocascade catalysis
- (2011) Spencer B. Jones et al. NATURE
- How were new medicines discovered?
- (2011) David C. Swinney et al. NATURE REVIEWS DRUG DISCOVERY
- The influence of the 'organizational factor' on compound quality in drug discovery
- (2011) Paul D. Leeson et al. NATURE REVIEWS DRUG DISCOVERY
- Impact of high-throughput screening in biomedical research
- (2011) Ricardo Macarron et al. NATURE REVIEWS DRUG DISCOVERY
- Probing the links between in vitro potency, ADMET and physicochemical parameters
- (2011) M. Paul Gleeson et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase
- (2011) P. W. Snyder et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extent of enthalpy-entropy compensation in protein-ligand interactions
- (2011) Tjelvar S. G. Olsson et al. PROTEIN SCIENCE
- An assessment of R&D productivity in the pharmaceutical industry
- (2011) Nicola Dimitri TRENDS IN PHARMACOLOGICAL SCIENCES
- Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
- (2011) Alexander Alex et al. MedChemComm
- Molecular obesity, potency and other addictions in drug discovery
- (2011) Michael M. Hann MedChemComm
- Thermodynamics of Ligand Binding and Efficiency
- (2011) Charles H. Reynolds et al. ACS Medicinal Chemistry Letters
- Analysis of in vitro bioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds
- (2011) Christopher Southan et al. Journal of Cheminformatics
- Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
- (2010) Travis T. Wager et al. ACS Chemical Neuroscience
- Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties
- (2010) Travis T. Wager et al. ACS Chemical Neuroscience
- Factors Determining the Selection of Organic Reactions by Medicinal Chemists and the Use of These Reactions in Arrays (Small Focused Libraries)
- (2010) Tony W. J. Cooper et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Thermodynamics guided lead discovery and optimization
- (2010) György G. Ferenczy et al. DRUG DISCOVERY TODAY
- Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity
- (2010) Alan P. Hill et al. DRUG DISCOVERY TODAY
- Drug efficiency: a new concept to guide lead optimization programs towards the selection of better clinical candidates
- (2010) Simone Braggio et al. Expert Opinion on Drug Discovery
- Lipophilicity in drug discovery
- (2010) Michael J Waring Expert Opinion on Drug Discovery
- Enthalpic Efficiency of Ligand Binding
- (2010) György G. Ferenczy et al. Journal of Chemical Information and Modeling
- Congeneric but Still Distinct: How Closely Related Trypsin Ligands Exhibit Different Thermodynamic and Structural Properties
- (2010) Tobias Brandt et al. JOURNAL OF MOLECULAR BIOLOGY
- The Developability Classification System: Application of Biopharmaceutics Concepts to Formulation Development
- (2010) James M. Butler et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Physicochemical property profiles of marketed drugs, clinical candidates and bioactive compounds
- (2009) Christian Tyrchan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability
- (2009) Michael J. Waring BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Simple Size-Independent Measure of Ligand Efficiency
- (2009) J. Willem M. Nissink Journal of Chemical Information and Modeling
- Heteroaromatic Rings of the Future
- (2009) William R. Pitt et al. JOURNAL OF MEDICINAL CHEMISTRY
- The rise of fragment-based drug discovery
- (2009) Christopher W. Murray et al. Nature Chemistry
- Adding calorimetric data to decision making in lead discovery: a hot tip
- (2009) John E. Ladbury et al. NATURE REVIEWS DRUG DISCOVERY
- The influence of lead discovery strategies on the properties of drug candidates
- (2009) György M. Keserü et al. NATURE REVIEWS DRUG DISCOVERY
- Physiochemical drug properties associated with in vivo toxicological outcomes
- (2008) Jason D. Hughes et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Two ‘Golden Ratio’ indices in fragment-based drug discovery
- (2008) Masaya Orita et al. DRUG DISCOVERY TODAY
- A structural biology view of target drugability
- (2008) Ursula Egner et al. Expert Opinion on Drug Discovery
- Ligand Binding Efficiency: Trends, Physical Basis, and Implications
- (2008) Charles H. Reynolds et al. JOURNAL OF MEDICINAL CHEMISTRY
- Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
- (2008) M. Paul Gleeson JOURNAL OF MEDICINAL CHEMISTRY
- The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design
- (2008) Tjelvar S.G. Olsson et al. JOURNAL OF MOLECULAR BIOLOGY
- Calculation of Molecular Lipophilicity: State-of-the-Art and Comparison of LogP Methods on more than 96,000 Compounds
- (2008) Raimund Mannhold et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search