期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 28, 期 12, 页码 3395-3404出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msr176
关键词
subtilases; fungi; systemic human pathogens; serine proteases
资金
- NIH-NIAID [1R01AI070891]
- [NIH-U54-AI65359]
Phylogenetic analysis of the most common clade of fungal proteases, proteinase K, showed that gene family size changed independently in fungi, pathogenic to invertebrates (Hypocreales) and vertebrates (Onygenales). Interestingly, simultaneous expansions in the S8 and S53 families of subtilases in a single fungal species are rare. Our analysis finds that closely related systemic human pathogens may not show the same gene family expansions, and that related pathogens and nonpathogens may show the same type of gene family expansion. Therefore, the number of proteases does not appear to relate to pathogenicity. Instead, we hypothesize that the number of fungal serine proteases in a species is related to the use of the animal as a food source, whether it is dead or alive.
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