Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

(2010) Maxwell D. Cummings et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease

(2010) X. Tong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

(2010) O. Lenz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents

(2010) Magnus Nilsson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

(2010) M. N. L. Nalam et al.   JOURNAL OF VIROLOGY

Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients

(2009) Simone Susser et al.   HEPATOLOGY

Identification of HCV protease inhibitor resistance mutations by selection pressure-based method

(2009) P. Qiu et al.   NUCLEIC ACIDS RESEARCH

trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation

(2009) MinKyung Yi et al.   PLoS Pathogens

Characterization of resistance mutations against HCV ketoamide protease inhibitors

(2008) X TONG et al.   ANTIVIRAL RESEARCH

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034

(2008) S. Bogen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350

(2008) Pierre Raboisson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients

(2008) Thomas Kuntzen et al.   HEPATOLOGY

Discovery and Structure−Activity Relationship of P1−P3Ketoamide Derived Macrocyclic Inhibitors of Hepatitis C Virus NS3 Protease

(2008) Srikanth Venkatraman et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant Variants

(2008) Michael D. Altman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY