A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

Microfabricated reciprocating micropump for intracochlear drug delivery with integrated drug/fluid storage and electronically controlled dosing

(2016) Vishal Tandon et al.   LAB ON A CHIP

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

(2014) Aurelie Vivares et al.   XENOBIOTICA

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

(2013) Jorrit J. Hornberg et al.   DRUG DISCOVERY TODAY

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Pulmonary Artery Embolization for Refractory Hypoxemia Caused by Invasive Mucinous Adenocarcinoma

(2013) Frederique Trietsch et al.   Journal of Thoracic Oncology

Potentials and limitations of nonclinical safety assessment for predicting clinical adverse drug reactions: correlation analysis of 142 approved drugs in Japan

(2013) Chihiro Tamaki et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Effects of Culture Duration on Gene Expression of P450 Isoforms, Uptake and Efflux Transporters in Primary Hepatocytes Cultured in the Absence and Presence of Interleukin- 6: Implications for Experimental Design for the Evaluation of Downregulatory Effects of Biotherapeutics

(2012) Qian Yang et al.   CURRENT DRUG METABOLISM

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

The Airway Epithelium: Soldier in the Fight against Respiratory Viruses

(2011) M. Vareille et al.   CLINICAL MICROBIOLOGY REVIEWS

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

(2010) J A DiMasi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

(2010) J. R. Rock et al.   Disease Models & Mechanisms

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Catecholamines induce an inflammatory response in human hepatocytes

(2009) Caroline Aninat et al.   CRITICAL CARE MEDICINE

Fabrication Methods and Performance of Low-Permeability Microfluidic Components for a Miniaturized Wearable Drug Delivery System

(2009) M.J. Mescher et al.   JOURNAL OF MICROELECTROMECHANICAL SYSTEMS

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP