Microfabricated mammalian organ systems and their integration into models of whole animals and humans

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Design Optimization of Liquid-Phase Flow Patterns for Microfabricated Lung on a Chip

(2012) C. Long et al.   ANNALS OF BIOMEDICAL ENGINEERING

Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: Results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen

(2012) Albert P. Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Parallel Artificial Membrane Permeability Assay (PAMPA) - Is it Better than Caco-2 for Human Passive Permeability Prediction?

(2012) J. M. Reis et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

(2012) Elisabetta Iori et al.   PLoS One

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system

(2011) Xiufang Guo et al.   BIOMATERIALS

The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle

(2011) Sara Hinds et al.   BIOMATERIALS

Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform

(2011) Anupama Natarajan et al.   BIOMATERIALS

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

(2011) Yosuke Nakao et al.   Biomicrofluidics

A flexible bioreactor system for constructing in vitro tissue and organ models

(2011) Federico Vozzi et al.   BIOTECHNOLOGY AND BIOENGINEERING

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Retrograde heart perfusion: The Langendorff technique of isolated heart perfusion

(2011) Robert M. Bell et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Development of a three-dimensional, all-human in vitro model of the blood–brain barrier using mono-, co-, and tri-cultivation Transwell models

(2011) Kathryn Hatherell et al.   JOURNAL OF NEUROSCIENCE METHODS

In vitro 3D collective sprouting angiogenesis under orchestrated ANG-1 and VEGF gradients

(2011) Yoojin Shin et al.   LAB ON A CHIP

Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip

(2011) Anna Grosberg et al.   LAB ON A CHIP

Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection

(2011) Sifeng Mao et al.   LAB ON A CHIP

Design of pressure-driven microfluidic networks using electric circuit analogy

(2011) Kwang W. Oh et al.   LAB ON A CHIP

Metabolic Control Through Hepatocyte and Adipose Tissue Cross-Talk in a Multicompartmental Modular Bioreactor

(2011) Maria Angela Guzzardi et al.   TISSUE ENGINEERING PART A

A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues

(2011) Thomas Boudou et al.   TISSUE ENGINEERING PART A

Defined Electrical Stimulation Emphasizing Excitability for the Development and Testing of Engineered Skeletal Muscle

(2011) Alastair Khodabukus et al.   TISSUE ENGINEERING PART C-METHODS

Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip

(2011) J E Snyder et al.   Biofabrication

The airway epithelium: more than just a structural barrier

(2011) Anthony Tam et al.   Therapeutic Advances in Respiratory Disease

The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

(2010) Ian L. Jones et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

Fabrication of Two-Layered Channel System with Embedded Electrodes to Measure Resistance Across Epithelial and Endothelial Barriers

(2010) Nicholas J. Douville et al.   ANALYTICAL CHEMISTRY

Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes

(2010) Lin Wang et al.   BIOMATERIALS

Tissue engineering the mechanosensory circuit of the stretch reflex arc: Sensory neuron innervation of intrafusal muscle fibers

(2010) John W. Rumsey et al.   BIOMATERIALS

Biohybrid thin films for measuring contractility in engineered cardiovascular muscle

(2010) Patrick W. Alford et al.   BIOMATERIALS

A defined long-term in vitro tissue engineered model of neuromuscular junctions

(2010) Mainak Das et al.   BIOMATERIALS

Multilayer microfluidic PEGDA hydrogels

(2010) Michael P. Cuchiara et al.   BIOMATERIALS

Micro-scale and microfluidic devices for neurobiology

(2010) Anne M Taylor et al.   CURRENT OPINION IN NEUROBIOLOGY

Integration ofin silicoandin vitroplatforms for pharmacokinetic–pharmacodynamic modeling

(2010) Jong Hwan Sung et al.   Expert Opinion on Drug Metabolism & Toxicology

Promises, challenges and future directions of μCCAs

(2010) Mandy B. Esch et al.   JOURNAL OF BIOTECHNOLOGY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century☆

(2010) Andrew F.M. Johnstone et al.   NEUROTOXICOLOGY

Investigation of portable in situ fluorescence optical detection for microfluidic 3D cell culture assays

(2010) Jong-ryul Choi et al.   OPTICS LETTERS

A New Target for Amyloid Beta Toxicity Validated by Standard and High-Throughput Electrophysiology

(2010) Kucku Varghese et al.   PLoS One

Measurement of Contractile Stress Generated by Cultured Rat Muscle on Silicon Cantilevers for Toxin Detection and Muscle Performance Enhancement

(2010) Kerry Wilson et al.   PLoS One

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Neuromuscular Junction Formation Between Human Stem-Cell-Derived Motoneurons and Rat Skeletal Muscle in a Defined System

(2010) Xiufang Guo et al.   TISSUE ENGINEERING PART C-METHODS

Biofabrication of a three-dimensional liver micro-organ as anin vitrodrug metabolism model

(2010) Robert Chang et al.   Biofabrication

A microfluidic wound-healing assay for quantifying endothelial cell migration

(2009) Andries D. van der Meer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices

(2009) Jong Hwan Sung et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

(2009) Gretchen J. Mahler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies

(2009) Paul M. van Midwoud et al.   BIOTECHNOLOGY AND BIOENGINEERING

The effects of mechanical forces on intestinal physiology and pathology

(2009) Christopher P. Gayer et al.   CELLULAR SIGNALLING

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Co-culture of epithelial cells and bacteria for investigating host–pathogen interactions

(2009) Jeongyun Kim et al.   LAB ON A CHIP

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes

(2009) P. Linder et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

(2009) Leon M. Bellan et al.   Soft Matter

High-Content Drug Screening with Engineered Musculoskeletal Tissues

(2009) Herman Vandenburgh   TISSUE ENGINEERING PART B-REVIEWS

Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays

(2008) Amy L. Paguirigan et al.   BIOESSAYS

Substrate Stiffness Affects the Functional Maturation of Neonatal Rat Ventricular Myocytes

(2008) Jeffrey G. Jacot et al.   BIOPHYSICAL JOURNAL

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quantitative evaluation of cardiomyocyte contractility in a 3D microenvironment

(2008) Jinseok Kim et al.   JOURNAL OF BIOMECHANICS

Regeneration and characterization of adult mouse hippocampal neurons in a defined in vitro system

(2008) Kucku Varghese et al.   JOURNAL OF NEUROSCIENCE METHODS

A Combined Pharmacokinetic–Pharmacodynamic (PK–PD) Model for Tumor Growth in the Rat with UFT Administration

(2008) Jong Hwan Sung et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

(2008) Bo Ma et al.   LAB ON A CHIP

Drug-screening platform based on the contractility of tissue-engineered muscle

(2008) Herman Vandenburgh et al.   MUSCLE & NERVE

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS