On being the right size: scaling effects in designing a human-on-a-chip

Human hepatocytes as an effective alternative experimental system for the evaluation of human drug properties: General concepts and assay procedures

(2016) Albert Li   ALTEX-Alternatives to Animal Experimentation

Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems

(2013) J. P. Wikswo et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Allometry of brain metabolism: Fig. 1.

(2013) Robert S. Balaban   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels

(2013) Fahmeed Hyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel method to differentiate 3T3 L1 cells in vitro to produce highly sensitive adipocytes for a GLUT4 mediated glucose uptake using fluorescent glucose analog

(2013) Divya Vishwanath et al.   Journal of Cell Communication and Signaling

Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2012) Yuki IMURA et al.   ANALYTICAL SCIENCES

Microtechnology for Mimicking In Vivo Tissue Environment

(2012) Jong Hwan Sung et al.   ANNALS OF BIOMEDICAL ENGINEERING

Artificial Oxygen Carriers: Renewed Commercial Interest and Scientific/Technological Advances

(2012) Jan Simoni   ARTIFICIAL ORGANS

Engineering microscale topographies to control the cell–substrate interface

(2012) Mehdi Nikkhah et al.   BIOMATERIALS

Engineers are from PDMS-land, Biologists are from Polystyrenia

(2012) Erwin Berthier et al.   LAB ON A CHIP

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia

(2012) Elisabetta Iori et al.   PLoS One

Adipose Tissue Engineering in Three-Dimensional Levitation Tissue Culture System Based on Magnetic Nanoparticles

(2012) Alexes C. Daquinag et al.   TISSUE ENGINEERING PART C-METHODS

Rapid Prototyping of Arrayed Microfluidic Systems in Polystyrene for Cell-Based Assays

(2011) Edmond W. K. Young et al.   ANALYTICAL CHEMISTRY

Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

(2011) Christopher Moraes et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

(2011) M.B. Esch et al.   Annual Review of Biomedical Engineering

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

(Micro)managing the mechanical microenvironment

(2011) Christopher Moraes et al.   Integrative Biology

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

(2011) Wu Yin et al.   JOURNAL OF LIPID RESEARCH

Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution

(2011) Suzana Herculano-Houzel   PLoS One

Current Methods of Adipogenic Differentiation of Mesenchymal Stem Cells

(2011) Michelle A. Scott et al.   STEM CELLS AND DEVELOPMENT

Metabolic Control Through Hepatocyte and Adipose Tissue Cross-Talk in a Multicompartmental Modular Bioreactor

(2011) Maria Angela Guzzardi et al.   TISSUE ENGINEERING PART A

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Allometry of the mammalian intracellular pulmonary surfactant system

(2010) André Wirkes et al.   JOURNAL OF APPLIED PHYSIOLOGY

Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology

(2010) Olivier Toussaint et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oxygen gradients for open well cellular cultures via microfluidic substrates

(2010) Joe F. Lo et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

(2010) Nicholas J. Douville et al.   LAB ON A CHIP

A general basis for quarter-power scaling in animals

(2010) J. R. Banavar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

High throughput methods applied in biomaterial development and discovery

(2009) Andrew L. Hook et al.   BIOMATERIALS

In vitro liver model using microfabricated scaffolds in a modular bioreactor

(2009) Bruna Vinci et al.   Biotechnology Journal

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Study of the Crosstalk Between Hepatocytes and Endothelial Cells Using a Novel Multicompartmental Bioreactor: A Comparison Between Connected Cultures and Cocultures

(2009) Maria Angela Guzzardi et al.   TISSUE ENGINEERING PART A

Recent advances in three-dimensional multicellular spheroid culture for biomedical research

(2008) Ruei-Zhen Lin et al.   Biotechnology Journal

Connected Culture of Murine Hepatocytes and Human Umbilical Vein Endothelial Cells in a Multicompartmental Bioreactor

(2008) Federico Vozzi et al.   TISSUE ENGINEERING PART A

Sizing Up Allometric Scaling Theory

(2008) Van M. Savage et al.   PLoS Computational Biology

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS