Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Bedding Material Affects Mechanical Thresholds, Heat Thresholds, and Texture Preference

(2016) Francie Moehring et al.   JOURNAL OF PAIN

Total Western Diet Alters Mechanical and Thermal Sensitivity and Prolongs Hypersensitivity Following Complete Freund's Adjuvant in Mice

(2016) Stacie K. Totsch et al.   JOURNAL OF PAIN

Perspective: Equality need not be painful

(2016) Jeffrey S. Mogil   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

1,500 scientists lift the lid on reproducibility

(2016) Monya Baker   NATURE

Irreproducibility in Preclinical Biomedical Research: Perceptions, Uncertainties, and Knowledge Gaps

(2016) Michael F. Jarvis et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Social transfer of pain in mice

(2016) M. L. Smith et al.   Science Advances

Chronic psychosocial stress induces visceral hyperalgesia in mice

(2016) Mónica Tramullas et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Revealing a latent variable: Individual differences in affective response to repeated injections.

(2015) Cigdem Aydin et al.   BEHAVIORAL NEUROSCIENCE

Mice undergoing neuropathic pain induce anxiogenic-like effects and hypernociception in cagemates

(2015) Daniela Baptista-de-Souza et al.   BEHAVIOURAL PHARMACOLOGY

Reducing Social Stress Elicits Emotional Contagion of Pain in Mouse and Human Strangers

(2015) Loren J. Martin et al.   CURRENT BIOLOGY

Evidence for a distinct neuro-immune signature in rats that develop behavioural disability after nerve injury

(2015) Paul J Austin et al.   Journal of Neuroinflammation

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Neonatal stress from limited bedding elicits visceral hyperalgesia in adult rats

(2015) Yumei Guo et al.   NEUROREPORT

Neonatal handling (resilience) attenuates water-avoidance stress induced enhancement of chronic mechanical hyperalgesia in the rat

(2015) Pedro Alvarez et al.   NEUROSCIENCE LETTERS

Increasing placebo responses over time in U.S. clinical trials of neuropathic pain

(2015) Alexander H. Tuttle et al.   PAIN

Estimating the reproducibility of psychological science

(2015)   SCIENCE

Experimenter effects on behavioral test scores of eight inbred mouse strains under the influence of ethanol

(2014) Martin Bohlen et al.   BEHAVIOURAL BRAIN RESEARCH

The effect of acclimatization and ambient temperature on heat withdrawal threshold in rats

(2014) J. Vítková et al.   EUROPEAN JOURNAL OF PAIN

Policy: NIH plans to enhance reproducibility

(2014) Francis S. Collins et al.   NATURE

Olfactory exposure to males, including men, causes stress and related analgesia in rodents

(2014) Robert E Sorge et al.   NATURE METHODS

An open investigation of the reproducibility of cancer biology research

(2014) Timothy M Errington et al.   eLife

Stress in the Adult Rat Exacerbates Muscle Pain Induced by Early-Life Stress

(2013) Pedro Alvarez et al.   BIOLOGICAL PSYCHIATRY

Ketogenic Diets and Thermal Pain: Dissociation of Hypoalgesia, Elevated Ketones, and Lowered Glucose in Rats

(2013) David N. Ruskin et al.   JOURNAL OF PAIN

Announcement: Reducing our irreproducibility

(2013)   NATURE

Effects of Methyl Donor Diets on Incisional Pain in Mice

(2013) Yuan Sun et al.   PLoS One

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Psychophysics of a Nociceptive Test in the Mouse: Ambient Temperature as a Key Factor for Variation

(2012) Ivanne Pincedé et al.   PLoS One

Effects of Glycemic Regulation on Chronic Postischemia Pain

(2011) Marie-Christine Ross-Huot et al.   ANESTHESIOLOGY

Environmentally induced antinociception and hyperalgesia in rats and mice

(2011) Alianda Maira Cornélio et al.   BRAIN RESEARCH

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction

(2011) Jeffrey S Mogil et al.   NATURE NEUROSCIENCE

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

Fish oil concentrate delays sensitivity to thermal nociception in mice

(2011) Jyothi M. Veigas et al.   PHARMACOLOGICAL RESEARCH

Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study

(2011) S. Helene Richter et al.   PLoS One

Effects of soy diet on inflammation-induced primary and secondary hyperalgesia in rat⋆

(2010) Jasenka Borzan et al.   EUROPEAN JOURNAL OF PAIN

Varying Perceived Social Threat Modulates Pain Behavior in Male Mice

(2010) Dale J. Langford et al.   JOURNAL OF PAIN

Taming anxiety in laboratory mice

(2010) Jane L Hurst et al.   NATURE METHODS

Housing environment influences the need for pain relief during post-operative recovery in mice

(2010) T.M. Pham et al.   PHYSIOLOGY & BEHAVIOR

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Enriched environment and the recovery from inflammatory pain: Social versus physical aspects and their interaction

(2009) Anne F. Gabriel et al.   BEHAVIOURAL BRAIN RESEARCH

Iron-Deficiency Sensitizes Mice to Acute Pain Stimuli and Formalin-Induced Nociception

(2009) Pascal Dowling et al.   JOURNAL OF NUTRITION

Effects of Removal of Dietary Polyunsaturated Fatty Acids on Plasma Extravasation and Mechanical Allodynia in a Trigeminal Neuropathic Pain Model

(2009) Yasmina B Martin et al.   Molecular Pain

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS

Animal models of pain: progress and challenges

(2009) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Individual housing of mice — Impact on behaviour and stress responses

(2009) Saskia S. Arndt et al.   PHYSIOLOGY & BEHAVIOR

A Trouble Shared Is a Trouble Halved: Social Context and Status Affect Pain in Mouse Dyads

(2009) Laura Gioiosa et al.   PLoS One

Stress-induced analgesia

(2009) Ryan K. Butler et al.   PROGRESS IN NEUROBIOLOGY

Social approach to pain in laboratory mice

(2009) Dale J. Langford et al.   Social Neuroscience

A Novel Tool for the Assessment of Pain: Validation in Low Back Pain

(2009) Joachim Scholz et al.   PLOS MEDICINE

Housing supplementation decreases the magnitude of inflammation-induced nociception in rats

(2008) J TALL   BEHAVIOURAL BRAIN RESEARCH

Predictive validity of animal pain models? A comparison of the pharmacokinetic–pharmacodynamic relationship for pain drugs in rats and humans

(2008) G.T. Whiteside et al.   NEUROPHARMACOLOGY

Selective disturbance of pain sensitivity after social isolation

(2008) Gabor Tuboly et al.   PHYSIOLOGY & BEHAVIOR

Inorganic arsenic exposure affects pain behavior and inflammatory response in rat

(2008) P AGUIRREBANUELOS et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY