Article
Neurosciences
Paul G. Green, Pedro Alvarez, Jon D. Levine
Summary: The study showed that adult rats who experienced early-life stress exhibited persistent muscle mechanical hyperalgesia, which could be significantly reduced by probiotics or non-absorbable antibiotics. Therefore, modulation of the gut microbiome using probiotics or antibiotics may provide a novel therapeutic approach for treating chronic musculoskeletal pain.
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Endocrinology & Metabolism
Kangkang Huang, Yunlai Liang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study discovered significant variations in adiponectin, nesfatin-1, IL-6, and TNF-alpha levels among healthy individuals, prediabetic patients, and type 2 diabetes mellitus patients, indicating a gradual change during the progression from a healthy condition to diabetes via prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Summary: The study shows that human Tregs respond positively to proinflammatory cytokines, enhancing proliferation without affecting their lineage identity or function, providing a potential method for therapeutic Treg manufacturing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Immunology
Alexandria Lozowchuk, Judith E. Carroll, Calvin Hobel, Mary Coussons-Read, Christine Dunkel Schetter, Kharah M. Ross
Summary: This study explored the relationship between partner relationship quality and inflammatory markers IL-6, IL-10, and TNF-alpha during pregnancy and the postpartum period. The findings suggest that lower partner support may be associated with reduced inflammation regulation, with potential consequences for maternal health and well-being.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Chemistry, Medicinal
Alvaro Nobrega de Melo Madureira, Joao Ricardhis Saturnino de Oliveira, Vera Lucia de Menezes Lima
Summary: Interleulcin-6 (IL-6) is a myokine that can be released by exercising skeletal muscle. It activates the PI3K-Akt pathway to enhance insulin signaling and glycogen synthesis. IL-6 also increases GLUT-4 vesicle mobilization and may contribute to muscle hypertrophy by activating mTORC1 and promoting contractile protein synthesis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
M. L. Cuellar-Nunez, E. Gonzalez de Mejia, G. Loarca-Pina
Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Neurosciences
Donna L. Gruol, Delilah Calderon, Katharine French, Claudia Melkonian, Salvador Huitron-Resendiz, Chelsea Cates-Gatto, Amanda J. Roberts
Summary: The neuroimmune system of the brain, primarily composed of astrocytes and microglia, regulates homeostatic mechanisms crucial for normal brain function. Alcohol consumption and neuroimmune factors, such as proinflammatory cytokines IL-6 and TNF-alpha, disrupt this regulation by acting on common targets in the brain. Recent studies suggest that IL-6 plays a role in alcohol drinking and its effects on brain activity, but more research is needed.
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Ilin Kandilarov, Petya Gardjeva, Maria Georgieva-Kotetarova, Hristina Zlatanova, Natalia Vilmosh, Ivanka Kostadinova, Mariana Katsarova, Kiril Atliev, Stela Dimitrova
Summary: This study aimed to investigate the effects of two combined plant extracts, rich in flavonoids, on cytokine levels in rats subjected to acute and chronic stress models. The results showed that these combined extracts had a more pronounced effect in reducing cytokine levels compared to individual plant extracts.
Article
Biochemistry & Molecular Biology
Katia Azarfar, Parichehreh Yaghmaei, Mahsa M. Amoli, Nasim Hayati-Roodbari, Azadeh Ebrahim-Habibi
Summary: The study aimed to observe the effects of silymarin on localized insulin-generated amyloidosis. It was found that incubating regular insulin and injecting it subcutaneously into rats led to the formation of amyloid fibrils, while silymarin could decrease the deposition of amyloids. Furthermore, silymarin also attenuated the concentration and gene expression of inflammatory factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah
Summary: The current study evaluated the anti-arthritic activity of n-hexane and aqueous extracts of Cassia absus seeds. The extracts showed significant inhibition of paw edema and reduction in paw size and joint diameter. The extracts also improved the levels of inflammatory and oxidative biomarkers. Polymerase chain reaction investigation revealed the modulation of various inflammatory factors by the extracts. In conclusion, Cassia absus can effectively alleviate arthritis symptoms by modulating oxidative and inflammatory biomarkers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Psychiatry
Hannah E. Specht, Nina Mannig, Meriem Belheouane, Nadia Andrea Andreani, Klaus Tenbrock, Ronald Biemann, Katrin Borucki, Brigitte Dahmen, Astrid Dempfle, John F. Baines, Beate Herpertz-Dahlmann, Jochen Seitz
Summary: This study aimed to explore the role of inflammation in patients with anorexia nervosa (AN). The results showed that the inflammatory response was higher in adolescent patients at admission, but differed from adults as the levels of interleukin-1 beta (IL-1 beta) and IL-6 were lower. Additionally, the gut microbiota may play a regulatory role in the inflammatory processes of AN.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Dioneia Araldi, Luiz F. Ferrari, Paul Green, Jon D. Levine
Article
Neurosciences
Luiz F. Ferrari, Dioneia Araldi, Paul Green, Jon D. Levine
Article
Anesthesiology
Pedro Alvarez, Oliver Bogen, Paul G. Green, Jon D. Levine
Article
Clinical Neurology
Pedro Alvarez, Paul G. Green, Jon D. Levine
Article
Neurosciences
Luiz F. Ferrari, Dioneia Araldi, Oliver Bogen, Paul G. Green, Jon D. Levine
Article
Neurosciences
Dioneia Araldi, Oliver Bogen, Paul G. Green, Jon D. Levine
JOURNAL OF NEUROSCIENCE
(2019)
Article
Anesthesiology
Sarah D. Linnstaedt, Cathleen A. Rueckeis, Kyle D. Riker, Yue Pan, Alan Wu, Shan Yu, Britannia Wanstrath, Michael Gonzalez, Evan Harmon, Paul Green, Chieh Chen, Tony King, Christopher Lewandowski, Phyllis L. Hendry, Claire Pearson, Michael C. Kurz, Elizabeth Datner, Marc-Anthony Velilla, Robert Domeier, Israel Liberzon, Jeffrey S. Mogil, Jon Levine, Samuel A. McLean
Article
Anesthesiology
Luiz F. Ferrari, Dioneia Araldi, Paul G. Green, Jon D. Levine
Article
Neurosciences
Ivan J. M. Bonet, Dioneia Araldi, Eugen Khomula, Oliver Bogen, Paul G. Green, Jon D. Levine
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Teruaki Masutani, Shuhei Yamada, Akira Hara, Tatsuji Takahashi, Paul G. Green, Masayuki Niwa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Larissa Staurengo-Ferrari, Ivan J. M. Bonet, Dioneia Araldi, Paul G. Green, Jon D. Levine
Summary: Duloxetine is an effective treatment for chemotherapy-induced peripheral neuropathy (CIPN), but our ability to predict patient response is still limited. A study found that neuroendocrine stress axes play a role in the analgesic effect of duloxetine in CIPN. Duloxetine can prevent and reverse mechanical hyperalgesia associated with CIPN, and its effectiveness differs between genders and in response to stress.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Paul G. Green, Pedro Alvarez, Jon D. Levine
Summary: Alcohol use disorder is a major health problem causing millions of deaths worldwide. This study found that feeding rats with probiotics can alleviate alcohol-induced muscle mechanical hyperalgesia. Administration of probiotics to individuals with alcohol use disorder may reduce pain associated with alcohol consumption and withdrawal, providing a potential therapeutic intervention.
Article
Anesthesiology
Ivan J. M. Bonet, Larissa Staurengo-Ferrari, Dioneia Araldi, Paul G. Green, Jon D. Levine
Summary: HMWH can alleviate chemotherapy-induced peripheral neuropathy caused by oxaliplatin and paclitaxel by acting on CD44 receptor and signaling through RhoA, phospholipase C, and PI3K gamma.
Article
Anesthesiology
Larissa Staurengo-Ferrari, Dioneia Araldi, Paul G. Green, Jon D. Levine
Summary: Stress can worsen cancer chemotherapy-induced peripheral neuropathy (CIPN) and play a role in the pain induced by oxaliplatin. Male rats with oxaliplatin-induced hyperalgesic priming showed prolonged hyperalgesia, which was attenuated in adrenalectomized rats. Neonatal handling prevented oxaliplatin-induced hyperalgesic priming. The hypothalamic-pituitary-adrenal and sympathoadrenal neuroendocrine stress axes were involved in oxaliplatin CIPN in rats.
Article
Neurosciences
Paul G. Green, Pedro Alvarez, Jon D. Levine
Summary: The study showed that adult rats who experienced early-life stress exhibited persistent muscle mechanical hyperalgesia, which could be significantly reduced by probiotics or non-absorbable antibiotics. Therefore, modulation of the gut microbiome using probiotics or antibiotics may provide a novel therapeutic approach for treating chronic musculoskeletal pain.
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)