Review
Medicine, General & Internal
Yue Zhou, Liang-da Li
Summary: This systematic review evaluates the effect of exercise training in the treatment of patients with mild cognitive impairment (MCI). The results show that physical exercise can improve cognitive and physical function in patients with MCI. However, more high-quality research is needed to further validate these findings.
Review
Geriatrics & Gerontology
MoonKi Choi, Hayeon Kim, Juyeon Bae
Summary: This study found that nutritional interventions combined with resistance training did not have additional effects on body composition, muscle strength, or physical function, except for creatine which showed synergistic effects on muscle mass.
Article
Geriatrics & Gerontology
Younkyoung Kim, Myeongjeong Chae, Hyunju Yang
Summary: This study developed a cognitive-physical dual-task training program based on familiar cultural backgrounds using fairy tales and found that after the intervention, older adults showed significant improvements in perceived memory, physical self-efficacy, muscle strength, and cognitive function, although changes in EEG indicators were not significant.
Article
Geriatrics & Gerontology
Nadia M. Chu, Karen Bandeen-Roche, Qian-Li Xue, Michelle C. Carlson, A. Richey Sharrett, Alden L. Gross
Summary: Frailty (PFP) and its criteria are associated with cognitive function in older adults, with frailty showing excess effects on cognitive performance beyond criteria contributions. Different criteria have varying effects on cognitive change.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
M. Cristina Polidori, Wilhelm Stahl, Helen R. Griffiths
Summary: Nutritional cognitive neuroscience is a newly established field that focuses on the impact of nutrition on cognition and brain health, especially in individuals with cognitive frailty. Carotenoids have been shown to play a crucial role in improving cognitive function in this population. Further research is needed to integrate carotenoid interventions into multidomain, personalized lifestyle strategies.
Article
Nutrition & Dietetics
Adriana Caldo-Silva, Guilherme Eustaquio Furtado, Matheus Uba Chupel, Andre L. L. Bachi, Marcelo P. de Barros, Rafael Neves, Emanuele Marzetti, Alain Massart, Ana Maria Teixeira
Summary: The study showed that a 40-week multifactorial intervention had slight effects on the inflammatory and physical function of frail older participants, with the ME plus BCAAs group showing improvements in cognitive profile, muscle strength, and reduction in inflammation levels.
Article
Psychology, Multidisciplinary
Reinaldo Maeneja, Claudia R. Silva, Ines S. Ferreira, Ana Maria Abreu
Summary: This study confirms that aerobic physical exercise has greater benefits for cognitive recovery in stroke patients.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Roberta Zupo, Fabio Castellana, Vito Guerra, Rossella Donghia, Ilaria Bortone, Chiara Griseta, Luisa Lampignano, Vittorio Dibello, Madia Lozupone, Helio Jose Coelho-Junior, Vincenzo Solfrizzi, Gianluigi Giannelli, Giovanni De Pergola, Heiner Boeing, Rodolfo Sardone, Francesco Panza
Summary: Preventive nutritional management of frailty may reduce adverse health-related outcomes in older adults. A novel measure combining physical frailty with nutritional imbalance, known as nutritional frailty, was found to be a better predictor of all-cause mortality compared to physical frailty alone or cognitive frailty.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Public, Environmental & Occupational Health
Spela Bogataj, Katja Kurnik Mesaric, Maja Pajek, Tanja Petrusic, Jernej Pajek
Summary: The present review suggests that physical exercise might improve or at least not worsen cognitive performance in HD patients, whereas the effect of cognitive training has not yet been adequately studied. More sensitive and specific cognitive tests are needed to adequately measure the effects of interventions in the HD population.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Cell Biology
Hanna Malmberg Gavelin, Christopher Dong, Ruth Minkov, Alex Bahar-Fuchs, Kathryn A. Ellis, Nicola T. Lautenschlager, Maddison L. Mellow, Alexandra T. Wade, Ashleigh E. Smith, Carsten Finke, Stephan Krohn, Amit Lampit
Summary: Combining physical exercise with cognitive training is a popular intervention in dementia prevention, with simultaneous and sequential combined interventions showing more significant effects compared to single-domain training. This approach is effective in promoting cognitive and physical health in older adults, surpassing physical exercise alone.
AGEING RESEARCH REVIEWS
(2021)
Review
Geriatrics & Gerontology
Paulo Giusti Rossi, Bianca Ferdin Carnavale, Ana Claudia Silva Farche, Juliana Hotta Ansai, Larissa Pires de Andrade, Anielle Cristhine de Medeiros Takahashi
Summary: This study analyzed the effects of physical exercise on the cognition of community-dwelling older adults with frailty syndrome through six randomized clinical trials. The data from the meta analysis showed that physical exercise can improve both global cognition and mental flexibility in this population. The interventions with physical exercise were found to promote benefits in cognitive function for older adults with frailty syndrome.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Geriatrics & Gerontology
Xingqi Cao, Chen Chen, Jingyun Zhang, Qian-Li Xue, Emiel O. Hoogendijk, Xiaoting Liu, Shujuan Li, Xiaofeng Wang, Yimin Zhu, Zuyun Liu
Summary: This study determined the proportions of vulnerable individuals identified by three aging metrics that incorporate cognitive and physical function, and investigated their associations with mortality risk. The results showed that all three metrics were able to predict mortality risk, with CI-PF and FI performing better than age and sex alone. The findings highlight the importance of incorporating cognitive and physical function in risk stratification.
Review
Physiology
Azianah Ibrahim, Arimi Fitri Mat Ludin, Devinder Kaur Ajit Singh, Nor Fadilah Rajab, Suzana Shahar
Summary: The aim of this study was to review the changes in cardiovascular-related blood parameters following exercise intervention among older adults with cognitive frailty. The results showed that multicomponent exercise, especially with aerobic exercise, can reduce inflammatory markers and increase anti-inflammatory markers. Both multicomponent exercise and aerobic exercise improved glucose homeostasis and lipid metabolism. Therefore, multicomponent exercise plays an important role in improving cardiovascular health in older adults with cognitive frailty.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Ragnhild Munthe-Kaas, Stina Aam, Ingvild Saltvedt, Torgeir Bruun Wyller, Sarah T. Pendlebury, Stian Lydersen, Guri Hagberg, Till Schellhorn, Siri Rostoft, Hege Ihle-Hansen
Summary: This study compared the predictive value of pre-stroke Frailty Index (FI) and modified Rankin Scale (mRS) for post-stroke neurocognitive disorder (NCD). The results showed that FI was a stronger predictor of post-stroke NCD than mRS and could be included in the prediction models for cognitive prognosis post-stroke.
Article
Geriatrics & Gerontology
Kai Cui, Weihan Meng, Zhiqiang Li, Xinning Zeng, Xiaozhe Li, Xiaoyan Ge
Summary: Little is known about the association between cognitive function and frailty in Chinese older adults. This study investigated the temporal sequences between cognitive function and frailty using longitudinal data. The results showed a reciprocal association between cognition and frailty.
Article
Geriatrics & Gerontology
Helge Molde, Inger Hilde Nordhus, Torbjorn Torsheim, Knut Engedal, Anette Bakkane Bendixen, Gerard J. Byrne, Maria Marquez-Gonzalez, Andres Losada, Lei Feng, Elisabeth Kuan Tai Ow, Kullaya Pisitsungkagarn, Nattasuda Taephant, Somboon Jarukasemthawee, Alexandra Champagne, Philippe Landreville, Patrick Gosselin, Oscar Ribeiro, Gretchen J. Diefenbach, Karen Blank, Sherry A. Beaudreau, Jerson Laks, Narahyana Bom de Araujo, Rochele Paz Fonseca, Renata Kochhann, Analuiza Camozzato, Rob H. S. van den Brink, Mario Fluiter, Paul Naarding, Loeki P. R. M. Pelzers, Astrid Lugtenburg, Richard C. Oude Voshaar, Nancy A. Pachana
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2020)
Article
Clinical Neurology
Junhong Yu, Simon L. Collinson, Tau Ming Liew, Tze-Pin Ng, Rathi Mahendran, Ee-Heok Kua, Lei Feng
APPLIED NEUROPSYCHOLOGY-ADULT
(2020)
Article
Nutrition & Dietetics
Yi-Wen Jiang, Li-Ting Sheng, Xiong-Fei Pan, Lei Feng, Jian-Min Yuan, An Pan, Woon-Puay Koh
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Mohammad Talaei, Lei Feng, Jian-Min Yuan, An Pan, Woon-Puay Koh
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Obstetrics & Gynecology
Xingyue Song, Jing Wu, Yanfeng Zhou, Lei Feng, Jian-Min Yuan, An Pan, Woon Puay Koh
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Review
Clinical Neurology
Jin-Tai Yu, Wei Xu, Chen-Chen Tan, Sandrine Andrieu, John Suckling, Evangelos Evangelou, An Pan, Can Zhang, Jianping Jia, Lei Feng, Ee-Heok Kua, Yan-Jiang Wang, Hui-Fu Wang, Meng-Shan Tan, Jie-Qiong Li, Xiao-He Hou, Yu Wan, Lin Tan, Vincent Mok, Lan Tan, Qiang Dong, Jacques Touchon, Serge Gauthier, Paul S. Aisen, Bruno Vellas
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Neurosciences
Junhong Yu, Iris Rawtaer, Johnson Fam, Lei Feng, Ee-Heok Kua, Rathi Mahendran
Article
Psychiatry
Junhong Yu, Iris Rawtaer, Lei Feng, Johnson Fam, Alan Prem Kumar, Irwin Kee-Mun Cheah, William G. Honer, Wayne Su, Yuan Kun Lee, Ene Choo Tan, Ee Heok Kua, Rathi Mahendran
Summary: Mindfulness-based interventions can enhance cognitive abilities among older adults and delay cognitive decline. Research suggests that mindfulness training leads to cognitive improvements and changes in cortical thickness, offering therapeutic effects for certain cognitive impairments.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Geriatrics & Gerontology
Li-Ting Sheng, Yi-Wen Jiang, Lei Feng, An Pan, Woon-Puay Koh
Summary: The study found a significant association between midlife dietary total antioxidant capacity and cognitive function in later life, with higher antioxidant capacity associated with lower odds of cognitive impairment. Higher intakes of vitamin C, vitamin E, carotenoids, and flavonoids were found to be protective against cognitive impairment.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Junhong Yu, Iris Rawtaer, Lei Feng, Ee-Heok Kua, Rathi Mahendran
Summary: Geriatric depression and anxiety often exhibit as neuropsychiatric symptoms in older adults with mild cognitive impairment. Using connectome-based predictive modeling, researchers found that both types of symptoms are largely underpinned by common patterns of altered functional and structural connectivity, indicating a transdiagnostic neurobiological susceptibility in both disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Ling-Yun Liu, Yanxia Lu, Liang Shen, Chun-Bo Li, Jin-Tai Yu, Chua Ru Yuan, Kaisy Xinhong Ye, Yin Xia Chao, Qing-Feng Shen, Rathi Mahendran, Ee Heok Kua, De-Hua Yu, Lei Feng
Summary: This study investigated the prevalence, risk, and protective factors for MCI among Singaporean Chinese older adults, finding that age, education level, social activity, depression, hypertension, stroke, and other factors are related to MCI. Males are more likely to have amnestic MCI, while females are more likely to have non-amnestic MCI.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Environmental Sciences
Ted Kheng Siang Ng, Lei Feng, Johnson Fam, Iris Rawtaer, Alan Prem Kumar, Grishma Rane, Irwin Kee-Mun Cheah, Ratha Mahendran, Yuan Kun Lee, Ene Choo Tan, Lee Gan Goh, Ee Heok Kua, Rathi Mahendran
Summary: This study aims to investigate the effects of mindfulness awareness practice on cognitive decline and peripheral biomarkers in community-dwelling older adults diagnosed with MCI. Conducted as a single-blinded parallel-group randomized controlled trial, the results have the potential to inform mindfulness intervention as a novel approach to delay dementia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Li-Ting Sheng, Yi-Wen Jiang, Derrick Johnston Alperet, Lei Feng, An Pan, Woon-Puay Koh
Summary: This study aimed to investigate the relationship between fruit and vegetable intake in midlife and cognitive function in late life. The results suggest that increasing the quantity and variety of fruits and vegetables consumed may reduce the risk of cognitive impairment in late life.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Geriatrics & Gerontology
Yi Huang, Narun Pat, Bing Cai Kok, Jingwen Chai, Lei Feng, Rongjun Yu
Summary: This study investigated how older adults experience regret and how they make choices to avoid potential regret in making decisions for themselves and on behalf of others. The findings suggest that although older adults experience blunted regret, their ability to use prospective regret to guide decision-making remains intact.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Review
Geriatrics & Gerontology
Adrian Matysek, Sumudu Perera Kimmantudawage, Lei Feng, Andrea B. Maier
Summary: This study systematically summarizes compounds that inhibit the GSK3 pathway to treat cognitive impairment and dementia. The findings indicate that some natural and synthetic compounds show positive effects on cognition in animal models, but there is a clear lack of translation from animal models to humans.
FRONTIERS IN AGING
(2022)