Article
Cardiac & Cardiovascular Systems
Peter Hanna, Michael J. Dacey, Jaclyn Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P. Biscola, Mohammed A. Swid, Pradeep S. Rajendran, Shumpei Mori, Joseph E. Hadaya, Elizabeth H. Smith, Stanley G. Peirce, Jin Chen, Leif A. Havton, Zixi (Jack) Cheng, Rajanikanth Vadigepalli, James Schwaber, Robert L. Lux, Igor Efimov, John D. Tompkins, Donald B. Hoover, Jeffrey L. Ardell, Kalyanam Shivkumar
Summary: This study provides an in-depth examination of the innervation of the sinoatrial node by the right atrial ganglionated plexus in porcine and human hearts. It demonstrates the significant phenotypic diversity of neurons in the ganglionated plexus and their role in modulating cardiac function. The findings suggest that intrinsic cardiac neurons play a crucial role in controlling specific regions of the heart and could pave the way for targeted therapies in the future.
CIRCULATION RESEARCH
(2021)
Article
Neurosciences
Xiao-Yu Zhang, Xi Wu, Peng Zhang, Ye-Hua Gan
Summary: In this study, the acute and prolonged effects of PGE2 on sodium currents in trigeminal ganglionic neurons were investigated. It was found that prolonged treatment with PGE2 increased the peak sodium current density and tetrodotoxin-sensitive (TTX-S) channel current density. In contrast, acute treatment with PGE2 had different effects on sodium currents, with an increase in peak sodium current density and tetrodotoxin-resistant (TTX-R) channel current density.
Article
Physiology
Piotr Krutki, Wlodzimierz Mrowczynski, Jan Celichowski, Marcin Baczyk
Summary: This study provides new insights into neuronal plasticity following repeated mechanical loading. Through electrophysiological experiments on rat lumbar motoneurons, we demonstrate that low-volume whole body vibration applied systematically for 5 weeks enhances synaptic excitation from primary muscle afferents. The adaptive changes are characterized by higher amplitudes and shorter rise times of monosynaptic EPSPs in the vibrated group compared to the control.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Editorial Material
Clinical Neurology
Regan D. Wright, Allison Sivak, Agessandro Abrahao, Kelvin E. Jones
Summary: The objective of this study was to create an infographic of motor unit number estimation methods over the past 50 years using bibliometric analysis. The primary method was published in 1971, but secondary and tertiary waves of research using alternative methods emerged in the early 2000s and a decade later. A metric of influence was employed to identify if different methods had prominent peaks of usage during the past five decades. Despite the continued influence of the primary method, the MUNIX method introduced in 2004 stood out as the most influential method for estimating the innervation status of skeletal muscles.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
A. Hockley, L. R. Cassinotti, M. Selesko, G. Corfas, S. E. Shore
Summary: Hearing impairment can occur without threshold elevations when high-threshold auditory nerve fibre synapses with cochlear inner hair cells are damaged. This study examined the effects of cochlear synaptopathy on tone-in-noise coding in the cochlear nucleus neurons, which are the central recipients of auditory nerve fibres. The results show that suprathreshold tone-in-noise deficits following cochlear synaptopathy are evident in the cochlear nucleus neurons, indicating a potential target for assessment and treatment of listening-in-noise deficits in humans.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Education, Scientific Disciplines
Jennifer H. Doherty, Jack A. Cerchiara, Mary Pat Wenderoth
Summary: Mastering neurophysiology requires understanding ion movement across cell membranes. The Electrochemical Gradients Assessment Device (EGAD) is used to test students' understanding of key neurophysiology concepts. The study found that students performed better on questions about what, rather than how, and struggled with predicting ion movement using concentration gradient and electric forces. Attractive distractors containing terms related to concentration gradients and equilibrium were common incorrect answers. Analyzing students' answer choices with alluvial diagrams provided insights for neurophysiology instruction.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Education, Scientific Disciplines
Luca Todini, Laura Menchetti
Summary: In this study, an interactive practical classroom was established to engage students in active learning of physiological events. Students actively reproduced these events by positioning themselves and moving around drawings on the ground, resulting in a complete, dynamic, and fluid representation.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Review
Cardiac & Cardiovascular Systems
Corina Schram Serban, Natasja M. S. de Groot
Summary: Obesity is a risk factor for atrial fibrillation, and this systematic review explores the relationship between obesity and atrial electrophysiological characteristics. The findings suggest that obesity increases the risk of atrial electrophysiological abnormalities and susceptibility to atrial fibrillation development.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Clinical Neurology
Luciana Pelosi, Ruth Leadbetter, Eoin Mulroy
Summary: In this study, neuromuscular ultrasound provided significant diagnostic or therapeutic information in over one-third of the investigations for common mononeuropathies. False negative ultrasound studies were uncommon in this setting.
Review
Clinical Neurology
Francesca Puledda, Alessandro Vigano, Gabriele Sebastianelli, Vincenzo Parisi, Fu-Jung Hsiao, Shuu-Jiun Wang, Wei-Ta Chen, Marcello Massimini, Gianluca Coppola
Summary: The cyclical brain disorder of sensory processing accompanying migraine phases lacks an explanatory unified theory. Non-invasive neurophysiological studies on migraine and related conditions have found various changes in brain dynamics during different phases of the migraine cycle. Based on these findings, a unified theory for the pathophysiology of electrophysiological abnormalities underlying migraine recurrence has been proposed.
Review
Medicine, General & Internal
Patricia Mayara Moura da Silva, Ana Beatriz Oliveira Bezerra, Luanna Barbara Araujo Farias, Tatiana Souza Ribeiro, Edgard Morya, Fabricia Azevedo da Costa Cavalcanti
Summary: This protocol aims to systematically summarize the predictive methods used to assess type 2 diabetic gait. The protocol will follow a strict process, including electronic searches, screening of studies, data extraction, and synthesis. The risk of bias and quality of evidence will also be assessed. The findings of this study will be disseminated through peer-reviewed journals, conferences, and other media platforms.
Article
Biochemistry & Molecular Biology
Alastair J. Kirby, Thomas Palmer, Richard J. Mead, Ronaldo M. Ichiyama, Samit Chakrabarty
Summary: This study quantified the survival of alpha-MNs and gamma-MNs in the spinal cord segments of SOD1(G93A) mice and observed a caudal-rostral progression of alpha-MN and corticospinal tract degeneration. This suggests that alpha-MNs and the corticospinal pathway in the lumbar spinal cord are more susceptible to degeneration in SOD1(G93A) mice.
Article
Endocrinology & Metabolism
Nicole Stantonyonge, Saul Martinez-Horta, Frederic Sampedro, Maria Belen Sanchez-Saudinos, Ana Chico
Summary: Impaired awareness of hypoglycaemia is associated with decreased neurophysiological activity in ERPs related to information processing and automatic orientation of attention to novelty and environmental changes. These findings offer a potential framework for better understanding the cognitive origin of impaired awareness of hypoglycaemia in this patient population.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Audiology & Speech-Language Pathology
Grant Rauterkus, Deborah Moncrieff, Gregory Stewart, Erika Skoe
Summary: In concussed athletes, there was a significant group-level decrease in FFR-F0 from baseline (an average decrease of 26%). By contrast, the control group's change from baseline was not statistically significant, and comparisons of pre- and post-season had good repeatability (intraclass correlation coefficient = 0.75).
INTERNATIONAL JOURNAL OF AUDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Auriane C. Ernault, Veronique M. F. Meijborg, Ruben Coronel
Summary: Obesity is a significant risk factor for arrhythmic cardiovascular death. A review investigates the influence of epicardial adipose tissue (EAT) on arrhythmogenesis, highlighting its impact on atrial and ventricular conduction delay, structural cross talk with the heart, and secretion of substances that influence cardiomyocyte electrophysiology. The interaction between EAT and cardiomyocytes facilitates arrhythmias via activation delay, conduction slowing, and increased risk of block.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Neurosciences
Kristine C. Cowley, Brian J. MacNeil, Jeremy W. Chopek, Scott Sutherland, Brian J. Schmidt
EXPERIMENTAL NEUROLOGY
(2015)
Article
Neurosciences
Jeremy W. Chopek, Patricia C. Sheppard, Kalan Gardiner, Phillip F. Gardiner
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Neurosciences
C. W. MacDonell, K. E. Power, J. W. Chopek, K. R. Gardiner, P. F. Gardiner
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Article
Neurosciences
Jeremy W. Chopek, Christopher W. MacDonell, Patricia C. Shepard, Kalan R. Gardiner, Phillip F. Gardiner
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Benjamin P. Whatley, Jeremy W. Chopek, Ron Hill, Robert M. Brownstone
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Review
Neurosciences
Robert M. Brownstone, Jeremy W. Chopek
FRONTIERS IN NEURAL CIRCUITS
(2018)
Article
Neurosciences
Jeremy W. Chopek, Christopher W. MacDonell, Kevin E. Power, Kalan Gardiner, Phillip F. Gardiner
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Critical Care Medicine
Jeremy W. Chopek, Christopher W. MacDonell, Kalan Gardiner, Phillip F. Gardiner
JOURNAL OF NEUROTRAUMA
(2014)
Article
Cell Biology
Jeremy W. Chopek, Phillip F. Gardiner
MECHANISMS OF AGEING AND DEVELOPMENT
(2010)
Article
Cell Biology
Jeremy W. Chopek, Filipe Nascimento, Marco Beato, Robert M. Brownstone, Ying Zhang
Article
Multidisciplinary Sciences
Jeremy W. Chopek, Hans Hultborn, Robert M. Brownstone
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)