Review
Biochemistry & Molecular Biology
Helene Bras, Sylvie Liabeuf
Summary: This review found that after neonatal SCT, there was a normal increase in glycine receptors, but the decrease in GABAA receptors was prevented; while after adult SCT, GABA transmission was altered and KCC2 membrane expression decreased. The study results indicate that in adult SCT rats, glycinergic receptors play a crucial role in controlling spinal MNs inhibition.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Review
Biochemistry & Molecular Biology
Jadwiga N. Bilchak, Guillaume Caron, Marie-Pascale Cote
Summary: Exercise is the superior therapy for most SCI sequalae, influencing peripheral health and CNS disorders by activating relevant neural pathways. Recent research has focused on understanding the molecular underpinnings of exercise-induced effects, particularly the increase in neurotrophins, to enhance intervention strategies and improve quality of life for SCI-affected individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Youngjae Ryu, Toru Ogata, Motoshi Nagao, Yasuhiro Sawada, Ryohei Nishimura, Naoki Fujita
Summary: Early administration of escitalopram after spinal cord injury effectively prevented the onset of spastic behaviors through modulation of the 5-HT system, but did not impact exaggerated spinal reflexes. This suggests a novel application of SSRIs for preventative treatment of spasticity.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Andrea M. Sartori, Anna-Sophie Hofer, Myriam Scheuber, Ruslan Rust, Thomas M. Kessler, Martin E. Schwab
Summary: Neurogenic lower urinary tract dysfunction commonly occurs after spinal cord injury, characterized by detrusor overactivity and detrusor-sphincter-dyssynergia. Changes in spinal cord anatomy, including increased C-fiber afferents and decreased CRF-positive and 5-HT-positive neuronal projections, contribute to the development of lower urinary tract symptoms.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Norbert Grzelak, Piotr Krutki, Marcin Baczyk, Dominik Kaczmarek, Wlodzimierz Mrowczynski
Summary: The purpose of this study was to investigate the effect of altered BDNF concentrations on the electrophysiological properties of spinal MNs. The study found that changes in muscle concentrations of BDNF and GDNF may be critical factors that modify the excitability of spinal MNs after intense physical activity.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
J. Sanchez-Ventura, L. Gimenez-Llort, C. Penas, E. Udina
Summary: PNN is a promising candidate for harnessing neural plasticity, especially in rehabilitation. SCI reduces PNN density in the spinal cord, while activity-based therapies can reverse this decrease and improve functional recovery.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, General & Internal
Seyedezahra Hosseini Ghasabmahaleh, Zahra Rezasoltani, Afsaneh Dadarkhah, Sanaz Hamidipanah, Reza Kazempour Mofrad, Sharif Najafi
Summary: The study suggests that spinal manipulation combined with physiotherapy can improve outcomes for patients with subacute or chronic lumbar radiculopathy over a 3-month period. The manipulation group showed more favorable results in Oswestry scores and straight leg raise test. All ranges of motion significantly increased with manipulation.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Neurosciences
Renaud Jeffrey-Gauthier, Julien Bouyer, Mathieu Piche, Marie-Pascale Cote, Hugues Leblond
Summary: This study found that musculoskeletal injury may hinder locomotor recovery after SCI, with involvement of microglia in this effect, but without modulation of KCC2 expression.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Urszula Slawinska, Henryk Majczynski, Anna Kwasniewska, Krzysztof Miazga, Anna M. Cabaj, Marek Bekisz, Larry M. Jordan, Malgorzata Zawadzka
Summary: The study found that blockade of 5-HT7 receptors in rats leads to an asynchronous stepping pattern between forelimbs and hindlimbs during quadrupedal locomotion, while blockade of 5-HT2A receptors does not. This suggests that 5-HT7 receptors play an important role in coordination of limb movements and may regulate it through interneurons in the spinal cord.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Masahito Takiguchi, Kanae Miyashita, Kohei Yamazaki, Kengo Funakoshi
Summary: ChABC can promote nerve regeneration, plasticity of spinal neurons, and facilitate the regeneration and sprouting of descending axons, leading to the recovery of motor function.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Orthopedics
Masakazu Minetama, Mamoru Kawakami, Masatoshi Teraguchi, Yoshio Enyo, Masafumi Nakagawa, Yoshio Yamamoto, Sachika Matsuo, Tomohiro Nakatani, Nana Sakon, Yukihiro Nakagawa
Summary: This study compared the 1-year follow-up outcomes of patients with lumbar spinal stenosis treated with supervised physical therapy or surgery, finding that, when baseline characteristics were considered, supervised physical therapy yielded similar effects to lumbar surgery.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Akihito Takeda, Mao Fujita, Kengo Funakoshi
Summary: The expression of serotonin and its receptors play an important role in tissue remodeling after spinal cord injury in goldfish. The receptors 5HT2A and 5HT2C are involved in neurogenesis and gliogenesis, contributing to remodeling the fibrous scar. The receptor 5HT1B is involved in remodeling the tubular structures and promoting axonal regeneration.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Review
Clinical Neurology
Federico Temporiti, Silvano Ferrari, Michael Kieser, Roberto Gatti
Summary: This study systematically evaluated the efficacy of various physiotherapy interventions in the treatment of lumbar spinal stenosis (LSS). The findings suggest that weight-supported walking, aquatic exercises, and cycling can improve pain and physical function. Manual therapy plus exercise was found to be more effective than home/group exercises in improving pain, walking tolerance, disability, and quality of life.
EUROPEAN SPINE JOURNAL
(2022)
Article
Neurosciences
Mustafa Gorkem Ozyurt, Julia Ojeda-Alonso, Marco Beato, Filipe Nascimento
Summary: In vitro spinal cord preparations are important for studying the microcircuits involved in movement control. Most research has focused on neonatal mice, while studies on adult mice have been challenging. This study describes two types of coronal spinal cord preparations from mice of different postnatal ages, which allow for the study of spinal motor circuits in young mice that have reached the adult stages of locomotor development.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lamia Hachoumi, Rebecca Rensner, Claire Richmond, Laurence Picton, HongYan Zhang, Keith T. Sillar
Summary: Dynamic neuronal Na+/K+ pumps regulate neuronal properties and future network output through the generation of usAHP. 5-HT and nitric oxide can influence the function of Na+/K+ pumps and STMM. 5-HT has opposing effects on the locomotor system through the activation of 5-HT7 and 5-HT2a receptors, while nitric oxide exerts a potent inhibitory effect on Na+/K+ pumps and STMM.
Article
Neurosciences
Kristine C. Cowley, Brian J. MacNeil, Jeremy W. Chopek, Scott Sutherland, Brian J. Schmidt
EXPERIMENTAL NEUROLOGY
(2015)
Article
Neurosciences
C. W. MacDonell, K. E. Power, J. W. Chopek, K. R. Gardiner, P. F. Gardiner
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Article
Neurosciences
Christopher W. MacDonell, Jeremy W. Chopek, Kalan R. Gardiner, Phillip F. Gardiner
JOURNAL OF NEUROPHYSIOLOGY
(2017)
Article
Neurosciences
Jeremy W. Chopek, Christopher W. MacDonell, Patricia C. Shepard, Kalan R. Gardiner, Phillip F. Gardiner
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Benjamin P. Whatley, Jeremy W. Chopek, Ron Hill, Robert M. Brownstone
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Review
Neurosciences
Robert M. Brownstone, Jeremy W. Chopek
FRONTIERS IN NEURAL CIRCUITS
(2018)
Article
Neurosciences
Jeremy W. Chopek, Christopher W. MacDonell, Kevin E. Power, Kalan Gardiner, Phillip F. Gardiner
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Critical Care Medicine
Jeremy W. Chopek, Christopher W. MacDonell, Kalan Gardiner, Phillip F. Gardiner
JOURNAL OF NEUROTRAUMA
(2014)
Article
Cell Biology
Jeremy W. Chopek, Phillip F. Gardiner
MECHANISMS OF AGEING AND DEVELOPMENT
(2010)
Article
Cell Biology
Jeremy W. Chopek, Filipe Nascimento, Marco Beato, Robert M. Brownstone, Ying Zhang
Article
Multidisciplinary Sciences
Jeremy W. Chopek, Hans Hultborn, Robert M. Brownstone
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)