Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma

PGC1α drives a metabolic block on prostate cancer progression

(2016) Martina Wallace et al.   NATURE CELL BIOLOGY

Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids

(2016) Qiwei Yang et al.   Reproductive Sciences

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma

(2016) F Ahmad et al.   Cell Death & Disease

EZH2 promotes metabolic reprogramming in glioblastomas through epigenetic repression of EAF2-HIF1α signaling

(2016) Bo Pang et al.   Oncotarget

Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells

(2016) Yuki Yasumoto et al.   PLoS One

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide

(2015) J. L. McFaline-Figueroa et al.   CANCER RESEARCH

MacroH2A1 isoforms are associated with epigenetic markers for activation of lipogenic genes in fat-induced steatosis

(2015) Christine Podrini et al.   FASEB JOURNAL

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

(2015) Yinghui Li et al.   NATURE CELL BIOLOGY

PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases

(2015) Shiqin Xiong et al.   Cell Reports

Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis

(2014) Susanne Grube et al.   JOURNAL OF NEURO-ONCOLOGY

Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas

(2014) Tomihiro Wakamiya et al.   NEUROPATHOLOGY

Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells

(2013) Eunhee Kim et al.   CANCER CELL

Chromatin Regulator PRC2 Is a Key Regulator of Epigenetic Plasticity in Glioblastoma

(2013) A. Natsume et al.   CANCER RESEARCH

Polycomb repressive complex 2 contributes to DNA double-strand break repair

(2013) Stuart Campbell et al.   CELL CYCLE

Short Telomeres in ESCs Lead to Unstable Differentiation

(2013) Fabio Pucci et al.   Cell Stem Cell

Tumor Necrosis Factor Alpha-Induced Hypoxia-Inducible Factor 1 - -Catenin Axis Regulates Major Histocompatibility Complex Class I Gene Activation through Chromatin Remodeling

(2013) S. Ghosh et al.   MOLECULAR AND CELLULAR BIOLOGY

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

(2013) Jiali Li et al.   NATURE NEUROSCIENCE

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

(2013) Annika Mehlem et al.   Nature Protocols

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

(2012) D Dixit et al.   Cell Death & Disease

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

Involvement of TNFα-induced TLR4–NF-κB and TLR4–HIF-1α feed-forward loops in the regulation of inflammatory responses in glioma

(2011) Richa Tewari et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells

(2011) W.-C. Huang et al.   MOLECULAR CANCER RESEARCH

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo

(2010) Sha Hu et al.   CANCER BIOLOGY & THERAPY

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

(2010) Claudia Cosentino et al.   EMBO JOURNAL

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Promotes Skeletal Muscle Lipid Refuelingin Vivoby Activatingde NovoLipogenesis and the Pentose Phosphate Pathway

(2010) Serge Summermatter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells

(2010) F. Orzan et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

An Optimized Pentaplex PCR for Detecting DNA Mismatch Repair-Deficient Colorectal Cancers

(2010) Ajay Goel et al.   PLoS One

Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation

(2009) Deobrat Dixit et al.   FREE RADICAL BIOLOGY AND MEDICINE

MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres

(2008) Paula Martinez et al.   AGING CELL

Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase

(2008) Rijin Xiao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of MutS homolog 2 (MSH2) in intestinal myofibroblast proliferation during Crohn's disease stricture formation

(2008) Martin Floer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Saturated Fatty Acids Modulate Cell Response to DNA Damage: Implication for Their Role in Tumorigenesis

(2008) Li Zeng et al.   PLoS One