Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus

Autophagy proteins are modulated in the liver and hypothalamus of the offspring of mice with diet-induced obesity

(2016) Andressa Reginato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Short term exendin-4 treatment reduces markers of metabolic disorders in female offspring of obese rat dams

(2015) Yik Lung Chan et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

(2015) Daniela Senft et al.   TRENDS IN BIOCHEMICAL SCIENCES

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

(2015) Antonio Zorzano et al.   Frontiers in Aging Neuroscience

Hypothalamic endoplasmic reticulum stress and insulin resistance in offspring of mice dams fed high-fat diet during pregnancy and lactation

(2014) Arine M. Melo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes

(2014) Yu-Mi Lim et al.   Nature Communications

4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor

(2013) Seisuke Mimori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents

(2013) Hui Chen et al.   DIABETOLOGIA

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

(2013) Isin Çakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The risk of maternal obesity to the long-term health of the offspring

(2012) James R. O'Reilly et al.   CLINICAL ENDOCRINOLOGY

Parkin in the regulation of fat uptake and mitochondrial biology

(2012) Kye-Young Kim et al.   CURRENT OPINION IN LIPIDOLOGY

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

ERdj4 Protein Is a Soluble Endoplasmic Reticulum (ER) DnaJ Family Protein That Interacts with ER-associated Degradation Machinery

(2012) Chunwei Walter Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unraveling the brain regulation of appetite: lessons from genetics

(2012) Giles S H Yeo et al.   NATURE NEUROSCIENCE

Measuring Adiposity in Patients: The Utility of Body Mass Index (BMI), Percent Body Fat, and Leptin

(2012) Nirav R. Shah et al.   PLoS One

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

(2012) Noritaka Kawasaki et al.   Scientific Reports

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Absence of Melatonin Induces Night-Time Hepatic Insulin Resistance and Increased Gluconeogenesis Due to Stimulation of Nocturnal Unfolded Protein Response

(2011) Tatiane C. Nogueira et al.   ENDOCRINOLOGY

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe

(2010) Mei J. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring

(2009) Kathleen C. Page et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance

(2009) P. Nivoit et al.   DIABETOLOGIA

Hypothalamic Neuroendocrine Circuitry is Programmed by Maternal Obesity: Interaction with Postnatal Nutritional Environment

(2009) Hui Chen et al.   PLoS One

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Maternal and Postnatal Overnutrition Differentially Impact Appetite Regulators and Fuel Metabolism

(2008) Hui Chen et al.   ENDOCRINOLOGY

Maternal High-Fat Diet and Fetal Programming: Increased Proliferation of Hypothalamic Peptide-Producing Neurons That Increase Risk for Overeating and Obesity

(2008) G.-Q. Chang et al.   JOURNAL OF NEUROSCIENCE

Offspring from mothers fed a ‘junk food’ diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females

(2008) S. A. Bayol et al.   JOURNAL OF PHYSIOLOGY-LONDON

Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance

(2007) Anne-Maj Samuelsson et al.   HYPERTENSION