Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Roberta Dourado Cavalcante da Cunha de Sa, Jussara de Jesus Simao, Viviane Simoes da Silva, Talita Mendes de Farias, Maysa Mariana Cruz, Vitor Jaco Antraco, Lucia Armelin-Correa, Maria Isabel Alonso-Vale
Summary: This study found that different ratios of EPA and DHA have different impacts on adipose tissue metabolism, with fish oil rich in EPA instead of DHA effectively reversing changes induced by obesity.
Article
Nutrition & Dietetics
Marie C. Conway, Emeir M. McSorley, Maria S. Mulhern, Toni Spence, Edwin van Wijngaarden, Gene E. Watson, Karin Wahlberg, Daniela Pineda, Karin Broberg, Barry W. Hyland, Diego F. Cobice, J. J. Strain, Alison J. Yeates
Summary: The study found that consuming two portions of fish per week significantly increased concentrations of EPA, DHA, and total n-3 PUFA in women of childbearing age, with a lower n-6:n-3 ratio compared to those consuming no fish or one portion per week. However, fish consumption did not have a significant effect on biomarkers of oxidative stress, inflammation, and lipid profile in the current study.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Tomoaki Okada, Toru Miyoshi, Masayuki Doi, Kosuke Seiyama, Wataru Takagi, Masahiro Sogo, Kazumasa Nosaka, Masahiko Takahashi, Keisuke Okawa, Hiroshi Ito
Summary: This study aimed to retrospectively investigate the 10-year trend of changes in polyunsaturated fatty acids in patients with acute coronary syndrome, revealing a secular decreasing trend in EPA and DHA levels, but not in AA and DGLA levels. The decreasing trend in EPA and DHA levels was not age-dependent and remained significant only in men, highlighting the need for further research on the effects of n-3 PUFAs on secondary prevention of ACS.
Article
Biology
Wang Ma, Mengzhen Liu, Zixu Zhang, Yingshuang Xu, Pengwei Huang, Dongsheng Guo, Xiaoman Sun, He Huang
Summary: In this study, a MetE-like complex was described for the first time, which can increase the content of EPA in Schizochytrium sp. and thus enhance its production. Lipidomics analysis revealed that EPA is more inclined to be stored as triglyceride. These findings suggest that Schizochytrium sp. has great potential for co-production of EPA and DHA.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biology
Yohei Ishibashi, Hatsumi Goda, Rie Hamaguchi, Keishi Sakaguchi, Takayoshi Sekiguchi, Yuko Ishiwata, Yuji Okita, Seiya Mochinaga, Shingo Ikeuchi, Takahiro Mizobuchi, Yoshitake Takao, Kazuki Mori, Kosuke Tashiro, Nozomu Okino, Daiske Honda, Masahiro Hayashi, Makoto Ito
Summary: This study demonstrated that Parietichytrium sp. synthesizes DHA only through the elongase/desaturase pathway, and engineering this thraustochytrid allowed the production of EPA and n-3DPA. This system may provide a suitable solution for the large scale production of omega-3 fatty acids.
COMMUNICATIONS BIOLOGY
(2021)
Review
Medicine, General & Internal
Ashish Gupta, Mohammad Alkhalil
Summary: Omega-3 polyunsaturated fatty acids (PUFAs) have been established as a therapeutic option for patients with high triglyceride levels. They have effects on lipoprotein particles and can be incorporated within the cellular membrane, leading to plaque stability and anti-inflammatory effects. However, recent clinical trials have shown inconsistent results regarding the cardioprotective effects of omega-3 fatty acids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Maike Wolters, Annkathrin von der Haar, Ann-Kristin Baalmann, Maike Wellbrock, Thomas L. Heise, Stefan Rach
Summary: The review found that supplementation of n-3 PUFAs has a modest beneficial effect on depressive symptoms, particularly in individuals with longer treatment duration and those without depression or with mild to moderate depression. However, there are differences in effects based on different EPA dosages, and the overall quality of evidence remains insufficient.
Article
Nutrition & Dietetics
Toshiaki Sueyasu, Keisuke Yasumoto, Hisanori Tokuda, Yoshihisa Kaneda, Hidenori Obata, Tomohiro Rogi, Takayuki Izumo, Sumio Kondo, Jiro Saito, Takashi Tsukiura, Masaaki Nakai
Summary: Long-chain polyunsaturated fatty acids (LCPUFAs) and lutein (L) and zeaxanthin (Z) can improve brain function. This study aimed to determine if LCPUFAs + LZ-supplemented food could improve memory function. The results showed that LCPUFAs + LZ supplementation improved memory function in healthy older individuals with cognitive decline.
Review
Nutrition & Dietetics
Amy H. R. Wood, Helen F. Chappell, Michael A. Zulyniak
Summary: This review summarizes evidence from observational studies and clinical trials on the protective effect of LC omega-3 PUFAs against cognitive impairment and reduced risk of Alzheimer's disease. Findings suggest that individuals consuming higher amounts of LC omega-3 PUFAs are less likely to develop cognitive impairment and may benefit from a preventative strategy against Alzheimer's disease when consumed prior to or in the early stages of cognitive decline.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Sarah Fathima, Ekatherine Prokopiou, Tassos Georgiou
Summary: Diabetic retinopathy is a common complication of type 2 Diabetes Mellitus that can lead to vision loss. The use of anti-oxidants for treatment has not been strongly supported by data. Omega-3 fatty acids have shown promising effects on cardiovascular health and their anti-oxidative and anti-inflammatory properties make them potential therapeutic agents for diabetic retinopathy. However, more clinical trials are needed to fully understand their benefits.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Nutrition & Dietetics
Jing Chen, Johan Garssen, Frank Redegeld
Summary: The study showed cell type-dependent anticancer potential of DHA and EPA. Both compounds induced apoptosis in MM cells via multiple pathways and enhanced bortezomib chemosensitivity by activating NF-kappa B signaling pathway. Timing of concurrent treatment with bortezomib and DHA or EPA is crucial for optimal therapeutic outcomes.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Michael J. Patan, David O. Kennedy, Cathrine Husberg, Svein Olaf Hustvedt, Philip C. Calder, Julie Khan, Joanne Forster, Philippa A. Jackson
Summary: This study found that oil rich in EPA can improve cognitive performance and memory accuracy, and outperformed oil enriched with DHA. Additionally, n-3 PUFAs may be associated with increased cognitive efficiency.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Nutrition & Dietetics
Hans Demmelmair, Berthold Koletzko
Summary: High obesity rates around the world point to an urgent need for effective obesity prevention measures. Animal studies suggest that the effects of essential polyunsaturated fatty acids on adipogenesis may be mediated through various mechanisms. Divergent findings from human clinical trials and observational studies suggest that recommendations for humans regarding PUFA and obesity risk are not yet possible.
Article
Multidisciplinary Sciences
Yuri Kato, Kengo Ohsugi, Yuto Fukuno, Ken Iwatsuki, Yuika Harada, Takaaki Miyaji
Summary: This study found that EPA and its metabolites can alleviate neuropathic and inflammatory pain by inhibiting VNUT, as well as improve insulin resistance. This suggests that EPA may serve as a unique nutrient-based treatment and prevention strategy for neurological, immunological, and metabolic diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Xianshu Ju, Jianchen Cui, Yulim Lee, Sangil Park, Boohwi Hong, Sungho Yoo, Yoon Hee Kim, Youngkwon Ko, Chaeseong Lim, Sun Yeul Lee, Gi Ryang Kweon, Jun Young Heo, Woosuk Chung
Summary: This study reveals that short-interval anesthetic exposures may induce significant behavioral and neurophysiological changes, especially in female mice, while long-interval exposures show no lasting consequences. Increasing the interval between multiple exposures may reduce neurotoxic effects.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Anesthesiology
Yulim Lee, Ann Misun Youn, Xianshu Ju, Jianchen Cui, Boohwi Hong, Sangwon Yun, Youngkwon Ko, Yoon Hee Kim, Jun Young Heo, Woosuk Chung
Summary: Multiple ketamine injections induce interval-dependent, long-lasting synaptic changes and behavioral impairments. Future studies should carefully consider the dosing interval as a significant factor when studying the neurotoxic effects of multiple anesthetic exposures.
JOURNAL OF ANESTHESIA
(2021)
Article
Medicine, General & Internal
Yeojung Kim, Sangwon Yun, Keun-A Shin, Woosuk Chung, Youngkwon Ko, Yoon-Hee Kim, Chaeseong Lim
Summary: Sevoflurane exposure at 2% can promote proliferation of LLC cells in vitro, but may not affect cell proliferation in vivo. This suggests that the effects of anesthetics on cancer cells in vitro studies may differ from those in vivo or clinical studies.
MEDICINA-LITHUANIA
(2021)
Article
Biochemistry & Molecular Biology
Do Hyeong Gwon, Song I. Kim, Seoung Hun Lee, Chan Noh, Yeojung Kim, Sangwon Yun, Won Hyung Lee, Jun Young Oh, Dong Woon Kim, Jinpyo Hong, Sun Yeul Lee
Summary: NFAT5 deficiency may alleviate formalin-induced inflammatory pain by upregulating mTOR expression and downregulating its downstream factors in spinal dorsal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jung-Hyo Cho, Jong-Suk Lee, Hyeong-Geug Kim, Hye Won Lee, Zhigang Fang, Hyeok-Hee Kwon, Dong Woon Kim, Chang-Min Lee, Jin-Woo Jeong
Summary: The ethyl acetate fraction of Amomum villosum var. xanthioides (AXEF) showed significant antioxidant and anti-inflammatory effects in a NASH mouse model, alleviating fatty liver induced by ER stress. It reduced lipid droplet accumulations, liver enzymes, hepatic inflammations, and cell death signals.
Article
Multidisciplinary Sciences
Jin-Seok Lee, Sung-Bae Lee, Dong-Woon Kim, Nara Shin, Seon-Ju Jeong, Chae-Ha Yang, Chang-Gue Son
Summary: Social isolation contributes to depressive disorders and alcohol abuse, with depression increasing vulnerability to alcohol consumption. This study using a mouse model found that microglial activation plays a key role in the vicious cycle between depression and alcohol consumption, while dopaminergic reward might also be involved in this pathogenicity.
Article
Nanoscience & Nanotechnology
Hyo Jung Shin, Ka Young Lee, Joon Won Kang, Seung Gyu Choi, Dong Woon Kim, Yoon Young Yi
Summary: Ischemic stroke and neonatal ischemia are major causes of death and disability, but current treatments for perinatal ischemic stroke are lacking. This study investigated the effects of PER-loaded PLGA nanoparticles on microglia in perinatal stroke and found that they reduced inflammation and increased cell polarization. This development of a drug delivery system targeting microglia has the potential to lead to new therapeutic agents for perinatal ischemic stroke.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Neurosciences
Seung Gyu Choi, Juhee Shin, Ka Young Lee, Hyewon Park, Song I. Kim, Yoon Young Yi, Dong Woon Kim, Hee-Jung Song, Hyo Jung Shin
Summary: This study proposes a treatment strategy using nanoparticles to control PINK1, a critical marker in the regulation of mitophagy and mitochondrial dysfunction. The nanoparticles effectively reduce PINK1 expression in microglia, leading to a decrease in ischemic damage and motor dysfunction. This research provides a new nanomedical approach for stroke treatment.
Article
Biochemistry & Molecular Biology
Hyeok Hee Kwon, Seung Yeon Jung, Hyewon Park, Hyo Jung Shin, Dong Woon Kim, Hee-Jung Song, Joon Won Kang
Summary: Oxygenated water has antiepileptic effects on rodent models, increasing the seizure threshold and reducing the frequency and duration of seizures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Donald Ho, Tyler O. Lynd, Claire Jun, Juhee Shin, Reid C. Millican, Benjamin K. Estep, Jun Chen, Xixi Zhang, Brigitta C. Brott, Dong Woon Kim, Jennifer A. Sherwood, Patrick T. J. Hwang
Summary: Vascular insults can lead to vascular diseases such as atherosclerosis through an inflammatory cascade involving endothelial cell, smooth muscle cell, and macrophage activation. This study introduces miR-146a encapsulated liposomes to reduce inflammatory responses in vascular cells and macrophages. The results showed that miR-146a encapsulated liposomes effectively reduced vascular inflammation by inhibiting ICAM-1 expression, decreasing monocyte adhesion, and reducing proinflammatory cytokine production and foam cell formation.
Article
Biochemistry & Molecular Biology
Shuyu Piao, Ikjun Lee, Seonhee Kim, Hyewon Park, Harsha Nagar, Su-Jeong Choi, Giang-Huong Vu, Minsoo Kim, Eun-Ok Lee, Byeong-Hwa Jeon, Dong Woon Kim, Youngduk Seo, Cuk-Seong Kim
Summary: This study investigates the role of CRIF1 deficiency in modulating mitochondrial oxidative phosphorylation (OXPHOS) system dysfunction and its antitumor effects in MCF-7 breast cancer cells. CRIF1 silencing decreases the assembly of mitochondrial OXPHOS complexes, leading to mitochondrial dysfunction and elevated reactive oxygen species (ROS) levels. Inhibition of CRIF1 suppresses cell proliferation and inhibits cell migration in MCF-7 cells, and intratumoral injection of CRIF1 siRNA nanoparticles inhibits tumor growth in MCF-7 xenograft mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Yumin Jo, Seyeon Park, Chahyun Oh, Yujin Pak, Kuhee Jeong, Sangwon Yun, Chan Noh, Woosuk Chung, Yoon-Hee Kim, Young Kwon Ko, Boohwi Hong
Summary: A network meta-analysis was conducted to determine the relative efficacy of regional analgesic interventions for video-assisted thoracic surgery (VATS). The results showed that thoracic paravertebral block (TPVB) had the greatest effect on opioid consumption, while erector spinae plane block (ESPB) had comparable analgesic efficacy. Further studies are needed to determine the optimal regional analgesia technique for improving postoperative pain control after VATS.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2022)
Article
Materials Science, Biomaterials
Hyewon Park, Ha-Reum Lee, Hyo Jung Shin, Ji Ah Park, Yongbum Joo, Sun Moon Kim, Jaewon Beom, Seong Wook Kang, Dong Woon Kim, Jinhyun Kim
Summary: In this study, p16INK4a nanoparticles were used to treat OA patients, successfully reducing pain-related behavior and minimizing cartilage damage.
BIOMATERIALS SCIENCE
(2022)
Article
Orthopedics
Woo-Yong Lee, Young-Mo Kim, Deuk-Soo Hwang, Hyun-Dae Shin, Yong-Bum Joo, Soo Min Cha, Kyung-Hee Kim, Yoo-Sun Jeon, Sun-Yeul Lee
Summary: The study aimed to compare the histologic outcomes of RC repair with and without DBM augmentation in a rabbit model. Results showed good TB interface healing with DBM augmentation, but further evaluation in vivo setting is needed for clinical recommendations due to the small sample size.
CLINICS IN ORTHOPEDIC SURGERY
(2021)
Article
Materials Science, Biomaterials
Chung Min Shin, Soojeong Cho, Dong Ho Kim, Yooseok Ha, Hyo Jung Shin, Nara Shin, Dong Woon Kim, Chul Hee Choi, Woo Kyung Cho, Sang-Ha Oh
Summary: Research has shown that silicone implants coated with ZW-DOPA can effectively prevent biofilm formation, inhibit capsule formation, and prevent fibroblasts from differentiating into myofibroblasts.
BIOMATERIALS SCIENCE
(2021)
