FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation

Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro

(2016) Tamás Mészáros et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions

(2016) Jonathan P. Hannan et al.   PLoS One

The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

(2015) Arnab Bhattacharjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation

(2015) Ádám I. Csincsi et al.   JOURNAL OF IMMUNOLOGY

Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces

(2015) Q. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Factor H-related proteins determine complement-activating surfaces

(2015) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY

Comparison of Mouse and Human Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related Macular Degeneration

(2015) Anna Bennis et al.   PLoS One

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

(2014) L. Deban et al.   JOURNAL OF IMMUNOLOGY

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

(2014) Simon J. Clark et al.   JOURNAL OF IMMUNOLOGY

A Novel Atypical Hemolytic Uremic Syndrome-Associated Hybrid CFHR1/CFH Gene Encoding a Fusion Protein That Antagonizes Factor H-Dependent Complement Regulation

(2014) E. Valoti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Structural basis for sialic acid–mediated self-recognition by complement factor H

(2014) Bärbel S Blaum et al.   Nature Chemical Biology

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

(2013) Agustín Tortajada et al.   JOURNAL OF CLINICAL INVESTIGATION

Complement factor H related proteins (CFHRs)

(2013) Christine Skerka et al.   MOLECULAR IMMUNOLOGY

A novel hybrid CFHR1/CFH gene causes atypical hemolytic uremic syndrome

(2013) Stephen J. Eyler et al.   PEDIATRIC NEPHROLOGY

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion

(2012) Andrew P. Herbert et al.   BIOCHEMISTRY

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

(2012) Mario Hebecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Hemolytic Uremic Syndrome-Associated Variants and Autoantibodies Impair Binding of Factor H and Factor H-Related Protein 1 to Pentraxin 3

(2012) A. Kopp et al.   JOURNAL OF IMMUNOLOGY

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

(2012) Mónica Marcela Castiblanco-Valencia et al.   JOURNAL OF INFECTIOUS DISEASES

Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome

(2011) Stefanie Strobel et al.   KIDNEY INTERNATIONAL

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Acidic pH-dependent Ligands of Pentameric C-reactive Protein

(2010) David J. Hammond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome

(2010) Svetlana Hakobyan et al.   KIDNEY INTERNATIONAL

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome

(2009) C. Abarrategui-Garrido et al.   BLOOD

Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H

(2009) M Mihlan et al.   CELL DEATH AND DIFFERENTIATION

Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations

(2009) Azubuike I. Okemefuna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome

(2009) M-A Dragon-Durey et al.   JOURNAL OF MEDICAL GENETICS

Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4

(2009) Mario Hebecker et al.   MOLECULAR IMMUNOLOGY

Complement Factor H Binds to Denatured Rather than to Native Pentameric C-reactive Protein

(2008) Svetlana Hakobyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells

(2008) Michael Mihlan et al.   MOLECULAR IMMUNOLOGY