The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

Structural basis for sialic acid–mediated self-recognition by complement factor H

(2014) Bärbel S Blaum et al.   Nature Chemical Biology

Structural Basis for Complement Evasion by Lyme Disease PathogenBorrelia burgdorferi

(2013) Arnab Bhattacharjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children

(2013) Aditi Sinha et al.   KIDNEY INTERNATIONAL

A prevalent CFHR1/FH reverse hybrid gene in aHUS patients induces deregulation of the alternative pathway

(2013) L. Roumenina et al.   MOLECULAR IMMUNOLOGY

A novel hybrid CFHR1/CFH gene causes atypical hemolytic uremic syndrome

(2013) Stephen J. Eyler et al.   PEDIATRIC NEPHROLOGY

Determining the Population Frequency of the CFHR3/CFHR1 Deletion at 1q32

(2013) Lucy V. Holmes et al.   PLoS One

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbes Bind Complement Inhibitor Factor H via a Common Site

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Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion

(2012) Andrew P. Herbert et al.   BIOCHEMISTRY

Complement Factor H-Related Protein 1 Deficiency and Factor H Antibodies in Pediatric Patients with Atypical Hemolytic Uremic Syndrome

(2012) J. Hofer et al.   Clinical Journal of the American Society of Nephrology

Factor H-related Protein 4 Activates Complement by Serving as a Platform for the Assembly of Alternative Pathway C3 Convertase via Its Interaction with C3b Protein

(2012) Mario Hebecker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overall Neutralization of Complement Factor H by Autoantibodies in the Acute Phase of the Autoimmune Form of Atypical Hemolytic Uremic Syndrome

(2012) C. Blanc et al.   JOURNAL OF IMMUNOLOGY

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP

(2012) Mónica Marcela Castiblanco-Valencia et al.   JOURNAL OF INFECTIOUS DISEASES

Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome

(2011) Stefanie Strobel et al.   KIDNEY INTERNATIONAL

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Advances in understanding the aetiology of atypical Haemolytic Uraemic Syndrome

(2010) Pilar Sánchez-Corral et al.   BRITISH JOURNAL OF HAEMATOLOGY

Clinical Features of Anti-Factor H Autoantibody-Associated Hemolytic Uremic Syndrome

(2010) M.-A. Dragon-Durey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d

(2010) Arnab Bhattacharjee et al.   MOLECULAR IMMUNOLOGY

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

(2009) I. Moore et al.   BLOOD

Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome

(2009) C. Abarrategui-Garrido et al.   BLOOD

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome

(2009) M-A Dragon-Durey et al.   JOURNAL OF MEDICAL GENETICS

A decade of user operation on the macromolecular crystallography MAD beamline ID14-4 at the ESRF

(2009) Andrew A. McCarthy et al.   JOURNAL OF SYNCHROTRON RADIATION

Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome

(2009) S. Strobel et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Atypical Hemolytic–Uremic Syndrome

(2009) Marina Noris et al.   NEW ENGLAND JOURNAL OF MEDICINE